Results 41 to 50 of about 4,897 (187)
Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]
, 2014 BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo +8 more
core +3 more sources
Histology and histopathology, 2008 Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids.
Yang, Jilong, Zhang, Wei
openaire +3 more sources
BMC Veterinary Research, 2020 Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii +7 more
doaj +1 more source
A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development [PDF]
, 2011 Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling ...
AJ Notini +32 more
core +1 more source
PLoS ONE, 2009 WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.
John H Ludes-Meyers +5 more
doaj +1 more source
The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding [PDF]
, 2013 Background: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors.
Abba, Martín Carlos +6 more
core +3 more sources
Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors [PDF]
, 2014 BACKGROUND: Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies.
Finn Pedersen +3 more
core +6 more sources
Aging, 2021 In this study, we investigated associations between single nucleotide polymorphisms (SNPs) in the tubulin beta class I (TUBB) and WW domain-containing oxidoreductase (WWOX) genes, gene-gene interactions, and gene-environment interactions and dyslipidemia in the Chinese Maonan ethnic group. Four SNPs (rs3132584, rs3130685, rs2222896, and rs2548861) were
Liu, Chun-Xiao +6 more
openaire +2 more sources
Genome-wide association analysis identifies six new loci associated with forced vital capacity [PDF]
, 2014 Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and ...
A Bill Musk +216 more
core +8 more sources
Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development
Frontiers in Neuroscience, 2020 Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans.
Michele Iacomino +31 more
doaj +1 more source