Results 31 to 40 of about 2,696,015 (152)
The WWOX gene modulates high-density lipoprotein and lipid metabolism. [PDF]
Circ Cardiovasc Genet, 2014 Iatan I +17 more
europepmc +2 more sources
Frontiers in Genetics, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat +5 more
doaj +1 more source
Endogenous Processes Underlying Clock-Like Mutational Signatures. [PDF]
Genes Chromosomes CancerABSTRACT Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging ...
Druck T +4 more
europepmc +2 more sources
WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer [PDF]
, 2010 WWOX is a tumour suppressor gene, as demonstrated by increased neoplasia incidence in Wwox-knock-out animals, and is frequently disrupted in human cancers.
Janczar, Szymon Lech
core +2 more sources
The effects of protocadherin 8 and WWOX in prostate adenocarcinoma
Journal of Men's Health, 2022 Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik +3 more
doaj +1 more source
Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed-Type Thyroid Cancer. [PDF]
Adv Sci (Weinh)The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Zhang X +8 more
europepmc +2 more sources
, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Żaneta Kałuzińska-Kołat (16538187) +11 more
core +1 more source
WWOX: a tumor suppressor gene mutated in multiple cancers [PDF]
, 2001 The present invention provides the isolation and cloning of WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3–24.1, a region frequently affected in several cancers.
Aldaz, C. Marcelo, Bednarek, Andrzej
core +1 more source
Frontiers in Oncology, 2021 IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat +3 more
doaj +1 more source
Frontiers in Neuroscience, 2023 IntroductionGlioblastoma (GBM) is notorious for its clinical and molecular heterogeneity, contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor suppressor genes important in nervous tissue or related pathologies, which was ...
Żaneta Kałuzińska-Kołat +4 more
doaj +1 more source