Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex [PDF]
Nature CommunicationsCapsular polysaccharides (CPS) are key virulence determinants, constituting the protective capsule that surrounds bacterial pathogens. Here, we present the complete cryo-EM structure of Gram-negative bacterial CPS secretion machinery formed by the E ...
Christian Sieben +2 more
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The wzc mutation mediates virulence changes in K1-type Klebsiella pneumoniae within the same patient [PDF]
Frontiers in MicrobiologyHypervirulent Klebsiella pneumoniae (hvKp) is a major pathogen causing community-acquired infections, particularly severe diseases such as liver abscesses. Although extensive research has been conducted on the virulence mechanisms of hvKp and the genetic
Ye Jin, Zhijiang Xu
exaly +4 more sources
Adaptive attenuation of virulence mediated by Wzc mutation in ST11-KL47 Carbapenem-resistant Klebsiella pneumonia [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe impact of the hypermucoviscosity (HMV) phenotype in ST11-KL47 carbapenem-resistant Klebsiella pneumoniae (CRKp) pathogenicity warrants investigation for public health risk assessment.MethodsWe analyzed 230 clinical ST11-KL47 CRKp to ...
Yufeng Dai +12 more
exaly +4 more sources
Molecular basis for the phosphorylation of bacterial tyrosine kinase Wzc [PDF]
Nature CommunicationsThe regulation of polymerisation and translocation of biomolecules is fundamental. Wzc, an integral cytoplasmic membrane tyrosine autokinase protein serves as the master regulator of the biosynthesis and export of many bacterial capsular polysaccharides ...
Jiwei Liu
exaly +3 more sources
Architecture of the Wza-Wzc complex that mediates colanic acid translocation across the cell envelope in Gram-negative bacteria [PDF]
Nature CommunicationsThe Wzx/Wzy-dependent pathway is a highly conserved mechanism for bacterial polysaccharide biosynthesis. This pathway is exemplified by the assembly and export of colanic acid mediated by the Wza-Wzc complex.
Jiao Liu +7 more
doaj +2 more sources
MSphere, 2023 Klebsiella pneumoniae is a hospital-associated pathogen primarily causing urinary tract infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the hypervirulent strains, causing invasive community-acquired infections, and the ...
Saroj Khadka +2 more
exaly +3 more sources
Capsular Types of Klebsiella pneumoniae Revisited by wzc Sequencing [PDF]
PLoS ONE, 2013 Capsule is an important virulence factor in bacteria. A total of 78 capsular types have been identified in Klebsiella pneumoniae. However, there are limitations in current typing methods. We report here the development of a new genotyping method based on
Yi-Jiun Pan +2 more
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The molecular basis of regulation of bacterial capsule assembly by Wzc
Nature Communications, 2021 The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export.
James H Naismith +2 more
exaly +2 more sources
Frontiers in Microbiology, 2021 Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Xu Jia, Xianggui Yang, Lingjie Song
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Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release [PDF]
Microbiology SpectrumCarbapenem-resistant Klebsiella pneumoniae (CRKP) ST11-KL64 has emerged as the dominant subclone in China. Mutations in Wzc confer a hypermucoviscous (HMV) phenotype and enhanced virulence, but how these mutations regulate capsular polysaccharide (CPS ...
Huanhuan Yan +6 more
doaj +2 more sources