Results 21 to 30 of about 1,533 (168)

H-NS Regulates the Virulence of Klebsiella pneumoniae by Affecting Capsular Polysaccharide Chain Synthesis and Anchoring [PDF]

Microorganisms
H-NS (histone-like nucleoid-structuring protein) is a global regulator affecting diverse bacterial processes. This study aimed to elucidate the regulatory role of H-NS in the virulence of Klebsiella pneumoniae (K. pneumoniae), particularly in relation to
Yichi Zhang, Zeyong Zhong, Yanchun Gong, Yuhan Yang, Deyi Zhao, Lijiang Chen, Jianming Cao, Tieli Zhou, Jianzhong Ye   +8 more
doaj   +2 more sources

Periplasmic Protein-Protein Contacts in the Inner Membrane Protein Wzc Form a Tetrameric Complex Required for the Assembly ofEscherichia coliGroup 1 Capsules [PDF]

Journal of Biological Chemistry, 2005
The K antigenic capsular polysaccharide forms a structural layer, the capsule, on the surfaces of Escherichia coli cells. The capsule provides an important protective covering that helps protect encapsulated bacteria from host immune defenses.
Bradley R. Clarke, Chris Whitfield, Hulley, M, Konstantinos Beis, Robert C. Ford, Collins, R F, Martyn Hulley, James H. Naismith, Richard F. Collins, Clarke, B R, Whitfield, C, Ford, R C, Naismith, J H, Beis, K   +13 more
core   +3 more sources

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

Drug Resistance Updates, 2022
Aims: To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and gain insights into diverse evolution and biology of these strains. Methods: Whole genome
He, Jintao, Hu, Huangdu, Zhang, Jinyong, Yu, Yunsong, Chen, Qiong, Chen, Zhifu, Zhang, Wang, Leptihn, Sebastian, Zou, Quanming, Lan, Peng, Hua, Xiaoting, Xu, Qingye, Jianzhong, Fan, Shi, Qiucheng, Jiang, Yan, Loh, Belinda Wei-Ching   +15 more
core   +3 more sources

Quorum sensing gene abaI enhancing capsule production and pathogenicity of Acinetobacter baumannii [PDF]

Frontiers in Microbiology
IntroductionAcinetobacter baumannii (A. baumannii) is a Gram-negative coccobacillus that can cause a variety of infectious diseases. The Quorum Sensing (QS) system is a widespread mechanism regulating group behavior in bacteria, playing a crucial role in
Zhilang Qiu, Zhilang Qiu, Zhilang Qiu, Zhilang Qiu, Yu Zheng, Kexin Yuan, Peiling Zhao, Guanfeng Wu, Guanfeng Wu, Yang Zeng, Huijun Cao, Xuejun Zhao, Liang Hong, Liang Hong, Guo Guo, Fei Mo, Yuping Wang, Jian Peng, Jian Peng, Jian Peng, Jian Peng   +20 more
doaj   +2 more sources

Carbon source–dependent transcriptomic regulation and monosaccharide remodeling of exopolysaccharide biosynthesis in Pediococcus pceusentosa LL-07 [PDF]

BMC Microbiology
Background Exopolysaccharides (EPSs) produced by lactic acid bacteria (LAB) play important roles in industrial applications. The type of carbon source affects both the production and composition of EPSs.
Kuan Lu, Xueya Wang, Ying Zhou, Qiujin Zhu   +3 more
doaj   +2 more sources

Characterization of the wzc gene from Pantoea sp. strain PPE7 and its influence on extracellular polysaccharide production and virulence on Pleurotus eryngii

Microbiological Research, 2015
To characterize of the pathogenicity gene from the soft rot pathogen Pantoea sp. PPE7 in Pleurotus eryngii, we constructed over 10,000 kanamycin-resistant transposon mutants of Pantoea sp. strain PPE7 by transposon mutagenesis.
J S Ryu, Y H Lee, Jeongyeo Lee, Hyeran Kim, M K Kim   +4 more
core   +3 more sources

Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae [PDF]

Communications Biology
Phage therapy is a promising antibacterial strategy against the antibiotic resistance crisis. The evolved phage resistance could pose a big challenge to clinical phage therapy.
Yu Fu, Ming Yin, Li Cao, Yanjun Lu, Ying Li, Luhua Zhang   +5 more
doaj   +2 more sources

Genomic and Functional Characterization of Multidrug-Resistant E. coli: Insights into Resistome, Virulome, and Signaling Systems [PDF]

Antibiotics
Introduction: Genetic plasticity and adaptive camouflage in critical pathogens have contributed to the global surge in multidrug-resistant (MDR) infections, posing a serious threat to public health and therapeutic efficacy.
Vijaya Bharathi Srinivasan, Naveenraj Rajasekar, Karthikeyan Krishnan, Mahesh Kumar, Chankit Giri, Balvinder Singh, Govindan Rajamohan   +6 more
doaj   +2 more sources

Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae [PDF]

Emerging Microbes and Infections
Phages demonstrate remarkable promise as antimicrobial agents against antibiotic-resistant bacteria. However, the emergence of phage-resistant strains poses challenges to their effective application.
Ping Li, Wenjie Ma, Jun Cheng, Cuixing Zhan, Hongzhou Lu, Jiayin Shen, Xin Zhou   +6 more
doaj   +2 more sources

Genetic, virulence, and antimicrobial resistance characteristics associated with distinct morphotypes in ST11 carbapenem-resistant Klebsiella pneumoniae [PDF]

Virulence
ST11 is the most common lineage among carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in Asia. Diverse morphotypes resulting from genetic mutations are associated with significant differences in microbial characteristics among K.
Tao Chen, Yuan Wang, Xiaohui Chi, Luying Xiong, Ping Lu, Xueting Wang, Yunbo Chen, Qixia Luo, Ping Shen, Yonghong Xiao   +9 more
doaj   +2 more sources