Results 51 to 60 of about 2,696,015 (152)

Role of Tumor Suppressor WWOX in Modulating PD-L1 Expression in Breast Cancers

Experimed
Objective: This study aimed to determine the potential contribution of WWOX to the regulation of PD-L1 expression in breast cancer.Materials and Methods: MDA-MB-231, MCF-7, and MCF10A cell lines were used in this study. The WWOX gene was overexpressed in
Sümbül Gezer, Bahadır Batar
doaj   +1 more source

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, Volume 67, Issue 9, Page 4536-4550, September 2026.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Clinical utility and genetic landscape of exome sequencing in a large pediatric epilepsy cohort: Insights from a Turkish tertiary care center

Epileptic Disorders, Volume 28, Issue 4, Page 1252-1273, August 2026.
Abstract Objective To evaluate the diagnostic utility and genetic spectrum of next‐generation sequencing (NGS) in a large, well‐phenotyped cohort of Turkish pediatric patients with epilepsy of unknown etiology. Methods Between January 2021 and December 2024, 250 children (115 female, 135 male) with unexplained epilepsy underwent either whole‐exome ...
Derya Karaer, Beste Kipçak Yüzbaşı, İpek Şahin, Olcay Güngör, Kadri Karaer   +4 more
wiley   +1 more source

WWOX in brain development and disease: Molecular mechanisms and therapeutic opportunities

Neurobiology of Disease
The WW domain–containing oxidoreductase (WWOX) gene, located at the common fragile site FRA16D, has emerged as a key molecular link between genome instability and nervous system biology.
Mustafa Obeid, Jingkai Wang, Baraa Abudiab, Rania Akkawi, Rami I. Aqeilan   +4 more
doaj   +1 more source

WW domain-containing oxidoreductase-related epileptic encephalopathy in Two Omani Children.

Journal of Biochemical and Clinical Genetics, 2023
Background: Autosomal recessive developmental and epileptic encephalopathy type 28 (DEE28) is a rare genetic disorder that affects children in the early months of life.
Moosa Al-Lawati, Zuha Al-Khaldi, Akbar Mohamed Chettali, Mariya Al-Hinai, Hiba Al-Mazrooey, Ali Al-Ajmi, Salma Al-Harasi, Nadia Al-Hashmi   +7 more
doaj   +1 more source

Targeted deletion of Wwox reveals a tumor suppressor function

, 2011
The WW domain-containing oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in several types of human cancer.
Lian, Jane B., Croce, Carlo M., Trapasso, Francesco, Hagan, John P., Aqeilan, Rami I., Kaou, Mohamed, Zanesi, Nicola, Pekarsky, Yuri, Stein, Gary S., Hussain, Sadiq, Costinean, Stefan, Marshall, Dean   +11 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, Volume 20, Issue 7, Page 1667-1693, July 2026.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Genetic alterations in the non-coding region of the WWOX gene.

, 2015
Genetic alterations in the non-coding region of the WWOX gene.
Pelin Bulut (685421), Erkan Kilic (685423), Seda Ekizoglu (685420), Nur Buyru (685424), Emin Karaman (685422)   +4 more
core   +1 more source

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

BMC Urology, 2021
Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors.
Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +5 more
doaj   +1 more source

Toosendanin Alleviates Cerebral Ischemia/Reperfusion Injury via Inhibiting Neural Ferroptosis Through Lipid Metabolic Reprogramming in MCAO Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Post‐stroke administration of TSN significantly reduced infarct volume, neuroinflammation, and improved functional recovery of MCAO mice. TSN alleviated neural oxidative stress, lipid peroxidation, and ferroptosis in MCAO mice. TSN modulated the infiltration of immune cells in MCAO mice in vivo and T cell differentiation in vitro.
Xinyun Li, Zhiyong Zhao, Jingting Zhao, Xiangming Ye, Zhenfei Xiong, Jiejin Zhao   +5 more
wiley   +1 more source