Results 41 to 50 of about 2,696,015 (152)

Location of coding sequence alterations of the WWOX gene.

, 2015
Location of coding sequence alterations of the WWOX gene.
Pelin Bulut (685421), Erkan Kilic (685423), Seda Ekizoglu (685420), Nur Buyru (685424), Emin Karaman (685422)   +4 more
core   +1 more source

Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion

Biology, 2023
Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Damian Kołat, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

Electroclinical phenotypes—genetic characterization of developmental and epileptic encephalopathies in a cohort study

Epileptic Disorders, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman, Fulya Kurekci, Sinan Akbas, Ceyda Oney, Mehmet Akif Kilic, Hulya Maras Genc, Ayca Dilruba Aslanger, Edibe Pembegul Yildiz   +7 more
wiley   +1 more source

WWOX gene restoration prevents lung cancer growth in vitro and in vivo

, 2005
The WWOX (WW domain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of cancer, including lung cancer. We have examined the tumor suppressor function of WWOX in preclinical lung cancer models. The WWOX gene was
AMADORI D., TRAPASSO F., AQEILAN R. I., HUEBNER K., FABBRI M., ILIOPOULOS D., YENDAMURI S., HAN S. Y., CIMMINO A., CROCE, Carlo Maria, ZANESI N.   +10 more
core   +1 more source

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to Fibronectin via Integrin alpha(3)

, 2009
The WW domain-containing oxidoreductase (WWOX) gene Is located at FRA16D, a common fragile site involved in human cancer. Targeted deletion of Wwox in mice causes increased spontaneous tumor incidence, confirming that WWOX is a bona fide tumor suppressor
Janczar, Szymon, Muir, Morwenna, Ward, Carol, Zhang, Jieqing, Sun, Mingjun, Paige, Adam J. W., Gabra, Hani, Kuske, Barbara, Taylor, Karen J., Smyth, John F., Paige, Adam, Gourley, Charlie, Harrison, David J., Harrison, David J.; id_orcid   +13 more
core   +1 more source

Neuroimaging features of WOREE syndrome: a mini-review of the literature

Frontiers in Pediatrics, 2023
The WWOX gene encodes a 414-amino-acid protein composed of two N-terminal WW domains and a C-terminal short-chain dehydrogenase/reductase (SDR) domain. WWOX protein is highly conserved among species and mainly expressed in the cerebellum, cerebral cortex,
Laura Battaglia, Giovanna Scorrano, Rossana Spiaggia, Antonio Basile, Stefano Palmucci, Pietro Valerio Foti, Corrado Spatola, Michele Iacomino, Franco Marinangeli, Elisa Francia, Francesco Comisi, Antonio Corsello, Vincenzo Salpietro, Vincenzo Salpietro, Alessandro Vittori, Emanuele David   +15 more
doaj   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

WWOX tumor suppressor gene [PDF]

, 2008
Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias.
Zhang, Wei, Yang, Jilong
core  

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2328-2340, October 2026.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source