Results 1 to 10 of about 1,227 (123)

Overcoming phagocytosis resistance of hypervirulent Klebsiella pneumoniae by directly targeting capsules [PDF]

Microbial Cell
Capsular polysaccharides (CPS) are key virulence factors in Klebsiella pneumoniae and are closely associated with the K1 and K2 hypervirulent serotypes. Herein, we demonstrate that introducing nonspecific RNA (sgRNA) into K.
Shogo Tsubaki, Touya Toyomoto, Rika Tanaka, Jin Imai, Juntaro Matsuzaki, Katsuto Hozumi, Hitoshi Tsugawa   +6 more
doaj   +2 more sources

Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length

MBio, 2023
Klebsiella pneumoniae is a leading cause of nosocomial infections, including pneumonia, bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the high prevalence of resistance to frontline antibiotics, including ...
Olga Ovchinnikova, Chris Whitfield, Kimberly A Walker   +2 more
exaly   +3 more sources

Clinical and genomic analysis of hypermucoviscous Klebsiella pneumoniae isolates: Identification of new hypermucoviscosity associated genes

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionHypermucoviscous Klebsiella pneumoniae (HmKp) poses an emerging and highly pathogenic global health threat. This study aimed to investigate the clinical and genomic characteristics of HmKp isolates to better understand the virulence ...
Shiyu Qin, Fangni Liu, Tianye Jia
exaly   +3 more sources

Unusual Hypermucoviscous Clinical Isolate of Klebsiella pneumoniae with No Known Determinants of Hypermucoviscosity

Microbiology Spectrum, 2022
Klebsiella pneumoniae can be broadly classified into classical strains that cause drug-resistant, hospital-associated infections and hypervirulent strains that cause invasive, community-acquired, drug-susceptible infections.
Karthikeyan Sivashanmugam
exaly   +3 more sources

Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis [PDF]

Journal of Bacteriology
In recent years, Klebsiella pneumoniae (Kpn) has evolved into a global public health threat. Convergent Kpn lineages that are both hypervirulent and multidrug-resistant have emerged and can cause community-acquired, drug-resistant infections, with ...
Tamal Dey, Manoharan Shankar
doaj   +2 more sources

The hypermucoviscosity of hypervirulent K. pneumoniae confers the ability to evade neutrophil-mediated phagocytosis

Virulence, 2021
Hypervirulent Klebsiella pneumoniae (HvKP), which causes highly fatal infections, is a new threat to human health. In an attempt to investigate the underlying mechanisms of resistance to neutrophil-mediated killing and hence expression of high-level ...
Qi Xu, Sheng Chen, Xuemei Yang
exaly   +2 more sources

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections. [PDF]

Clin Transl Sci
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Ali L, Sokhn ES, Khalil C, Saleh FA.
europepmc   +2 more sources

Convergence of multidrug resistance with biofilm formation and hypermucoviscosity in Klebsiella pneumoniae from tertiary-care hospitals in Northwestern Pakistan [PDF]

Antimicrobial Stewardship & Healthcare Epidemiology
This multicenter study describes the convergence of multidrug resistance, biofilm formation, and hypermucoviscosity in Klebsiella pneumoniae clinical isolates from tertiary-care hospitals in Pakistan.
Aiman Waheed, Taj Ali Khan, Sajjad Ahmad, Fahad Ahmed, Zahoor Khan   +4 more
doaj   +2 more sources

Ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae accompanied hypermucoviscosity acquisition [PDF]

BMC Microbiology
Background Antimicrobial resistance and bacterial hypermucoviscosity, associated with escalating production of capsules, constitute major challenges for the clinical management of Klebsiella pneumoniae (K. pneumoniae) infections.
Yingyi Guo, Jiong Wang, Likang Yao, Yijing Wang, Yan Zhang, Chuyue Zhuo, Xu Yang, Feifeng Li, Jiahui Li, Baomo Liu, Nanhao He, Jiakang Chen, Shunian Xiao, Zhiwei Lin, Chao Zhuo   +14 more
doaj   +2 more sources

Antimicrobial Resistance, Virulence, and Genomic Characteristics of <i>Klebsiella pneumoniae</i> Isolated From Four Host Sources in Northeast China. [PDF]

Transbound Emerg Dis
Klebsiella pneumoniae is an important emerging pathogen leading to serious clinical outcomes as the multidrug‐resistant (MDR) isolates arise. While K. pneumoniae is a well‐known pathogen in human clinical settings, its risks in nonhuman hosts and potential for cross‐species transmission remain poorly understood. In this study, we performed whole‐genome
Xu Q, Fan C, Liu Y, Lu X, Song W, Du S, Zhu Y, Xie F, Zhang W.   +8 more
europepmc   +2 more sources