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Xanthine urolithiasis: Inhibitors of xanthine crystallization [PDF]
PLOS ONE, 2018 AbstractOBJECTIVETo identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria.METHODSThe formation of xanthine crystals in synthetic urine and the effects of 10 potential crystallization ...
Grases, Felix +3 more
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Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]
AGE, 1997 Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
Hae Young Chung +7 more
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Xanthine oxidoreductase and xanthine oxidase in human cornea.
Histology and histopathology, 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J. +3 more
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Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium [PDF]
Biochemical and Biophysical Research Communications, 1986 We directly measured the activity of the enzymes xanthine oxidase and xanthine dehydrogenase in rabbit and rat hearts, using a sensitive radiochemical assay. Neither xanthine oxidase activity nor xanthine dehydrogenase activity was detected in the rabbit heart.
Grum, Cyril M. +3 more
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The Role of Xanthine Oxidase and Xanthine Dehydrogenase in Skin Ischemia [PDF]
Journal of Surgical Research, 1994 The importance of sequential events which lead to skin necrosis has significant implications in trauma, vascular injury, and wound healing. In this series of experiments, we tested the hypothesis that xanthine oxidase (XO) activity was increased along an ischemic gradient of a skin flap and that the XO enzyme activity correlated with an increase in ...
Rees, Riley S. +6 more
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The action of xanthin and methyl xanthins on the isolated intestine
Experimental Biology and Medicine, 1916 The tests were made with different concentrations of xanthin and its derivatives dissolved in Locke's solution which were carried out on segments of different parts of the intestine of the rabbit. Sodium xanthin in concentrations of 1 : 2,000 and 1 : 1,000 caused increased tonus which was more pronounced in the large than in the small intestine.
William Salant, E. W. Schwartze
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The Mechanism of Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
, 1998 Xanthine dehydrogenase and xanthine oxidase are complex metalloflavoproteins that represent alternate forms of the same gene product. The cDNAs encoding the enzymes have been cloned from several sources, and structural information is becoming available.
Tomoko Nishino +4 more
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Quinone-Enhanced Reduction of Nitric Oxide by Xanthine/Xanthine Oxidase [PDF]
Chemical Research in Toxicology, 2009 The quinones 1,4-naphthoquinone, methyl-1,4-naphthoquinone, tetramethyl-1,4-benzoquinone, 2,3-dimethoxy-5-methyl-1,4-benzoquinone, 2,6-dimethylbenzoquinone, 2,6-dimethoxybenzoquinone, and 9,10-phenanthraquinone enhance the rate of nitric oxide reduction by xanthine/xanthine oxidase in nitrogen-saturated phosphate buffer (pH 7.4).
Antonio E. Alegria, Pedro Sanchez-Cruz
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2010 Hereditary xanthinuria type I, a defect of purine metabolism, results from a genetic deficiency of xanthine oxidase. It is an uncommon cause of stone formation in children. We report here two children with xanthine urolithiasis. The first patient was an 8-year-old boy who presented with repeated episodes of hematuria evaluated with excretory urography,
Gargah Tahar +4 more
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