Results 41 to 50 of about 1,559 (168)

Hypermucoviscosity as a Virulence Factor in ExperimentalKlebsiella pneumoniaeEndophthalmitis [PDF]

Investigative Opthalmology & Visual Science, 2008
Klebsiella pneumoniae is a common cause of endogenous bacterial endophthalmitis, a disease that frequently results in a poor visual outcome. Hypermucoviscosity has been identified as a virulence factor among clinical bacteremia isolates of K. pneumoniae. In this study, an experimental murine model of K.
Brandt J, Wiskur, Jonathan J, Hunt, Michelle C, Callegan   +2 more
openaire   +2 more sources

Hypervirulence and hypermucoviscosity: Two different but complementaryKlebsiellaspp. phenotypes? [PDF]

Virulence, 2017
Since the hypermucoviscous variants of Klebsiella pneumoniae were first reported, many cases of primary liver abscesses and other invasive infections caused by this pathogen have been described worldwide. Hypermucoviscosity is a phenotypic feature characterized by the formation of a viscous filament ≥5 mm when a bacterial colony is stretched by a ...
Juan Carlos, Catalán-Nájera, Ulises, Garza-Ramos, Humberto, Barrios-Camacho   +2 more
openaire   +2 more sources

Anti-Biofilm and Associated Anti-Virulence Activities of Selected Phytochemical Compounds against Klebsiella pneumoniae

Plants, 2022
The ability of Klebsiella pneumoniae to form biofilm renders the pathogen recalcitrant to various antibiotics. The difficulty in managing K. pneumoniae related chronic infections is due to its biofilm-forming ability and associated virulence factors ...
Idowu J. Adeosun, Itumeleng T. Baloyi, Sekelwa Cosa   +2 more
doaj   +1 more source

Genes enhancing bacteremia are largely dispensable for in vitro replication and have differential effects on hypermucoviscosity.

, 2023
(A) K. pneumoniae strains with transposon mutations in genes influencing bacteremia were grown in LB and the OD600 was measured every 15 minutes for 12 hours. (B) Hypermucoviscosity was measured for each strain; hypermucoviscosity = (post-spin)/(pre-spin)
Sophia Mason (10731844), Lavinia V. Unverdorben (16612296), Michael A. Bachman (7310243), Harry L. T. Mobley (7310240), Weisheng Wu (4110202), Sara N. Smith (10305756), Lili Zhao (442802), Valerie Forsyth (7310237), Caitlyn L. Holmes (6743807), Bridget S. Moricz (8382030), Alexis E. Wilcox (16612293)   +10 more
core   +1 more source

The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae

Current Opinion in Microbiology, 2020
For ∼30 years, two distinct groups of clinical isolates of Klebsiella pneumoniae have been recognized. Classical strains (cKp) are typically isolated from patients with some degree of immunocompromise and are not virulent in mouse models of infection whereas hypervirulent strains (hvKp) are associated with community acquired invasive infections and are
Kimberly A, Walker, Virginia L, Miller
openaire   +3 more sources

Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant [PDF]

Microbiologyopen
Genotypic characterization of 82 clinical K. pneumoniae isolates identified 34 hypervirulent strains. The peg‐344 most strongly associated with hypervirulence (p = 0.0001) but with only 58.8% sensitivity and no signal in over 40% of hvKP isolates, it's a confirmatory marker, not a standalone diagnostic. ABSTRACT Klebsiella pneumoniae is an increasingly
Elkady F, Basher N, Abdulrahman M, Hashem A, Metwally R, Tawab A, Saied E, Ibrahim N, Aufy M.   +8 more
europepmc   +2 more sources

Classical and hypervirulent K. pneumoniae capsule and hypermucoviscosity phenotypes.

, 2023
(A) Capsule quantification using a glucuronic acid assay comparing hvKp 43816), cKp KR174, and their respective capsule (cps) and O antigen (wecA) knockouts. The dotted line represents the limit of detection for uronic acid.
Cory J. Knoot (1907764), Lloyd S. Robinson (9299759), David A. Rosen (6313433), Nichollas E. Scot (15419346), Christian M. Harding (11547775), Evgeny Vinogradov (159941), Paeton L. Wantuch (1667614)   +6 more
core   +1 more source

A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition [PDF]

, 2020
Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, and pneumonia, driven mainly by the emergence of successful high-risk clonal lineages.
Balau, Veronika, Eckmanns, Tim, Hübner, Nils-Olaf, Schaefer, Stephan, Schaufler, Katharina, Bohnert, Jürgen A., Gierer, Wolfgang, Guenther, Sebastian, Becker, Karsten, Eger, Elias, Heiden, Stefan E., Gatermann, Sören, Heidecke, Claus-Dieter, Kramer, Axel, Veronika Balau, Sebastian Guenther, Sören Gatermann, Claus-Dieter Heidecke, Stephan Schaefer, Katharina Schaufler, Tim Eckmanns, Jürgen A. Bohnert, Wolfgang Gierer, Axel Kramer, Karsten Becker, Elias Eger, Stefan E. Heiden, Nils-Olaf Hübner   +27 more
core   +1 more source

Capsular Serotyping and Antimicrobial Drug Resistance of Klebsiella pneumoniae Strains Isolated from a Tertiary Care Hospital, Southern India [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: The rapid spread of Hypervirulent Klebsiella pneumoniae (hvKP) and Multi Drug Resistant (MDR) strains among the clinical isolates of K.pneumoniae is a great deal of concern.
LATHAMANI KOTEKANI, SUBBANNAYYA KOTIGADDE, BHASKARAN THULICHERI NAIR   +2 more
doaj   +1 more source

Sialic acid involved in hypermucoviscosity phenotype ofKlebsiella pneumoniaeand associated with resistance to neutrophil phagocytosis [PDF]

Virulence, 2014
Klebsiella pneumoniae (KP) with the hypermucoviscosity (HV) phenotype has abundant capsular polysaccharides (CPS) and usually causes an invasive syndrome. Sialic acid (Sia), a component of CPS in KP strains with the HV phenotype, may be anti-phagocytic.
Chen-Hsiang, Lee, Chia-Chi, Chang, Jien-Wei, Liu, Rong-Fu, Chen, Kuender D, Yang   +4 more
openaire   +2 more sources