Results 241 to 250 of about 334,421 (299)
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Advanced Healthcare Materials, EarlyView.Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
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Escape from X inactivation is directly modulated by levels of Xist non-coding RNA
Hauth A +17 more
europepmc +1 more source
Author response: Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2
, 2019 Marissa Cloutier +7 more
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Advanced Healthcare Materials, EarlyView.Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral +8 more
wiley +1 more source
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Advanced Healthcare Materials, EarlyView.This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source
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Current Opinion in Genetics & Development, 2007
Random inactivation of one of the two female X chromosomes establishes dosage compensation between XY males and XX females in placental mammals. X inactivation is controlled by the X inactivation center (Xic). Recent advances in genome sequencing show that the Xic has evolved from an ancestral vertebrate gene cluster in placental mammals and has ...
Wutz, A, Gribnau, Joost
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Random inactivation of one of the two female X chromosomes establishes dosage compensation between XY males and XX females in placental mammals. X inactivation is controlled by the X inactivation center (Xic). Recent advances in genome sequencing show that the Xic has evolved from an ancestral vertebrate gene cluster in placental mammals and has ...
Wutz, A, Gribnau, Joost
openaire +2 more sources
Cytogenetic and Genome Research, 2002
Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off.
C M, Disteche +2 more
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Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off.
C M, Disteche +2 more
openaire +2 more sources
Seminars in Cell & Developmental Biology, 2010
X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA.
Ruben, Agrelo, Anton, Wutz
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X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA.
Ruben, Agrelo, Anton, Wutz
openaire +2 more sources
Science, 2000
Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, [Clerc and Avner][1] describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei ([ Eggan et al. ][2]) that reveal how the inactivation state of
Philippe Clerc, Philip Avner
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Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, [Clerc and Avner][1] describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei ([ Eggan et al. ][2]) that reveal how the inactivation state of
Philippe Clerc, Philip Avner
openaire +1 more source