Hypermucoviscosity in Klebsiella pneumoniae: Manifestation, Regulation, and Roles in Pathogenesis. [PDF]
Journal of BacteriologyIn recent years, Klebsiella pneumoniae (Kpn) has evolved into a global public health threat. Convergent Kpn lineages that are both hypervirulent and multidrug-resistant have emerged and can cause community-acquired, drug-resistant infections, with ...
Shankar Manoharan
exaly +6 more sources
Microbiology Spectrum, 2022 Klebsiella pneumoniae can be broadly classified into classical strains that cause drug-resistant, hospital-associated infections and hypervirulent strains that cause invasive, community-acquired, drug-susceptible infections.
Shankar Manoharan +1 more
exaly +6 more sources
The Hypermucoviscosity of Hypervirulent K. Pneumoniae Confers the Ability to Evade Neutrophil-Mediated Phagocytosis [PDF]
Virulence, 2021 Hypervirulent Klebsiella pneumoniae (HvKP), which causes highly fatal infections, is a new threat to human health. In an attempt to investigate the underlying mechanisms of resistance to neutrophil-mediated killing and hence expression of high-level ...
Qi Xu, Sheng Chen, Xuemei Yang
exaly +7 more sources
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionHypermucoviscous Klebsiella pneumoniae (HmKp) poses an emerging and highly pathogenic global health threat. This study aimed to investigate the clinical and genomic characteristics of HmKp isolates to better understand the virulence ...
Shiyu Qin, Tianye Jia, Meiling Jin
exaly +5 more sources
VirulenceHypervirulent Klebsiella pneumoniae (hvKP), a pathogen responsible for severe invasive infections, exhibits a hypermucoviscosity (HMV) phenotype that is closely associated with its virulence. While fumarate and nitrate reduction regulator (FNR), a global
Pin-Jia Wang, Chengbin Xie
exaly +5 more sources
Overcoming phagocytosis resistance of hypervirulent Klebsiella pneumoniae by directly targeting capsules [PDF]
Microbial CellCapsular polysaccharides (CPS) are key virulence factors in Klebsiella pneumoniae and are closely associated with the K1 and K2 hypervirulent serotypes. Herein, we demonstrate that introducing nonspecific RNA (sgRNA) into K.
Shogo Tsubaki +6 more
doaj +2 more sources
Convergence of multidrug resistance with biofilm formation and hypermucoviscosity in Klebsiella pneumoniae from tertiary-care hospitals in Northwestern Pakistan [PDF]
Antimicrobial Stewardship & Healthcare EpidemiologyThis multicenter study describes the convergence of multidrug resistance, biofilm formation, and hypermucoviscosity in Klebsiella pneumoniae clinical isolates from tertiary-care hospitals in Pakistan.
Aiman Waheed +4 more
doaj +2 more sources
Closely related ST11 Klebsiella pneumoniae isolates with transient attenuation and re-emergence of carbapenem resistance during prolonged hospitalization: a case report [PDF]
Frontiers in ImmunologyBackgroundApparent transitions in carbapenem susceptibility among sequential Klebsiella pneumoniae isolates are often interpreted as strain replacement.
Mingquan Zeng +11 more
doaj +2 more sources
Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae [PDF]
iMetaThe intestinal microbiota acts as a barrier against pathogen colonization, yet how specific ecological perturbations shape the evolutionary fate of invading pathogens remains unclear.
Carey Lim +9 more
doaj +2 more sources
Distinct and shared impacts of virulence plasmids on the phenotype and transcriptome in convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae [PDF]
Microbiology SpectrumThe global rise of convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a major clinical challenge, yet the role of virulence plasmids (pVirs) in shaping bacterial physiology and pathogenicity remains incompletely ...
Mingju Hao +8 more
doaj +2 more sources