Results 81 to 90 of about 2,696,015 (152)

HYAL-2–WWOX–SMAD4 signaling in cell death and anticancer response

Frontiers in Cell and Developmental Biology, 2016
Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are essential for the metabolism of hyaluronan (HA).
Li-Jin Hsu, Ming-Fu Chiang, Chun-I Sze, Wan-Pei Su, Ye Vone Yap, I-Ting Lee, Hsiang-Ling Kuo, Nan-Shan Chang   +7 more
doaj   +1 more source

Hematolojik milignitelerde wwox’ ın prognostik öneminin araştırılması [PDF]

, 2019
WW alanı içeren oksidoredüktaz (WW domain-containing oxidoreductase, WWOX) geni kromozom 16q23.3-q24.1 bölgesinde bulunmaktadır ve yaygın kromozomal frajil bölge, FRA16D, içermektedir.
Hancı, Halil
core   +1 more source

Genetic alterations of the WWOX gene in breast cancer

, 2011
FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome and two tumor suppressor genes FHIT (Fragile Histidine Triad) and WWOX (WW domain-containing oxidoreductase gene) map to this sites.
Buyru, Nur, Nejat Dalay, Seda Ekizoglu, Muslumanoglu, Mahmut Ebudeccane, Ekizoglu, Seda, Nur Buyru, Mahmut Muslumanoglu, Dalay, Nejat, Muslumanoglu, Mahmut   +8 more
core   +1 more source

Analysis of WWOX Gene Associated with Cancer [PDF]

Cancer is a disease caused by abnormal cell growth and uncontrollable spread throughout one’s body. According to the World Health Organization, about 1 in 5 people develop cancer: 1 in 9 in males and 1 in 12 in females (WHO).
Vanterpool, Elaine, Redley, Jovaughn
core  

WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy

Journal for ImmunoTherapy of Cancer
Background Immune checkpoint inhibitors (ICIs) are therapeutically effective for hepatocellular carcinoma (HCC) but are individually selective. This study examined the role of specific common fragile sites (CFSs) related gene in HCC immunotherapy.Methods
Min Xu, Mien-Chie Hung, Qiang Zhou, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Ning Ren, Chenhao Zhou, Jialei Weng, Shaoqing Liu, Minghao Xu, Shiguang Yang, Zhiqiu Hu   +13 more
doaj   +1 more source

Loss of fragile WWOX gene leads to senescence escape and genome instability. [PDF]

Cell Mol Life Sci, 2023
Cheng HC, Huang PH, Lai FJ, Jan MS, Chen YL, Chen SY, Chen WL, Hsu CK, Huang W, Hsu LJ.   +9 more
europepmc   +1 more source

Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma [PDF]

, 2012
Osteosarcoma is the most common primary bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and bone ...
Lian, Jane B., Aqeilan, Rami I., Kurek, Kyle C., Stein, Gary S., Del Mare, Sara   +4 more
core  

Wwox inactivation enhances mammary tumorigenesis [PDF]

, 2011
Breast cancer is the leading cause of cancer-related death in women worldwide. Expression of the WWOX tumor suppressor is absent or reduced in a large proportion of breast tumors suggesting that loss of WWOX may contribute to breast tumorigenesis ...
Salah, Z, Aqeilan, RI, Maly, B, Abu-Odeh, M, Tufail, R, Croce, CM, Abdeen, SK, Smith, Y, Zanesi, N, Nawaz, Z   +9 more
core   +1 more source

Novel Mutation With Literature Review WW Domain-Containing Oxidoreductase (WWOX) Gene. [PDF]

Cureus, 2022
Sukkar G, Alzahrani RM, Altirkistani BA, Al Lohaibi RS.   +3 more
europepmc   +1 more source

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

, 2018
Liver cancer is one of the most lethal malignancies with very poor prognosis once diagnosed. The most common form of liver cancer is hepatocellular carcinoma (HCC). The WW domain-containing oxidoreductase (WWOX) is a large gene that is often perturbed in
Muhannad Abu-Remaileh, Eli Pikarsky, Rami I. Aqeilan, Abed Khalaileh   +3 more
core   +1 more source