Results 71 to 80 of about 1,511 (146)

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

Annals of the New York Academy of Sciences, Volume 1548, Issue 1, Page 80-98, June 2025.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka, Emily L. Kinney, Brooke E. Ryan, Laura A. Mike   +3 more
wiley   +1 more source

Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys

Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
Graphical Abstract ABSTRACT Besides surgical decompression, neuroprotection and neuroinflammation reduction are critical for acute spinal cord injury (SCI). In this study, we prepared small extracellular vesicles (sEVs) from immortalised mesenchymal stem cells overexpressing brain‐derived neurotrophic factor (BDNF) and evaluated whether intranasal ...
Zhonghai Huang, Jing Li, Jin Wo, Cheng‐Lin Li, Zi‐Cong Wu, Xiao‐Hui Deng, Yaying Liang, Fuxiang Li, Boli Chen, Bin Jia, Lu Wang, Ying Wang, Guodong Sun, Zhizhong Li, Hui Zhu, James D Guest, Kwok‐Fai So, Qing‐Ling Fu, Libing Zhou   +18 more
wiley   +1 more source

Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU

Infection and Drug Resistance, 2022
Xiang-Rong Bai,1,* Jing-Rong Cao,2,* Zhi-Zhou Wang,1 Wen-Chao Li,1 Dian-Dian Chen,2 Ran Lou,3 Xin Qu,4 Su-Ying Yan1 1Department of Pharmacy, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing,
Bai XR, Cao JR, Wang ZZ, Li WC, Chen DD, Lou R, Qu X, Yan SY   +7 more
doaj  

Image_2_Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.TIF

, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xiaokui Zhu (11526877), Guohui Han (11526880), Xu Jia (187142), Xianggui Yang (7698728), Ying Xu (9172), Lingjie Song (1846537), Yan Wan (342234), Jinwei Huang (355364), Guangxin Luan (594559)   +8 more
core   +1 more source

Mantle Dynamics in the Mediterranean and Plate Motion of the Adriatic Microplate: Insights From 3D Thermomechanical Modeling

Geochemistry, Geophysics, Geosystems, Volume 26, Issue 3, March 2025.
Abstract The motion of the Adriatic microplate is thought to be highly sensitive to the surrounding subduction zones and the convergence of Africa and Eurasia. However, our understanding of the mantle dynamics in the Mediterranean region and its effect on plate motion remains incomplete. Here, we present a large set of 3D thermomechanical models of the
Christian Schuler, Boris J. P. Kaus, Eline Le Breton, Nicolas Riel, Anton A. Popov   +4 more
wiley   +1 more source

Image_1_Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.TIF

, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xiaokui Zhu (11526877), Guohui Han (11526880), Xu Jia (187142), Xianggui Yang (7698728), Ying Xu (9172), Lingjie Song (1846537), Yan Wan (342234), Jinwei Huang (355364), Guangxin Luan (594559)   +8 more
core   +1 more source

Cognitive Impairment in Chronic Kidney Disease Across Different Stages: The Role of Structural and Perfusion‐Driven Functional Connectivity Changes

Brain and Behavior, Volume 15, Issue 2, February 2025.
Patients with CKD, particularly in early stages, may exhibit changes in GMV and CBF, which can lead to decreased FC between the fusiform gyrus and cognitive‐related regions in advanced‐stage CKD. CKD, chronic kidney disease; CKD3b‐5, patients with stage 3b‐5 chronic kidney disease; CKD1‐3a, patients with stage 1‐3a chronic kidney disease; HC, healthy ...
Xiaoyan Bai, Lijun Song, Xu Liu, Wenbo Yang, Mingan Li, Boyan Xu, Zhenghan Yang, Zhen‐Chang Wang, Hao Wang   +8 more
wiley   +1 more source

K-PAM: a unified platform to distinguish Klebsiella species K- and O-antigen types, model antigen structures and identify hypervirulent strains

Scientific Reports, 2020
A computational method has been developed to distinguish the Klebsiella species serotypes to aid in outbreak surveillance. A reliability score (estimated based on the accuracy of a specific K-type prediction against the dataset of 141 distinct K-types ...
L. Ponoop Prasad Patro, Karpagam Uma Sudhakar, Thenmalarchelvi Rathinavelan   +2 more
doaj   +1 more source

Samen op weg naar minder: een kwaliteitsverbeteringsproject over het gebruik van psychofarmaca in een woonzorgcentrum in Vlaanderen

, 2018
Psychofarmaca worden door bewoners van het woonzorgcentra (WZC) veel en vaak onoordeelkundig gebruikt, wat hoge kosten en bijwerkingen met zich meebrengt.
Petrovic, Mirko, Azermai, Majda, De Vriendt, Patricia, De Meester, Dirk, Peeters, Laurine, Elseviers, Monique   +5 more
core   +1 more source

Image_7_Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene.TIF

, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xiaokui Zhu (11526877), Guohui Han (11526880), Xu Jia (187142), Xianggui Yang (7698728), Ying Xu (9172), Lingjie Song (1846537), Yan Wan (342234), Jinwei Huang (355364), Guangxin Luan (594559)   +8 more
core   +1 more source