Unrevealed oligoresveratrols from <i>Shorea parvifolia</i> root bark as xanthine oxidase inhibitors: isolation, <i>in vitro</i> bioassay, quantum studies and structure-based computational profiling. [PDF]
RSC AdvWindah ALL +7 more
europepmc +1 more source
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.Effects of thyroxine (T) and nano‐melatonin (NM) supplementation on cryopreserved Simmental bull semen were evaluated. The combination of thyroxine (0.5 µg/dL) and nano‐melatonin (30 µg/dL) significantly improved post‐thaw sperm motility, membrane integrity, antioxidant status, and fertility while reducing oxidative stress and apoptosis. These findings
Marwa Abonagy +18 more
wiley +1 more source
Crodonsides A-D, four new guaiane-type sesquiterpenoid glycosides from <i>Croton dongnaiensis</i> and their xanthine oxidase inhibitory activities. [PDF]
RSC AdvNga TT +6 more
europepmc +1 more source
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation
Environmental Microbiology, Volume 28, Issue 11, November 2026.Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathways are not universally conserved. These findings refine genome‐based predictions of microbial metabolism and improve understanding of metalloenzyme assembly
R. A. Dawson, M. Hernández
wiley +1 more source
A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam +7 more
wiley +2 more sources
Xanthine oxidase inhibitory evaluation of prenylated flavonoids from peanut (<i>Arachis hypogaea</i> L.) shells: <i>in vitro</i> and <i>in silico</i> molecular docking studies. [PDF]
RSC AdvHoang PTN +9 more
europepmc +1 more source
Microbial Biotechnology, Volume 19, Issue 11, November 2026.Reprogramming native cryptic plasmids of Escherichia coli Nissle 1917 enabled antibiotic‐selection‐free and oxygen‐adaptive urate degradation. The engineered strain reduced uric acid levels and alleviated hyperuricemia‐associated renal and inflammatory abnormalities in mice, supporting endogenous plasmid engineering as a strategy for live ...
Yuan Chi +5 more
wiley +1 more source
Pyrimidine and Purine Concentrations in Cord, Preterm and Term Infant Plasma Compared to Maternal Values-An Observational Study. [PDF]
NutrientsMinarski M +7 more
europepmc +1 more source
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley +1 more source