Results 51 to 60 of about 4,897 (187)
C6orf10 low-frequency and rare variants in italian multiple sclerosis patients [PDF]
, 2019 In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies.
Balestra, Dario +16 more
core +2 more sources
Analysis of WWOX gene expression and protein levels in pterygium
International Ophthalmology, 2020 Pterygium, a degenerative and hyperplastic lesion, has premalignant properties as a tumor analog. WWOX is a tumor suppressor gene and involved in many signal pathways, such as cell proliferation, embryonic development, metabolism and apoptosis. In many cancers, the loss of WWOX or the presence of abnormal transcripts indicates the tumor suppressor ...
Bozkurt, Nihan, Ates, Omer
openaire +3 more sources
Acta Neuropathologica Communications, 2020 Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric ...
Ya-Yun Cheng +14 more
doaj +1 more source
Self-aggregating TIAF1 in lung cancer progression [PDF]
, 2013 Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals.
Chen-Yu Lu +6 more
core +1 more source
The WWOX tumor suppressor gene in endometrial adenocarcinoma
International Journal of Molecular Medicine, 2013 Endometrial cancer is a lethal malignancy, the causes of which remain to be determined. The aim of the present study, carried out on tumor samples from 79 patients, was to evaluate the role of the WWOX tumor suppressor gene in endometrial adenocarcinoma.
Elżbieta, Płuciennik +4 more
openaire +3 more sources
Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview
Cells, 2021 The transcriptional regulator WW domain-containing oxidoreductase (WWOX) is a key player in a number of cellular and biological processes including tumor suppression. Recent evidence has emerged associating WWOX with non-cancer disorders.
Ehud Banne +10 more
doaj +1 more source
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]
, 2015 The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin +58 more
core +2 more sources
Molecular alterations of the WWOX gene in nasopharyngeal carcinoma
Neoplasma, 2014 The WW domain-containing oxidoreductase (WWOX) gene is a candidate tumor suppressor gene. However, its exact mechanism is unclear. This study aimed to investigate the role of the WWOX gene in the development of nasopharyngeal carcinoma (NPC). Tissues were collected from 65 NPC patients.
Z, Yang +6 more
openaire +3 more sources
Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. [PDF]
PLoS ONE, 2012 Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not been possible with full Wwox knockout models. Here we characterize the first conditional models of
Brent W Ferguson +6 more
doaj +1 more source
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. [PDF]
PLoS ONE, 2015 WWOX is a >1 Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of
Louise V O'Keefe +3 more
doaj +1 more source