Results 21 to 30 of about 1,497 (166)

Klebsiella pneumoniae sugar import suppresses hypermucoviscosity [PDF]

Translation
Saroj Khadka, Laura A. Mike
doaj   +5 more sources

Fumarate and nitrate reduction regulator (FNR) modulates hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through anaerobic adaptation

Virulence
Hypervirulent Klebsiella pneumoniae (hvKP), a pathogen responsible for severe invasive infections, exhibits a hypermucoviscosity (HMV) phenotype that is closely associated with its virulence. While fumarate and nitrate reduction regulator (FNR), a global
Pinjia Wang, Chengbin Xie, Yidan Xu
exaly   +5 more sources

Enhancement of capsular hypermucoviscosity in Klebsiella pneumoniae by Acanthamoeba.

PLoS Neglected Tropical Diseases, 2023
BackgroundAcanthamoeba and Klebsiella pneumoniae are both environmental commensals. Recently, clinical harm caused by hypermucoviscous K. pneumoniae has been observed.
Jian-Ming Huang, Ko-Chiang Sung, Wei-Chen Lin, Hong-Yue Lai, Yu-Jen Wang   +4 more
doaj   +3 more sources

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness.

PLOS Pathogens, 2021
Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype associated with hvKp characterized by copious capsule production and poor ...
Sara N Smith, Valerie S Forsyth, Andrew J Stark, Harry L T Mobley, Laura A Mike, Jay Vornhagen, Michael A Bachman   +6 more
core   +5 more sources

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity [PDF]

mBio, 2019
The polysaccharide capsule is an essential virulence factor for Klebsiella pneumoniae in both community-acquired hypervirulent strains as well as health care-associated classical strains that are posing significant challenges due to multidrug resistance.
Taryn A. Miner, Joshua D. Quinn, Daniel R. Frederick, Virginia L. Miller, Kimberly A. Walker, Dominika Trzilova, Christopher A. Broberg, Victoria E. Sepúlveda, Michelle Palacios   +8 more
core   +4 more sources

In vivo evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by Klebsiella pneumoniae sequence type 512 [PDF]

mSphere
Carbapenemase-producing Klebsiella pneumoniae represents a major public health issue globally. Isolates with resistance to the newest drugs, like ceftazidime/avibactam (CZA), are increasingly reported.
Raponi, Giammarco, Palamara, Anna Teresa, Marzuillo, Carolina, Capitani, Valerio, Polani, Riccardo, Carattoli, Alessandra, Ceccarelli, Giancarlo, Scribano, Daniela, De Francesco, Alice, Arcari, Gabriele, Ambrosi, Cecilia, Ceparano, Mariateresa, Villari, Paolo   +12 more
core   +4 more sources

The global genomic landscape of hypervirulent <i>Klebsiella pneumoniae</i> from 1932 to 2021. [PDF]

mLife
Abstract The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the Illumina platform (177 of them fully sequenced through PacBio platform), representing the most ...
Jiang X, Li S, Li C, Yin Z, Chen F, Hu L, Lu T, Liu X, Wang Y, Ma G, Wang X, Chen F, Zhou D.   +12 more
europepmc   +2 more sources

Clinical and molecular characteristics of Klebsiella pneumoniae ventilator-associated pneumonia in mainland China [PDF]

BMC Infectious Diseases, 2016
Background Klebsiella pneumoniae is a prominent nosocomial pathogen that accounts for up to 10 % of all hospital-acquired infections. It is a frequent cause of ventilator-associated pneumonia (VAP).
Si Guo, JingJing Xu, YanShuan Wei, JunHong Xu, Yi Li, Rui Xue   +5 more
doaj   +2 more sources

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +2 more sources

Synergy of Plant Essential Oils in Antibiotic Therapy to Combat Klebsiella pneumoniae Infections

Pharmaceuticals, 2023
Increased antibiotic resistance presents a health problem worldwide. The World Health Organization published a list of pathogens considered a priority for designing new treatments.
Mariana Romo-Castillo, Victor Andrés Flores-Bautista, Silvia Laura Guzmán-Gutiérrez, Ricardo Reyes-Chilpa, Mayra León-Santiago, Victor Manuel Luna-Pineda   +5 more
doaj   +2 more sources