Results 1 to 10 of about 147,306 (350)
The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors
Oxidative Medicine and Cellular Longevity, 2021 Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA).
Ning Liu, Youzhi Xu, Wenjie Lu
exaly +2 more sources
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Nature Communications, 2015 Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
Annette Ives +2 more
exaly +2 more sources
Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Redox Biology, 2021 Massimo Bortolotti +2 more
exaly +2 more sources
Biology, 2023 Hyperuricemia, an abnormally high level of blood uric acid, is a major risk factor for gout. Although xanthine oxidase inhibitors were clinically used to lower blood uric acid level, the concerned side effects restricted their utilization. In this study,
Kuo-Ching Huang +8 more
doaj +1 more source
Animals, 2023 Reducing the alimentary purine intake contributes to the prevention of purine (especially xanthine) urolith formation, a common adverse effect of allopurinol treatment in dogs with Leishmania infections. Analyses of the purine content are not required in
Melanie Kaempfle +3 more
doaj +1 more source
Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease
Scientific Reports, 2021 As previous studies have reported finding an association between hyperuricemia and the development of cardiovascular and chronic kidney disease, hyperuricemia is thought to be an independent risk factor for hypertension and diabetic mellitus. However, we
Hirotaka Saito +10 more
semanticscholar +1 more source
Chemosensors, 2022 Considering that simultaneous detection of xanthine (XA) and hypoxanthine (HXA) has been proved to be a reliable and feasible method for assessing fish freshness, a novel electrochemical sensing platform based on the ZnIn2S4/UiO-66-NH2 modified glassy ...
Debin Song +9 more
doaj +1 more source
Molecules, 2022 The neurotoxic, neuroprotective and MAO-B inhibitory effects of series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides are evaluated.
Magdalena Kondeva-Burdina +5 more
doaj +1 more source
BMC Plant Biology, 2021 Soil salinity is a critical threat to global agriculture. In plants, the accumulation of xanthine activates xanthine dehydrogenase (XDH), which catalyses the oxidation/conversion of xanthine to uric acid to remove excess reactive oxygen species (ROS ...
Tingting Sun +7 more
semanticscholar +1 more source