Results 101 to 110 of about 2,696,015 (152)

Case report: Adult patient with WWOX developmental and epileptic encephalopathy: 40 years of observation

Frontiers in Genetics
WWOX developmental and epileptic encephalopathy is characterised by drug-resistant epilepsy with onset within the first year of life and severe psychomotor developmental delay.
Anna Teplyshova, Artem Sharkov, Artem Sharkov, Artem Sharkov   +3 more
doaj   +1 more source

Data_Sheet_1_The WWOX Gene Influences Cellular Pathways in the Neuronal Differentiation of Human Neural Progenitor Cells.pdf

, 2019
The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis
Katarzyna Kośla (6688535), Magdalena Orzechowska (4640353), Andrzej K. Bednarek (4640356), Elżbieta Płuciennik (6688541), Ewa Styczeń-Binkowska (7329143), Magdalena Nowakowska (3549914)   +5 more
core   +1 more source

Immunohistochemical assessment of tumor suppressor gene Wwox in relation to proliferative marker KI67 proteins expression in giant cell lesions of the jaws and giant cell tumor of long bones

Journal of Baghdad College of Dentistry, 2015
Background: Peripheral giant cell lesion (PGCL) and central giant cell lesion (CGCL) of the jaws have a distinct clinical behavior.Giant cell tumour (GCT) is a benign locally aggressive neoplasm affects the long bones.
Muna S Merza
doaj  

Immunohistochemical evaluation of FHIT and WWOX expression in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

Journal of Baghdad College of Dentistry, 2014
Background: Oral squamous cell carcinoma is the most prevalent malignant neoplasm of the oral cavity which results from accumulated genetic and epigenetic alterations. It is not always inexorable and may be reversible if early intervention in the process
Dhaffar A Majbil, Muna S Merza
doaj  

Study on expression and significance of tumor suppressor gene WWOX in hepatocellular carcinoma tissues by real-time fluorescent quantitative PCR

, 2007
目的检测染色体普通型脆性位点FRA16D(16q23.3-q24.1)上WWOX(WW domain containing oxidoreductase)基因在原发性肝细胞癌(HCC)中的表达及意义。方法用RT-PCR、荧光定量PCR方法分别对40例原发性肝细胞癌癌组织(以下简称肝癌组织)、癌旁组织中WWOX基因的Δ6-8变异情况及其mRNA表达差异进行检测。结果WWOX mRNA在肝癌组织的表达(0.318±0.0559)显著低于癌旁组织(1.0 ...
张忠英, 傅锦波, 李涌, 游攀, 陈锦萍, 黄建炜, 王效民, 吴绍峰   +7 more
core  

The Role of WWOX Gene Variant in Hypospadias and 46,XY Disorders of Sexual Development. [PDF]

Reprod Sci
Denkboy Ongen Y, Tezcan-Unlu H, Unal U, Efendi-Erdem E, Cecener G, Eren E.   +5 more
europepmc   +1 more source

Early infantile-onset epileptic encephalopathy 28 due to a homozygous microdeletion involving the WWOX gene in a region of uniparental disomy. [PDF]

Hum Mutat, 2019
Davids M, Markello T, Wolfe LA, Chepa-Lotrea X, Tifft CJ, Gahl WA, Malicdan MCV.   +6 more
europepmc   +1 more source

Neuron-specific WWOX gene therapy produces dose-dependent, durable rescue in a model of WWOX-related epileptic encephalopathy. [PDF]

Mol Ther Adv
Obeid M, Akkawi R, Repudi S, Singh PK, Abudiab B, Jebara T, Berent A, Brennan T, Weiss Y, Shekh-Ahmad T, Aqeilan RI.   +10 more
europepmc   +1 more source

Alzheimer's disease risk gene <i>Wwox</i> controls amyloid pathology through metabolic reprogramming. [PDF]

Brain Commun
Lucas-Clarke HJ, Maddison DC, Amadio L, Buhl E, Regnault C, Peters OM, Hodge JJL, Smith GA.   +7 more
europepmc   +1 more source

<i>WWOX/HIF1A</i> Balance Delineates Context-Dependent Molecular States in Breast Cancer Subtypes and Ovarian Carcinoma. [PDF]

Int J Mol Sci
Hammouz RY, Maciejek K, Bednarek AK.
europepmc   +1 more source