Results 101 to 110 of about 4,897 (187)

Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins

European Journal of Immunology, Volume 55, Issue 12, December 2025.
Unannotated splicing and translation of non‐canonical open reading frames generate a diverse repertoire of cryptic proteins. Most are rapidly degraded, rendering them possible MHC‐I substrates. Yet, a subpopulation can adopt stable structures and impart advantageous functions.
Emma G. Bawden, Sebastian Amigorena, Yago A. Arribas   +2 more
wiley   +1 more source

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

BMC Cancer, 2005
Background The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrangement in ovarian, breast ...
Liu Jinsong, Godwin Andrew K, Klein-Szanto Andres JP, Page Robert, Kil Hyunsuk, Abba Martín C, Ludes-Meyers John H, Rosen Daniel G, Nunez María I, Mills Gordon B, Aldaz C Marcelo   +10 more
doaj   +1 more source

Mouse Models of Osteosarcoma: Unraveling Disease Mechanisms and Accelerating Drug Discovery and Development

Cancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background Osteosarcoma is the most frequent primary bone malignancy, affecting mainly children, adolescents, and young adults. For the past 40 years, improvements in the survival of patients with osteosarcoma have been minimal, primarily as a consequence of the lack of systemic therapy options beyond traditional cytotoxic agents.
Staci L. Haney, Sarah A. Holstein
wiley   +1 more source

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]

, 2019
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, García Rodríguez, JL, Serrano Macía, M., Zubiete Franco, I   +4 more
core   +1 more source

Long‐term outcomes of a cohort of patients with pharmacoresistant neonatal epilepsy and negative brain MRI

Epilepsia Open, Volume 10, Issue 5, Page 1605-1616, October 2025.
Abstract Objective Neonatal seizures initiate the onset of epilepsy in less than 20% of cases. Establishing accurate and prompt diagnosis for precision medicine, offering tailored care, and informing families about neurodevelopmental prognosis represents a significant challenge.
Thibault Beretti, William Rozalen, Laurent Villard, Florence Riccardi, Geraldine Daquin, Anne Lepine, Nathalie Villeneuve, Mathieu Milh, Béatrice Desnous   +8 more
wiley   +1 more source

Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells [PDF]

, 2018
Indexación: Scopus.Departamento de Oncología Básico-Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile 2Comisión Chilena de Energía Nuclear, Santiago, Chile 3Center for Research and Applications in Plasma Physics and Pulsed Power, P4 ...
Andaur, R., Armisen, R., Marcelain, K., Moreno, J., Soto, L., Tapia, J.C.   +5 more
core   +1 more source

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez, Luciana Bertholim Nasciben, Sofia Moura, Lauren Coombs, Farid Rajabli, Brooke A. DeRosa, Patrice L. Whitehead, Larry D. Adams, Takiyah D. Starks, Pedro R. Mena, Maryenela Illanes‐Manrique, Sergio Tejada, Goldie S. Byrd, Allison Caban‐Holt, Michael L Cuccaro, Katalina McInerney, Mario R. Cornejo‐Olivas, Briseida E. Feliciano‐Astacio, Liyong Wang, Maria C. Robayo, Wanying Xu, Fulai Jin, Margaret A. Pericak‐Vance, Anthony J. Griswold, Juan I. Young, Derek M. Dykxhoorn, Jeffery M. Vance   +26 more
wiley   +1 more source

miRNA Signature of Schwannomas: Possible Role(s) of “Tumor Suppressor” miRNAs in Benign Tumors [PDF]

, 2013
miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system.
Breakefield, Xandra Owens, Erkan, Erdogan Pekcan, Saydam, Okay   +2 more
core   +1 more source

Transcriptomic analyses of regenerating adult feathers in chicken [PDF]

, 2015
Transcriptome Expression Data. Table of mapped reads to Galgal4 transcripts for all 15 data sets. FPKM (Fragments per kilobase of exon per million fragments mapped): normalized transcript abundance values for each gene in the indicated tissues.
Chen Siang Ng, Cheng-Ming Chuong, Chi-Tang Mao, Chih-Feng Chen, Chih-Kuan Chen, Di-Rong Chen, Jiun-Jie Chen, Kai-Jung Yang, Mei-Yeh Jade Lu, Ping Wu, Siao-Man Wu, Tsung-Che Tu, Wen-Hsiung Li, Wen-Lang Fan, Yu-Ting Lai, Yuan-An Sha, Ze-Shiang Lin   +16 more
core   +6 more sources

Intermediate Conductance Calcium‐Dependent Potassium Channel (KCa3.1) Interacting Proteins Using Turboid‐Based Proximity Labeling Technology: Insights Into Interactome and Related Signaling Pathways in Pancreatic Tumors

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT KCa3.1 ion channel is a calcium‐activated potassium channel expressed in various tissues, showing dual localization to the plasma membrane and to mitochondria. This channel is highly expressed in numerous cancers and has been implicated in the regulation of proliferation and migration.
Veronica Carpanese, Soha Sadeghi, Luca Matteo Todesca, Ildikò Szabò, Vanessa Checchetto   +4 more
wiley   +1 more source