Results 61 to 70 of about 4,897 (187)

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

BMC Biology, 2018
Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand, Keltouma Driouch   +18 more
doaj   +1 more source

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Neurobiology of Disease, 2021
Summary: Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy.
Vanessa L. Breton, Mark S. Aquilino, Srinivasarao Repudi, Afifa Saleem, Shanthini Mylvaganam, Sara Abu-Swai, Berj L. Bardakjian, Rami I. Aqeilan, Peter L. Carlen   +8 more
doaj   +1 more source

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development [PDF]

, 2019
Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders.
Clifton, Nicholas E., Di Florio, Arianna, Hall, Jeremy, Hannon, Eilis, Harwood, Janet C., Holmans, Peter A., O'Donovan, Michael, Owen, Michael J., Pocklington, Andrew J., Thomas, Kerrie L., Walters, James T. R.   +10 more
core   +3 more sources

Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression

Frontiers in Neuroscience, 2023
IntroductionGlioblastoma (GBM) is notorious for its clinical and molecular heterogeneity, contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor suppressor genes important in nervous tissue or related pathologies, which was ...
Żaneta Kałuzińska-Kołat, Damian Kołat, Katarzyna Kośla, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors [PDF]

International Journal of Biological Sciences, 2014
WWOX, a gene that spans the second most common chromosomal fragile site (FRA16D), often exhibits homozygous deletions and translocation breakpoints under multiple cellular stresses induced by extrinsic or intrinsic factors, such as hypoxia, UV, and DNA damage regents.
Li, Juan, Liu, Jie, Ren, Yu, Yang, Jin, Liu, Peijun   +4 more
openaire   +2 more sources

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +1 more source

Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion

Biology, 2023
Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Damian Kołat, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias [PDF]

Oral Oncology, 2008
Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile site, are present in several malignant
Flávio Juliano, Pimenta, Gabriela Tavares, Cordeiro, Luiz Gustavo Garcia Santos, Pimenta, Michelle Beatriz, Viana, Joyce, Lopes, Marcus Vinícius, Gomez, C Marcelo, Aldaz, Luiz, De Marco, Ricardo Santiago, Gomez   +8 more
openaire   +2 more sources

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content [PDF]

, 2009
Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis.
Timo K Nykopp, Kirsi Rilla, Reijo Sironen, Markku I Tammi, Raija H Tammi, Kirsi Hämäläinen, Anna-Mari Heikkinen, Marja Komulainen, Veli-Matti Kosma, Maarit Anttila   +9 more
core   +2 more sources