Carbon source–dependent transcriptomic regulation and monosaccharide remodeling of exopolysaccharide biosynthesis in Pediococcus pceusentosa LL-07 [PDF]
BMC MicrobiologyBackground Exopolysaccharides (EPSs) produced by lactic acid bacteria (LAB) play important roles in industrial applications. The type of carbon source affects both the production and composition of EPSs.
Kuan Lu +3 more
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Genomic and Functional Characterization of Multidrug-Resistant E. coli: Insights into Resistome, Virulome, and Signaling Systems [PDF]
AntibioticsIntroduction: Genetic plasticity and adaptive camouflage in critical pathogens have contributed to the global surge in multidrug-resistant (MDR) infections, posing a serious threat to public health and therapeutic efficacy.
Vijaya Bharathi Srinivasan +6 more
doaj +2 more sources
Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae [PDF]
Communications BiologyPhage therapy is a promising antibacterial strategy against the antibiotic resistance crisis. The evolved phage resistance could pose a big challenge to clinical phage therapy.
Yu Fu +5 more
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Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae [PDF]
Emerging Microbes and InfectionsPhages demonstrate remarkable promise as antimicrobial agents against antibiotic-resistant bacteria. However, the emergence of phage-resistant strains poses challenges to their effective application.
Ping Li +6 more
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Evolutionary Origins and Virulence Determinants of ST25 Hypervirulent <i>Klebsiella pneumoniae</i> in Swine: Genomic Insights and Functional Validation. [PDF]
Transbound Emerg DisThe global spread of multidrug‐resistant hypervirulent Klebsiella pneumoniae (MDR‐HvKp), among which carbapenem‐resistant strains are of major concern, poses a severe threat to public health due to its high mortality rate and extremely limited treatment options.
Chen Z +15 more
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The pharmacokinetic study of tacrolimus and Wuzhi capsule in Chinese liver transplant patients
Frontiers in Pharmacology, 2022 Objectives: Wuzhi Capsule (WZC) is often administrated with tacrolimus in liver transplant patients to reduce the toxicity of tacrolimus and relieve the financial burden of patients. We aimed to investigate the interaction between Wuzhi Capsule (WZC) and
Jinlong Qu +7 more
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mSphere, 2023 Klebsiella pneumoniae is a hospital-associated pathogen primarily causing urinary tract infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the hypervirulent strains, causing invasive community-acquired infections, and the ...
Saroj Khadka +7 more
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Effects of Zn addition on microstructure and tensile properties of Mg–Y–Co alloy
Journal of Materials Research and Technology, 2022 Effects of Zn addition on microstructure and mechanical properties of the extruded Mg97.8Y1.4Co0.8 (at.%, WC) alloy were investigated at room temperature.
Guangli Bi +7 more
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Tyrosine phosphorylation of the UDP-glucose dehydrogenase of Escherichia coli is at the crossroads of colanic acid synthesis and polymyxin resistance. [PDF]
PLoS ONE, 2008 BACKGROUND:In recent years, an idiosyncratic new class of bacterial enzymes, named BY-kinases, has been shown to catalyze protein-tyrosine phosphorylation.
Soline Lacour +4 more
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Frontiers in Microbiology, 2023 Klebsiella pneumoniae is an opportunistic pathogen that mainly causes nosocomial infections and hospital-associated pneumonia in elderly and immunocompromised people. However, multidrug-resistant hypervirulent K.
Md Roushan Ali +6 more
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