Results 1 to 10 of about 112,529 (303)

Quantitative Structure–Neurotoxicity Assessment and In Vitro Evaluation of Neuroprotective and MAO-B Inhibitory Activities of Series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides

Molecules, 2022
The neurotoxic, neuroprotective and MAO-B inhibitory effects of series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides are evaluated.
Magdalena Kondeva-Burdina, Javor Mitkov, Iva Valkova, Lily Peikova, Maya Georgieva, Alexander Zlatkov   +5 more
doaj   +1 more source

High Performance Liquid Chromatography Analysis and Description of Purine Content of Diets Suitable for Dogs with Leishmania Infection during Allopurinol Treatment—A Pilot Trial

Animals, 2023
Reducing the alimentary purine intake contributes to the prevention of purine (especially xanthine) urolith formation, a common adverse effect of allopurinol treatment in dogs with Leishmania infections. Analyses of the purine content are not required in
Melanie Kaempfle, Michèle Bergmann, Petra Koelle, Katrin Hartmann   +3 more
doaj   +1 more source

Label-Free ZnIn₂S₄/UiO-66-NH₂ Modified Glassy Carbon Electrode for Electrochemically Assessing Fish Freshness by Monitoring Xanthine and Hypoxanthine

Chemosensors, 2022
Considering that simultaneous detection of xanthine (XA) and hypoxanthine (HXA) has been proved to be a reliable and feasible method for assessing fish freshness, a novel electrochemical sensing platform based on the ZnIn2S4/UiO-66-NH2 modified glassy ...
Debin Song, Qiaowei Chen, Chunyang Zhai, Hengcong Tao, Lina Zhang, Tianbo Jia, Zhiwang Lu, Wuyang Sun, Pengxiang Yuan, Baikang Zhu   +9 more
doaj   +1 more source

Alleviation of Hyperuricemia by Strictinin in AML12 Mouse Hepatocytes Treated with Xanthine and in Mice Treated with Potassium Oxonate

Biology, 2023
Hyperuricemia, an abnormally high level of blood uric acid, is a major risk factor for gout. Although xanthine oxidase inhibitors were clinically used to lower blood uric acid level, the concerned side effects restricted their utilization. In this study,
Kuo-Ching Huang, Yu-Ting Chang, Rosita Pranata, Yung-Hsuan Cheng, Yu-Chi Chen, Ping-Chung Kuo, Yi-Hsuan Huang, Jason T. C. Tzen, Rong-Jane Chen   +8 more
doaj   +1 more source

Integration of Non-Targeted Metabolomics and Targeted Quantitative Analysis to Elucidate the Synergistic Antidepressant Effect of Bupleurum Chinense DC-Paeonia Lactiflora Pall Herb Pair by Regulating Purine Metabolism

Frontiers in Pharmacology, 2022
Graphical ...
Jiajun Chen, Jiajun Chen, Jiajun Chen, Tian Li, Tian Li, Tian Li, Xuemei Qin, Xuemei Qin, Xuemei Qin, Guanhua Du, Guanhua Du, Yuzhi Zhou, Yuzhi Zhou, Yuzhi Zhou   +13 more
doaj   +1 more source

The synthesis, characterization and biological evaluation of a new nitric oxide donor agent [PDF]

Journal of the Serbian Chemical Society, 2014
The synthesis of a new xanthine nitric oxide donor (TSP-81) has been discussed. The designed compound includes two structural moieties - theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide) linked by the nitric oxide ...
Profire Lenuta, Apotrosoaei Maria, Oprea Anca, Brebu Mihai, Lupascu Florentina, Lupusoru Elena Catalina, Vasile Cornelia   +6 more
doaj   +1 more source

Efficient and Practical Radiosynthesis of Novel [131I]-Xanthine and [131I]-Hypoxanthine

Atom Indonesia, 2022
Natural products (NPs) have been the basis for the discovery and development of pharmacologically relevant drug-related molecules, including radiopharmaceuticals.
H. Wongso, W. Nuraeni, E. Rosyidiah
doaj   +1 more source

A Newly Developed Method-Based Xanthine Oxidoreductase Activities in Various Human Liver Diseases

Biomedicines, 2023
Studies evaluating xanthine oxidoreductase (XOR) activities in comprehensive liver diseases are scarce, and different etiologies have previously been combined in groups for comparison.
Ken Sato, Atsushi Naganuma, Tamon Nagashima, Yosuke Arai, Yuka Mikami, Yuka Nakajima, Yuki Kanayama, Tatsuma Murakami, Sanae Uehara, Daisuke Uehara, Yuichi Yamazaki, Takayo Murase, Takashi Nakamura, Toshio Uraoka   +13 more
doaj   +1 more source

Efficient Oxidase Biosensors Based on Bioelectrocatalytic Surfaces of Electrodeposited Ferrocenyl Polycyclosiloxanes—Pt Nanoparticles

Chemosensors, 2021
The in-situ synthesis of catalytic surfaces with metallic nanoparticles must overcome the issues related to particle aggregation and polydispersity in the particle size.
Alvaro Boluda, Carmen M. Casado, Beatriz Alonso, M. Pilar García Armada   +3 more
doaj   +1 more source

Postmortem Alteration of Purine Metabolism in Coronary Artery Disease

Metabolites, 2023
A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding
Phakchira Somtua, Churdsak Jaikang, Giatgong Konguthaithip, Kanicnan Intui, Somlada Watcharakhom, Timothy E. O’Brien, Yutti Amornlertwatana   +6 more
doaj   +1 more source