Results 81 to 90 of about 1,533 (168)

Sequence-specific backbone 1H, 13C and 15N assignments of the catalytic domain of the Escherichia coli protein tyrosine kinase, Wzc [PDF]

open access: yesBiomolecular NMR Assignments, 2012
Protein tyrosine kinases in bacteria are structurally and functionally distinct from their eukaryotic counterparts. The largest family of bacterial tyrosine kinases, the BY-kinase family, is highly conserved in Gram-negative and Gram-positive species, and plays a central role in biofilm and capsule formation.
Deniz B, Temel   +2 more
openaire   +2 more sources

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

open access: yesAnnals of the New York Academy of Sciences, Volume 1548, Issue 1, Page 80-98, June 2025.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka   +3 more
wiley   +1 more source

Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
Graphical Abstract ABSTRACT Besides surgical decompression, neuroprotection and neuroinflammation reduction are critical for acute spinal cord injury (SCI). In this study, we prepared small extracellular vesicles (sEVs) from immortalised mesenchymal stem cells overexpressing brain‐derived neurotrophic factor (BDNF) and evaluated whether intranasal ...
Zhonghai Huang   +18 more
wiley   +1 more source

Image_7_Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.TIF

open access: yes, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xiaokui Zhu (11526877)   +8 more
core   +1 more source

Mantle Dynamics in the Mediterranean and Plate Motion of the Adriatic Microplate: Insights From 3D Thermomechanical Modeling

open access: yesGeochemistry, Geophysics, Geosystems, Volume 26, Issue 3, March 2025.
Abstract The motion of the Adriatic microplate is thought to be highly sensitive to the surrounding subduction zones and the convergence of Africa and Eurasia. However, our understanding of the mantle dynamics in the Mediterranean region and its effect on plate motion remains incomplete. Here, we present a large set of 3D thermomechanical models of the
Christian Schuler   +4 more
wiley   +1 more source

Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU

open access: yesInfection and Drug Resistance, 2022
Xiang-Rong Bai,1,* Jing-Rong Cao,2,* Zhi-Zhou Wang,1 Wen-Chao Li,1 Dian-Dian Chen,2 Ran Lou,3 Xin Qu,4 Su-Ying Yan1 1Department of Pharmacy, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing,
Bai XR   +7 more
doaj  

Cognitive Impairment in Chronic Kidney Disease Across Different Stages: The Role of Structural and Perfusion‐Driven Functional Connectivity Changes

open access: yesBrain and Behavior, Volume 15, Issue 2, February 2025.
Patients with CKD, particularly in early stages, may exhibit changes in GMV and CBF, which can lead to decreased FC between the fusiform gyrus and cognitive‐related regions in advanced‐stage CKD. CKD, chronic kidney disease; CKD3b‐5, patients with stage 3b‐5 chronic kidney disease; CKD1‐3a, patients with stage 1‐3a chronic kidney disease; HC, healthy ...
Xiaoyan Bai   +8 more
wiley   +1 more source

DataSheet1_The pharmacokinetic study of tacrolimus and Wuzhi capsule in Chinese liver transplant patients.docx

open access: yes, 2022
Objectives: Wuzhi Capsule (WZC) is often administrated with tacrolimus in liver transplant patients to reduce the toxicity of tacrolimus and relieve the financial burden of patients. We aimed to investigate the interaction between Wuzhi Capsule (WZC) and
Binguo Liu (13797355)   +7 more
core   +1 more source

FBXO38 Regulates Nox1 Stability to Reduce Vascular Endothelial Damage Induced by Low Oscillatory Shear Stress

open access: yesCardiovascular Therapeutics, Volume 2025, Issue 1, 2025.
Oxidative stress and endothelial dysfunction are critical drivers of atherosclerosis, but the mechanisms regulating oxidative stress under disturbed flow conditions remain incompletely understood. The ubiquitin–proteasome system, particularly E3 ubiquitin ligases, may play a pivotal role in modulating these processes.
Wan-li Yu   +11 more
wiley   +1 more source

Image_5_Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.TIF

open access: yes, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xiaokui Zhu (11526877)   +8 more
core   +1 more source

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