Results 11 to 20 of about 89,320 (324)
Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation. [PDF]
J Sci Food AgricAbstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Bencsik T +6 more
europepmc +2 more sources
PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine. [PDF]
Clin Transl SciABSTRACT Leukopenia is a common dose‐dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine‐induced leukopenia but only explain 25% of cases. Thus, we aimed to identify novel genetic risk factors among TPMT and NUDT15 normal metabolizers through a genome‐wide ...
Daniel LL +15 more
europepmc +2 more sources
The specificity of xanthine oxidase [PDF]
Biochemical Journal, 1938 Vernon Booth
openaire +4 more sources
The Distribution of Xanthine Oxidase I [PDF]
Biochemical Journal, 1926 Edward J. Morgan
openalex +2 more sources
Molecules, 2022 The neurotoxic, neuroprotective and MAO-B inhibitory effects of series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides are evaluated.
Magdalena Kondeva-Burdina +5 more
doaj +1 more source
The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors
Oxidative Medicine and Cellular Longevity, 2021 Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA).
Ning Liu +8 more
semanticscholar +1 more source
Animals, 2023 Reducing the alimentary purine intake contributes to the prevention of purine (especially xanthine) urolith formation, a common adverse effect of allopurinol treatment in dogs with Leishmania infections. Analyses of the purine content are not required in
Melanie Kaempfle +3 more
doaj +1 more source
Chemosensors, 2022 Considering that simultaneous detection of xanthine (XA) and hypoxanthine (HXA) has been proved to be a reliable and feasible method for assessing fish freshness, a novel electrochemical sensing platform based on the ZnIn2S4/UiO-66-NH2 modified glassy ...
Debin Song +9 more
doaj +1 more source
Biology, 2023 Hyperuricemia, an abnormally high level of blood uric acid, is a major risk factor for gout. Although xanthine oxidase inhibitors were clinically used to lower blood uric acid level, the concerned side effects restricted their utilization. In this study,
Kuo-Ching Huang +8 more
doaj +1 more source