Results 31 to 40 of about 332,161 (328)

DNA loci cross-talk through thermodynamics [PDF]

, 2009
The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms.
Nicodemi, Mario, Scialdone, Antonio
core   +6 more sources

Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]

PLoS ONE, 2009
Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar, Vivek Thakur, Ramakrishna Ramaswamy, Deepti Deobagkar   +3 more
doaj   +1 more source

The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. [PDF]

, 2014
BackgroundX chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions in somatic cells.
Bonora, Giancarlo, Minkovsky, Alissa, Patel, Sanjeet, Plath, Kathrin, Rankin-Gee, Elyse, Sahakyan, Anna   +5 more
core   +3 more sources

Genes that escape from X inactivation [PDF]

Human Genetics, 2011
To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3 ...
Joel B, Berletch, Fan, Yang, Jun, Xu, Laura, Carrel, Christine M, Disteche   +4 more
openaire   +2 more sources

Rlim/Rnf12, Rex1, and X Chromosome Inactivation

Frontiers in Cell and Developmental Biology, 2019
RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
doaj   +1 more source

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females [PDF]

, 2013
The maintenance of key germline derived DNA methylation patterns during preimplantation development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided by the oocyte.
A Wagschal, AL Fowden, AS Doherty, B Lehnertz, BK Sun, C Beard, C Mertineit, Christoph Plass, Christopher C. Oakes, CM Disteche, CP Walsh, CY Howell, D Bourc'his, DE Cohen, DJ Smiraglia, E Borowczyk, E Heard, EJ Michaud, H Barr, I Hatada, I Okamoto, I Zvetkova, J Chaumeil, J Silva, J. Richard Chaillet, JA Bailey, Jacquetta M. Trasler, JC Chow, JD West, Jeannie T. Lee, JM Trasler, Josée Martel, JT Lee, JT Lee, K Hata, KD Huynh, KD Huynh, KL Tucker, KP Himes, L Yu, LL Carlson, M Ehrich, M Hemberger, M Kaneda, M Toppings, M. Cecilia Cirio, Marisa S. Bartolomei, MC Cardoso, MC Cirio, MC Cirio, MF Lyon, N Stavropoulos, N Takagi, Pauline de Zeeuw, RJ Klose, RM Boumil, S Ratnam, Serge McGraw, SH Namekawa, T Ohhata, T Ohhata, T Sado, T Sado, T Sado, T Sado, TH Bestor, W Mak, W Mak, W Reik, W Reik, WA Schulz, Winifred Mak, Y Kurihara, Y Marahrens, Y Ogawa, Y Okazaki   +75 more
core   +4 more sources

Muscular dystrophy associated with the DMD gene in women

Нервно-мышечные болезни
Dystrophinopathies are a spectrum of X-linked muscular disorders associated with pathogenic/likely pathogenic variants in the dystrophin gene (DMD). Typically, the condition develops in males, but cases of symptom manifestation have also been described ...
E. O. Vorontsova, A. V. Zinina, O. A. Shchagina   +2 more
doaj   +1 more source

Elastic dosage compensation by X-chromosome upregulation

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
doaj   +1 more source

A Comparative Analysis of Mouse Imprinted and Random X-Chromosome Inactivation

Epigenomes
The mammalian sexes are distinguished by the X and Y chromosomes. Whereas males harbor one X and one Y chromosome, females harbor two X chromosomes.
Rebecca M. Malcore, Sundeep Kalantry
doaj   +1 more source

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]

PLoS Genetics, 2008
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston, Frances L Lovell, Daniel A Leongamornlert, Barbara E Stranger, Emmanouil T Dermitzakis, Mark T Ross   +5 more
doaj   +1 more source