Results 21 to 30 of about 1,559 (168)

A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

PLOS Pathogens
Klebsiella pneumoniae, an emerging multidrug-resistant pathogen, exhibits hypermucoviscosity (HMV) as a critical virulence trait mediated by its capsular polysaccharide (CPS). Recent discoveries have determined acetylation as a significant modification for CPS, although its impact on HMV and virulence was previously unknown.
Lijun Wang, Zhe Wang, Hua Zhang, Qian Jin, Shuaihua Fan, Yanni Liu, Xueting Huang, Jun Guo, Chao Cai, Jing-Ren Zhang, Hui Wu   +10 more
openaire   +4 more sources

Ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae accompanied hypermucoviscosity acquisition

BMC Microbiology
Background Antimicrobial resistance and bacterial hypermucoviscosity, associated with escalating production of capsules, constitute major challenges for the clinical management of Klebsiella pneumoniae (K. pneumoniae) infections.
Yingyi Guo, Jiong Wang, Likang Yao, Yijing Wang, Yan Zhang, Chuyue Zhuo, Xu Yang, Feifeng Li, Jiahui Li, Baomo Liu, Nanhao He, Jiakang Chen, Shunian Xiao, Zhiwei Lin, Chao Zhuo   +14 more
doaj   +3 more sources

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness

PLOS Pathogens, 2020
Hypervirulent K . pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype associated with hvKp characterized by copious capsule production and ...
Laura A. Mike, Andrew J. Stark, Valerie S. Forsyth, Jay Vornhagen, Sara N. Smith, Michael A. Bachman, Harry L.T. Mobley   +6 more
openaire   +5 more sources

In vivo evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by Klebsiella pneumoniae sequence type 512 [PDF]

mSphere
ABSTRACT Carbapenemase-producing Klebsiella pneumoniae represents a major public health issue globally. Isolates with resistance to the newest drugs, like ceftazidime/avibactam (CZA), are increasingly reported.
Capitani, Valerio, Arcari, Gabriele, Ambrosi, Cecilia, Scribano, Daniela, Ceparano, Mariateresa, Polani, Riccardo, De Francesco, Alice, Raponi, Giammarco, Ceccarelli, Giancarlo, Villari, Paolo, Palamara, Anna Teresa, Marzuillo, Carolina, Carattoli, Alessandra   +12 more
openaire   +4 more sources

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity [PDF]

mBio, 2019
Klebsiella pneumoniae continues to be a substantial public health threat due to its ability to cause health care-associated and community-acquired infections combined with its ability to acquire antibiotic resistance. Novel therapeutics are needed to combat this pathogen, and a greater understanding of its virulence factors is ...
Kimberly A. Walker, Taryn A. Miner, Michelle Palacios, Dominika Trzilova, Daniel R. Frederick, Christopher A. Broberg, Victoria E. Sepúlveda, Joshua D. Quinn, Virginia L. Miller   +8 more
openaire   +4 more sources

Clinical and molecular characteristics of Klebsiella pneumoniae ventilator-associated pneumonia in mainland China [PDF]

BMC Infectious Diseases, 2016
Background Klebsiella pneumoniae is a prominent nosocomial pathogen that accounts for up to 10 % of all hospital-acquired infections. It is a frequent cause of ventilator-associated pneumonia (VAP).
Si Guo, JingJing Xu, YanShuan Wei, JunHong Xu, Yi Li, Rui Xue   +5 more
doaj   +2 more sources

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +2 more sources

Synergy of Plant Essential Oils in Antibiotic Therapy to Combat Klebsiella pneumoniae Infections

Pharmaceuticals, 2023
Increased antibiotic resistance presents a health problem worldwide. The World Health Organization published a list of pathogens considered a priority for designing new treatments.
Mariana Romo-Castillo, Victor Andrés Flores-Bautista, Silvia Laura Guzmán-Gutiérrez, Ricardo Reyes-Chilpa, Mayra León-Santiago, Victor Manuel Luna-Pineda   +5 more
doaj   +2 more sources

Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits

Nature Communications, 2022
Phenotypic and genotypic evolution in worrisome Klebsiella spp. is influenced by the capsule. Here the authors show that adaptation outside the host can impact virulence-associated traits, including de novo emergence of hypermucoviscosity.
Amandine Nucci, Eduardo P. C. Rocha, Olaya Rendueles   +2 more
doaj   +2 more sources

Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics [PDF]

Scientific Reports, 2023
Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were characterized ...
Bernd Neumann, Claudia Stürhof, Anca Rath, Bärbel Kieninger, Elias Eger, Justus U. Müller, Alexander von Poblocki, Nadja Gerlitz, Paul Wollschläger, Wulf Schneider-Brachert, Katharina Schaufler, Kathleen Klaper, Jörg Steinmann   +12 more
doaj   +2 more sources