Results 141 to 150 of about 58,088 (256)

Barbaloin Attenuates Cisplatin‐Induced Hippocampal Neurotoxicity by Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis: In Vivo and In Silico Evidence

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Important Aloe vera phytonutrient, barbaloin, inhibits the neurotoxic effects of cisplatin on hippocampus, which involves reducing oxidative stress, neuroinflammation, and apoptosis, thereby restoring the balance of neurotransmitters and cognition. The generated docking structures with 100‐ns molecular dynamics simulations show stable energy‐minimized ...
Rahamat Unissa Syed, Rihab Akasha, Nancy Mohammad Elafandy, Sally Hassan Abobaker, Afrah Nashmi Al‐Shammari, Lama Abdullah Altwalah, Rawabi Mohammed Menwer Aldafeeri, Amira Ibrahim Mohammed Ahmed Alfaki, Mohd Sajjad Ahmad Khan, Ashgan A. Ahmed   +9 more
wiley   +1 more source

The hitchhiker's guide to feline xanthinuria. [PDF]

J Feline Med Surg
Kim MM, Velie BD, Sheehy PA, Courtman NF, Pritchard EC, Haase B.   +5 more
europepmc   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Metabolite biomarkers present in urine predict alterations in skeletal muscle associated with sarcopenia. [PDF]

Front Aging
Andrade-Vieira R, Feridooni HA, Teixeira A, Deska-Gauthier D, Chang X, Karakach T, Moyer R, Frampton JP.   +7 more
europepmc   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Research progress on the correlation between gut microbiota and the occurrence of hyperuricemia. [PDF]

Front Microbiol
Wang Q, Yan L, Mo Y, Dai Y, Cheng J, Qiu M.   +5 more
europepmc   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Characterization of Gastrointestinal Absorption of Salmon Milt-Derived Oligodeoxyribonucleic Acids in Mice. [PDF]

J Nutr Metab
Hayashi F, Masuo Y, Nishizawa Y, Koike A, Ishimoto T, Kiriyama K, Fujita M, Sutoh K, Kato Y.   +8 more
europepmc   +1 more source

Chemical Profiling and In Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian Erica arborea L. Extracts, Strengthened by Molecular Modeling Analysis

ChemistryOpen, Volume 15, Issue 8, August 2026.
Erica arborea L. from Algeria was valorized via chemical profiling and bioactivity assessment. The EtOAc extract showed the highest levels of polyphenols, flavonoids, and flavonols. It exhibited strong antioxidant (ABTS•+, DPPH•, FRAP) and antibacterial activity (S. aureus, B. subtilis).
Amina Bramki, Ouided Benslama, Fatima Zohra Makhlouf, Anna Andolfi, Zineb Mokhbi, Selsabile Nedjaoum, Chawki Bensouici, Maria Michela Salvatore, Marco Masi   +8 more
wiley   +1 more source

Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
We developed a GalNAc‐conjugated siRNA targeting hepatic XDH, which effectively reduces uric acid production by silencing XDH expression, offering a promising therapeutic approach for hyperuricemia. ABSTRACT Hyperuricemia (HUA) is primarily driven by hepatic overproduction of urate, mediated by xanthine dehydrogenase (XDH).
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui   +12 more
wiley   +1 more source