Results 61 to 70 of about 2,696,015 (152)

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Frontiers in Oncology, 2018
The WW domain–containing oxidoreductase (WWOX) gene encompasses a common fragile sites (CFS) known as FRA16D, and is implicated in cancer. WWOX encodes a 46kDa adaptor protein, which contains two N-terminal WW–domains and a catalytic domain at its C ...
Mayur Tanna, Rami I. Aqeilan, Rami I. Aqeilan   +2 more
doaj   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

, 2008
The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors.
Carlo M. Croce, Tripti Gaur, Hagan, John P., Gaur, Tripti, Gary S. Stein, Aqeilan, Rami I., Rami I. Aqeilan, Lee, Suk Hee, John P. Hagan, Hussain, Sadiq, Mohammad Q. Hassan, Suk-Hee Lee, Palumbo, Titziana, Lian, Jane B., Titziana Palumbo, Stefano Volinia, De Bruin, Alain, Jane B. Lian, Sadiq Hussain, Hassan, Mohammad Q., VOLINIA, Stefano, Stein, Gary S., Alain de Bruin, CROCE, Carlo Maria, Croce, Carlo M.   +24 more
core   +2 more sources

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

Frontiers in Oncology, 2019
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms such ...
Kevin M. McBride, Hyunsuk Kil, Yunxiang Mu, Joshua B. Plummer, Jaeho Lee, Maciej J. Zelazowski, Manu Sebastian, Martin C. Abba, C. Marcelo Aldaz   +8 more
doaj   +1 more source

Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization. [PDF]

PLoS ONE, 2016
Genomic alteration in head and neck squamous cell carcinoma (HNSCC) was studied in two cell line pairs (HN30-HN31 and HN4-HN12) using conventional C-banding, multiplex fluorescence in situ hybridization (M-FISH), and array comparative genomic ...
Worapong Singchat, Ekarat Hitakomate, Budsaba Rerkarmnuaychoke, Aorarat Suntronpong, Beiyuan Fu, Winai Bodhisuwan, Surin Peyachoknagul, Fengtang Yang, Sittichai Koontongkaew, Kornsorn Srikulnath   +9 more
doaj   +1 more source

Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review

Journal of Oral Pathology &Medicine, Volume 55, Issue 4, Page 439-447, April 2026.
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira, Reydson Alcides de Lima‐Souza, Moisés Willian Aparecido Gonçalves, Carlos Takahiro Chone, Arthur Antolini‐Tavares, Albina Altemani, Fernanda Viviane Mariano   +6 more
wiley   +1 more source

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma

, 2010
To evaluate the role of WWOX gene in human osteosarcoma, array comparative genomic hybridization on 10 frozen osteosarcoma specimens and immunohistochemical staining of 55 formalin-fixed and paraffin-embedded tissues for WWOX was performed.
Hu, Limei, Zheng, Hong, Li, Haixin, Trent, Jonathan, Yang, Da, Chen, Kexin, Yang, Jilong, Cogdell, David, Zhang, Wei, Du, Xiaoling, Pang, Yi, Wei Zhang, Xiaoling Du, Hong Zheng, Jonathan Trent, Haixin Li, Yi Pang, Kexin Chen, David Cogdell, Da Yang, Limei Hu, Jilong Yang   +21 more
core   +1 more source

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

Neurobiology of Disease, 2019
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C. Abba, Ashok K. Shetty, C. Marcelo Aldaz   +11 more
doaj   +1 more source

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy‐Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia

Molecular Genetics &Genomic Medicine, Volume 14, Issue 3, March 2026.
B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is a prevalent pediatric hematologic malignancy characterized by diverse chromosomal aberrations that significantly influence its prognosis. This study aimed to comprehensively characterize the genomic landscape of childhood BCP‐ALL in a cohort of 55 Malaysian patients.
Nor Soleha Mohd Dali, Nursaedah Abdullah Aziz, Muhamad Farid Zulkifle, Durar Aqilah Zamri, Nor Rizan Kamaluddin, Seoh‐Leng Yeoh, Betty Lee‐Sue Ho, Nazzlin Dizana Din, Azly Sumanty Ab Ghani, Wan Amal Hayati Wan Hassan, Zubaidah Zakaria, Ezalia Esa, Yuslina Mat Yusoff   +12 more
wiley   +1 more source