PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome
Scientific Reports, 2017 The long non-coding RNA PARTICLE (Gene PARTICL- ‘Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) partakes in triple helix (triplex) formation, is transiently elevated following low dose irradiation and regulates transcription of its ...
Valerie Bríd O’Leary +12 more
doaj +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, Volume 12, Issue 29, August 7, 2025.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
HYAL-2–WWOX–SMAD4 signaling in cell death and anticancer response
Frontiers in Cell and Developmental Biology, 2016 Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are essential for the metabolism of hyaluronan (HA).
Li-Jin Hsu +7 more
doaj +1 more source
Hypoxic conditions differentially regulate TAZ and YAP in cancer cells [PDF]
, 2014 The Hippo-YAP pathway is altered and implicated as an oncogenic signaling pathway in many human cancers. Hypoxia is an important microenvironmental factor that promotes tumorigenesis.
Cai, Qingchun, Xu, Yan, Yan, Libo
core +1 more source
Epilepsia Open, Volume 10, Issue 4, Page 1065-1073, August 2025.Abstract Objective Genetic testing is now included in the diagnostic assessment of childhood onset epilepsies. We evaluated the yield of a targeted next generation sequencing (TNGS) panel dedicated to pediatric epilepsies. Methods We tested by TNGS panel 1000 consecutive patients presenting with childhood onset epilepsies and including mainly patients ...
Giulia Barcia +21 more
wiley +1 more source
Characterization of 1-ACBP B-ACBP and PBR in oesophageal cancer [PDF]
, 2006 Faculty of Science; School of molecular and Cell Biology; MSC DissertationBackground: Cancer of the oesophagus ranks as the ninth most common malignancy in the world, and recent evidence shows that its incidence is increasing.
McCabe, Michelle Lynn
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Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype [PDF]
, 2017 The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis.
Hascall, Vincent +6 more
core +2 more sources
The role of AP-2 alpha in predicting response to chemotherapy in breast cancer patients [PDF]
, 2011 Breast cancer is the most frequent cancer occurring in women in Europe1. In Switzerland, the incidence in 2009 was 32,9% and it was the primary cause of cancer related death in women, with a mortality rate of 19.2%2. The management of this cancer depends
SICHITIU, J.
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Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons [PDF]
, 2016 Postnatal maturation of the neurons whose main phenotype and basic synaptic contacts are already established includes neuronal growth, refinement of synaptic contacts, final steps of differentiation, programmed cell death period (PCD) etc.
Jaan ePalgi +4 more
core +1 more source
WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC)
Tumor Biology, 2010 Lung cancer is the most common cause of cancer-related death worldwide and, like many other cancers, is affected by different genetic, epigenetic, and environmental factors. The WW domain-containing oxidoreductase (WWOX) gene is a tumor-suppressor gene located on chromosome 16q23.3-24.1, and it has been shown that it loses its function due to ...
Onur, Baykara +5 more
openaire +2 more sources