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X inactivation, differentiation, and DNA methylation
Cytogenetic and Genome Research, 1975A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation. A key feature of the model is the proposal of sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate ...
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Skewed X Inactivation and Recurrent Spontaneous Abortion
Seminars in Reproductive Medicine, 2001Recent studies show that women experiencing recurrent spontaneous abortion exhibit nonrandom X-chromosome inactivation (XCI) more often than in controls. This suggests that genetic factors may be important in explaining the losses in this subset of women. Nonetheless there are a number of possible explanations for this finding and the underlying causes
W P, Robinson +3 more
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Genetics. Reprogramming X inactivation.
Science (New York, N.Y.), 2000Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, Clerc and Avner describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei (Eggan et al.) that reveal how the inactivation state of the X ...
P, Clerc, P, Avner
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Heterochromatin and X Inactivation
2007Cytological examinations of nuclear structure in the early 1900s led to the discovery of heterochromatic regions that retain the deeply staining properties of metaphase chromatin throughout the cell cycle. The molecular determinants of heterochromatin have largely remained a mystery.
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The role of Xist in X-inactivation
Current Opinion in Genetics & Development, 1998The past year has seen important progress in our understanding of the role of the X inactive specific transcript gene (Xist) in the initiation and propagation of X-inactivation. A 35 kb Xist transgene had been shown to recapitulate the functions of the X-inactivation centre, progress has been made towards indentifying factors controlling the randomness
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Gene regulation in time and space during X-chromosome inactivation
Nature Reviews Molecular Cell Biology, 2022Agnese Loda +2 more
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