Results 131 to 140 of about 112,529 (303)
Effect of ELF e.m. fields on metalloprotein redox-active sites
The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals.
Badon, T.+6 more
core
Abstract Background Demographic and clinical factors significantly influence urinary stone composition; however, data from other Arabian Gulf countries still lack further exploration of these variables with the aid of multivariate analyses. This study aims to address this gap by conducting an in‐depth multivariate analysis of the demographic and ...
Hamzah Shehadeh+8 more
wiley +1 more source
Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley +1 more source
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu+18 more
wiley +1 more source
Screening of methanol extracts of sixty plants from Kerman for their potential xanthine oxidase inhibitory activity [PDF]
Introduction: Gout is a chronic metabolic disease in which xanthine oxidase plays a crucial role. Many natural compounds such as various flavonoids have been reported to have inhibitory effect on xanthine oxidase.
Ahmad Gholamhoseinian+2 more
doaj
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin+13 more
wiley +1 more source
The chemistry of xanthine oxidase. 5. Electron-spin resonance of xanthine oxidase solutions [PDF]
Robert C. Bray+2 more
openalex +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source