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WWOX, large common fragile site genes, and cancer [PDF]
Experimental Biology and Medicine, 2015 WWOX is a gene that spans an extremely large chromosomal region. It is derived from within chromosomal band 16q23.2 which is a region with frequent deletions and other alterations in a variety of different cancers. This chromosomal band also contains the FRA16D common fragile site (CFS).
Ge, Gao, David I, Smith
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Frontiers in Genetics, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat +5 more
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The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma [PDF]
, 2014 Background: Prognostic biomarkers are needed for superficial gastroesophageal adenocarcinoma (EAC) to predict clinical outcomes and select therapy. Although recurrent mutations have been characterized in EAC, little is known about their clinical and ...
A Janssen +67 more
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WWOX, the common chromosomal fragile site, FRA16D, cancer gene [PDF]
Cytogenetic and Genome Research, 2003 Gross chromosomal rearrangements and aneuploidy are among the most common somatic genomic abnormalities that occur during cancer initiation and progression, in particular in human solid tumor carcinogenesis. The loss of large chromosomal regions as consequence of gross rearrangements (e.g.
J H, Ludes-Meyers +4 more
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WWOX Modulates ROS-Dependent Senescence in Bladder Cancer
Molecules, 2022 The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu +4 more
doaj +1 more source
Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics [PDF]
PeerJ, 2015 We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca2+ dynamics because Ca2+ is an important intracellular messenger.
Yusuke Tsuruwaka +2 more
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The effects of protocadherin 8 and WWOX in prostate adenocarcinoma
Journal of Men's Health, 2022 Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik +3 more
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A Role for the WWOX Gene in Prostate Cancer [PDF]
Cancer Research, 2006 Abstract Expression of the WWOX gene, encompassing the common chromosome fragile site FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer. We have examined expression and biological functions of WWOX in prostate cancer.
QIN HR +9 more
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Molecular Functions of WWOX Potentially Involved in Cancer Development
Cells, 2021 The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated
Karim Taouis +3 more
doaj +1 more source
WWOX Gene and Gene Product: Tumor Suppression Through Specific Protein Interactions [PDF]
Future Oncology, 2010 The WWOX gene, an archetypal fragile gene, encompasses a chromosomal fragile site at 16q23.2, and encodes the approximately 46-kDa Wwox protein, with WW domains that interact with a growing list of interesting proteins. If the function of a protein is defined by the company it keeps, then Wwox is involved in numerous important signal pathways for bone ...
Zaidoun, Salah +2 more
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