Results 1 to 10 of about 196,851 (322)

Mechanisms of Choice in X-Chromosome Inactivation

Cells, 2022
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate.
Giulia Furlan, Rafael Galupa
doaj   +4 more sources

Identification of skewed X chromosome inactivation using exome and transcriptome sequencing in patients with suspected rare genetic disease [PDF]

BMC Genomics
Background X-chromosome inactivation (XCI) is an epigenetic process that occurs during early development in mammalian females by randomly silencing one of two copies of the X chromosome in each cell.
Numrah Fadra, Laura E Schultz-Rogers, Pritha Chanana, Margot A Cousin, Erica L Macke, Alejandro Ferrer, Filippo Pinto e Vairo, Rory J Olson, Gavin R Oliver, Lindsay A Mulvihill, Garrett Jenkinson, Eric W Klee   +11 more
doaj   +4 more sources

X-Chromosome Inactivation and Related Diseases

Genetics Research, 2022
X-chromosome inactivation (XCI) is the form of dosage compensation in mammalian female cells to balance X-linked gene expression levels of the two sexes.
Zhuo Sun, Jinbo Fan, Yang Wang
doaj   +2 more sources

Altered X-chromosome inactivation predisposes to autoimmunity. [PDF]

Sci Adv
In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases while females are more susceptible to systemic autoimmunity.
Huret C, Ferrayé L, David A, Mohamed M, Valentin N, Charlotte F, Savignac M, Goodhardt M, Guéry JC, Rougeulle C, Morey C.   +10 more
europepmc   +2 more sources

Population variability in X-chromosome inactivation across 10 mammalian species [PDF]

Nature Communications
One of the two X-chromosomes in female mammals is epigenetically silenced in embryonic stem cells by X-chromosome inactivation. This creates a mosaic of cells expressing either the maternal or the paternal X allele.
Jonathan M. Werner, John Hover, Jesse Gillis   +2 more
doaj   +2 more sources

A Comparative Analysis of Mouse Imprinted and Random X-Chromosome Inactivation [PDF]

Epigenomes
The mammalian sexes are distinguished by the X and Y chromosomes. Whereas males harbor one X and one Y chromosome, females harbor two X chromosomes.
Rebecca M. Malcore, Sundeep Kalantry
doaj   +2 more sources

X chromosome inactivation during Drosophila spermatogenesis. [PDF]

PLoS Biology, 2007
Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to ...
Winfried Hense, John F Baines, John Parsch   +2 more
doaj   +6 more sources

IndiSPENsable for X Chromosome Inactivation and Gene Silencing [PDF]

Epigenomes, 2023
For about 30 years, SPEN has been the subject of research in many different fields due to its variety of functions and its conservation throughout a wide spectrum of species, like worms, arthropods, and vertebrates.
Corinne Kaufmann, Anton Wutz
doaj   +2 more sources

An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation [PDF]

Frontiers in Genetics
ObjectivesHemophilia A (HA) is an X-linked recessive inherited bleeding disorder that typically affects men. Women are usually asymptomatic carriers, and rarely presenting with severe or moderately severe phenotype.
Xiaoyan Tan, Yi Yang, Xia Wu, Jing Zhu, Teng Wang, Huihui Jiang, Shu Chen, Shifeng Lou   +7 more
doaj   +2 more sources

Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape [PDF]

Nature Communications, 2018
The mammalian inactive X-chromosome (Xi) is structurally distinct from all other chromosomes and serves as a model for how the 3D genome is organized. The Xi shows weakened topologically associated domains and is instead organized into megadomains and ...
John E. Froberg, Stefan F. Pinter, Andrea J. Kriz, Teddy Jégu, Jeannie T. Lee   +4 more
openalex   +2 more sources