Results 131 to 140 of about 7,623,875 (163)

Phenomenology of “Lubag” or X-Linked Dystonia–Parkinsonism [PDF]

Movement Disorders, 2002
AbstractX‐linked dystonia–parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay. We present cinematographic material of 11 cases of Lubag carrying the XDP haplotypes who manifest with a wide spectrum of movement ...
Andrew Singleton, John Anthony Hardy, Virgilio Gerald H Evidente   +2 more
exaly   +12 more sources

Differential Response of Dystonia and Parkinsonism Following Globus Pallidus Internus Deep Brain Stimulation in X-Linked Dystonia-Parkinsonism (Lubag)

Stereotactic and Functional Neurosurgery, 2010
<i>Background:</i> X-linked dystonia-parkinsonism (XDP; DYT3; Lubag) is an adult-onset hereditary progressive dystonia/parkinsonism which is typically minimally responsive to pharmacological treatment.
Nelson H Hwynn, Irene A Malaty, Genko Oyama   +2 more
exaly   +2 more sources

Long-Term Outcomes of Bilateral Pallidal Deep Brain Stimulation for X-Linked Dystonia and Parkinsonism

Stereotactic and Functional Neurosurgery, 2018
BACKGROUND: X-linked dystonia parkinsonism (XDP) causes adult-onset progressive dystonia and parkinsonism, which may not respond to pharmacotherapy. OBJECTIVE: Previous case reports have reported beneficial effects from bilateral pallidal (GPi) deep ...
Camilla Kilbane, Philip A Starr, Susan Heath   +2 more
exaly   +2 more sources

Basal Ganglia and Cerebellar Pathology in X-Linked Dystonia-Parkinsonism [PDF]

Brain, 2018
X-linked dystonia-parkinsonism is a neurodegenerative movement disorder characterized by adult-onset dystonia combined with parkinsonism over the disease course. Previous imaging and pathological findings indicate exclusive striatal atrophy with predominant pathology of the striosomal compartment in the dystonic phase of X-linked dystonia-parkinsonism.
Roland Dominic Jamora, Norbert Brüggemann, Raymond L Rosales   +2 more
exaly   +3 more sources

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A Network Imaging Biomarker of X‐Linked Dystonia‐Parkinsonism

Annals of Neurology, 2023
Objective The purpose of this study was to characterize a metabolic brain network associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed Filipino men with XDP (age = 44.4 ± 8.5 years ...
Martin Niethammer, Chris C. Tang, Roland Dominic G. Jamora, An Vo, Nha Nguyen, Yilong Ma, Shichun Peng, Jeff L. Waugh, Ana Westenberger, David Eidelberg   +9 more
openaire   +2 more sources

X-linked dystonia Parkinsonism: crossing a new threshold

Journal of Neural Transmission, 2021
X-linked dystonia parkinsonism (XDP) is a neurodegenerative disorder that has received significant interest on several fronts. Although much still remains to be elucidated regarding the disease cause, a robust amount of data has been produced in recent years compared to when it was first described in 1976.
Arlene R. Ng, Roland Dominic G. Jamora, Raymond L. Rosales   +2 more
openaire   +2 more sources

Neurocognitive profile of patients with X-linked dystonia-parkinsonism

Journal of Neural Transmission, 2021
X-linked dystonia-parkinsonism (XDP) is a debilitating movement disorder endemic to the Panay Island, Philippines. Most studies focus on motor symptoms, hence we reviewed the neurocognitive profile of XDP patients. Neurocognitive testing of XDP patients focused on five domains: general intellectual functioning, episodic memory, language, attention and ...
Roland Dominic G. Jamora, Cezar Thomas R. Suratos, Jesi Ellen C. Bautista, Gail Melissa I. Ramiro, Ana Westenberger, Christine Klein, Lourdes K. Ledesma   +6 more
openaire   +2 more sources

Speech and swallowing deficits in X-Linked Dystonia-Parkinsonism

Parkinsonism & Related Disorders, 2021
X-linked Dystonia-Parkinsonism (XDP) is a progressive, disabling disease characterized by the devastating impairment of bulbar function, including speech and swallowing. Despite these detrimental impacts, bulbar impairments in this population are not well characterized.To identify impairments in the bulbar system measured by oromotor performance in ...
Ana Luiza Zaninotto, Jan K. de Guzman, Kaila L. Stipancic, Bridget J. Perry, Melanie L. Supnet, Criscely Go, Nutan Sharma, Jordan R. Green   +7 more
openaire   +2 more sources

The Promise of Deep Brain Stimulation in X-Linked Dystonia Parkinsonism

International Journal of Neuroscience, 2011
X-Linked dystonia parkinsonism (XDP) is a rapidly progressive and disabling neurodegenerative disease affecting mainly male Filipinos with origins from Panay Island. We reviewed all the past neurosurgical ablative procedures done for XDP patients listed in the Philippine XDP registry.
Roland Dominic Jamora, Raymond L Rosales, Theodor S Vesagas   +2 more
exaly   +3 more sources

Voice and swallowing dysfunction in X‐linked dystonia parkinsonism

The Laryngoscope, 2019
ObjectivesTo systematically characterize and describe voice and swallowing manifestations in patients with X‐linked dystonia parkinsonism (XDP) and correlate with quality‐of‐life (QOL) measures.MethodsThirty‐four patients with XDP with communication and swallowing difficulties underwent neurological examination, head and neck examination ...
Phillip C. Song, Hoai Le, Patrick Acuna, Jan Kristopher Palentinos De Guzman, Nutan Sharma, Taylor N. Francouer, Marisela E. Dy, Criscely L. Go   +7 more
openaire   +2 more sources