Results 41 to 50 of about 1,533 (168)

Structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb

Proceedings of the National Academy of Sciences, 2022
Bacterial tyrosine kinases (BY-kinases) comprise a family of protein tyrosine kinases that are structurally distinct from their functional counterparts in eukaryotes and are highly conserved across the bacterial kingdom. BY-kinases act in concert with their counteracting phosphatases to regulate a variety of cellular processes ...
Sébastien Alphonse, Imane Djemil, Andrea Piserchio, Ranajeet Ghose   +3 more
openaire   +2 more sources

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients

Microbiology Spectrum, 2022
Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang, Jinru Xie, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, Hui Wang   +8 more
doaj   +1 more source

Tyrosine-kinase Wzc fromEscherichia colipossesses an ATPase activity regulated by autophosphorylation [PDF]

FEMS Microbiology Letters, 2007
The catalytic mechanism of bacterial tyrosine-kinases (PTK) is poorly understood. These enzymes possess Walker A and B ATP-binding motifs, which are effectively required for their autophosphorylation whereas these motifs are usually found in ATP-binding proteins but not in eukaryotic protein-kinases.
Didier, Soulat, Jean-Michel, Jault, Christophe, Geourjon, Patrice, Gouet, Alain J, Cozzone, Christophe, Grangeasse   +5 more
openaire   +2 more sources

The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. [PDF]

PLoS Pathogens, 2013
While phosphotyrosine modification is an established regulatory mechanism in eukaryotes, it is less well characterized in bacteria due to low prevalence. To gain insight into the extent and biological importance of tyrosine phosphorylation in Escherichia
Anne-Marie Hansen, Raghothama Chaerkady, Jyoti Sharma, J Javier Díaz-Mejía, Nidhi Tyagi, Santosh Renuse, Harrys K C Jacob, Sneha M Pinto, Nandini A Sahasrabuddhe, Min-Sik Kim, Bernard Delanghe, Narayanaswamy Srinivasan, Andrew Emili, James B Kaper, Akhilesh Pandey   +14 more
doaj   +1 more source

Clinical Evaluation of the Efficacy and Safety of Co-Administration of Wuzhi Capsule and Tacrolimus in Adult Chinese Patients with Myasthenia Gravis

Neuropsychiatric Disease and Treatment, 2021
Yuyao Peng, Fei Jiang, Ran Zhou, Wanlin Jin, Yi Li, Weiwei Duan, Liqun Xu, Huan Yang Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of ChinaCorrespondence: Liqun Xu; Huan YangDepartment of ...
Peng Y, Jiang F, Zhou R, Jin W, Li Y, Duan W, Xu L, Yang H   +7 more
doaj  

Investigation of the Impact of CYP3A5 Polymorphism on Drug–Drug Interaction between Tacrolimus and Schisantherin A/Schisandrin A Based on Physiologically-Based Pharmacokinetic Modeling

Pharmaceuticals, 2021
Wuzhi capsule (WZC) is commonly prescribed with tacrolimus in China to ease drug-induced hepatotoxicity. Two abundant active ingredients, schisantherin A (STA) and schisandrin A (SIA) are known to inhibit CYP3A enzymes and increase tacrolimus’s exposure.
Qingfeng He, Fengjiao Bu, Hongyan Zhang, Qizhen Wang, Zhijia Tang, Jing Yuan, Hai-Shu Lin, Xiaoqiang Xiang   +7 more
doaj   +1 more source

Wza gene knockout decreases Acinetobacter baumannii virulence and affects Wzy-dependent capsular polysaccharide synthesis

Virulence, 2020
To investigate the virulence of capsular polysaccharide export protein (Wza) in carbapenem-resistant Acinetobacter baumannii and its effect on capsule formation.
Tianshui Niu, Lihua Guo, Qixia Luo, Kai Zhou, Wei Yu, Yunbo Chen, Chen Huang, Yonghong Xiao   +7 more
doaj   +1 more source

Structural comparison CapAB/Wzc. A

, 2013
– Global superimposition. The structure of CapA1B1 (in cyan) has been superimposed with the CapA1B2 phosphorylated monomer (in blue) (PDB ID 3BFV) as well as with a subunit of the non-phosphorylated Wzc(K540M) octamer (in magenta) (PDB ID 3LA6).
Magali Aumont-Nicaise (161478), Sylvie Nessler (271816), Virginie Gueguen-Chaignon (271798), Aurore Fleurie (469897), Julien Nourikyan (469896), Solange Moréra (5656639), Vanesa Olivares-Illana (35761), Emmanuelle Béchet (5656636), Jakub Gruszczyk (469895), Céline Freton (469898), Christophe Grangeasse (271397)   +10 more
core   +1 more source

wzc sequence alignment across 12 capsular types.

, 2013
wzc sequences of 17 strains (NTUH-K2044, DTS, Chedid, NTUH-K9534, Kauffmann E5051, VGH404, VGH484, NK245, VGH916, NTUH-KP13, NK8, 889/50, MGH 78578, NTUH-KP35, A1142, VGH698 and A1517) representing 12 capsular types (K1, K2, K5, K9, K10, K14, K20, K52 ...
Tzu-Lung Lin (123673), Meng-Chuan Wu (180675), Jin-Town Wang (123680), Yi-Jiun Pan (180680), Yen-Hua Chen (494789), Pei-Fang Hsieh (180668), Chun-Ru Hsu (440956)   +6 more
core   +1 more source

Synergistic effects of trace ZrC/Zr on the mechanical properties and microstructure of tungsten as plasma facing materials

Nuclear Materials and Energy, 2019
Pure W, and W–0.5wt%ZrC (WZC) and W–2.0wt%Zr–0.5wt%ZrC (WZZC) alloys are fabricated using vacuum hot pressure (VHP) method to investigate the effects of trace ZrC or Zr/ZrC on the mechanical properties and microstructure of tungsten.
T. Zhang, Y.K. Wang, Z.M. Xie, C.S. Liu, Q.F. Fang   +4 more
doaj   +1 more source