Results 31 to 40 of about 107,799 (290)

Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]

, 1990
The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna, Adkison, Eiseman, Granger, Green, Hanks, Hoffee, James T. Snyder, Kamada, Kamiike, Kamiike, Kizaki, Lanir, Lee, Lee, LeMasters, LeMasters, Leonard Makowka, Marotto, Marubayashi, Marubayashi, McCord, Nishida, Parks, Prakash N. Rao, Randy S. Rubin, Rubio, Teperman, Thomas E. Starzl, Thomas R. Walsh, Thomas Weber, Turner, Van Thiel   +32 more
core   +1 more source

Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem

Biomedicines, 2023
Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases.
Deborah E. M. Baliellas, Marcelo P. Barros, Cristina V. Vardaris, Maísa Guariroba, Sandra C. Poppe, Maria F. Martins, Álvaro A. F. Pereira, Eduardo F. Bondan   +7 more
doaj   +1 more source

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J., Harrow, C., Lees, K.R., Muir, S.W., Sattar, N., Walters, M.R., Weir, C.J.   +6 more
core   +1 more source

Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives [PDF]

The Ukrainian Biochemical Journal, 2017
This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was found that the most active compound 8-[2-[(3-methoxyphenyl)methylidene]hydrazine-1-yl]-3-methyl-7-(
M. V. Protopopov, O. V. Ostrynska, D. H. Ivanchenko, S. A. Starosyla, V. G. Bdzhola, M. I. Romanenko, S. M. Yarmoluk   +6 more
doaj   +1 more source

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A_2B Receptor Binding Affinity

Pharmaceuticals, 2021
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer.
Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel   +9 more
doaj   +1 more source

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

Molecules, 2019
8-Arylethynylxanthine derivatives are potent, selective adenosine A2A receptor antagonists, which represent (potential) therapeutics for Parkinson’s disease, Alzheimer’s dementia, and the immunotherapy of cancer.
Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller   +3 more
doaj   +1 more source

Nanomaterial-Doped Xerogels for Biosensing Measurements of Xanthine in Clinical and Industrial Applications

Gels, 2023
First-generation amperometric xanthine (XAN) biosensors, assembled via layer-by-layer methodology and featuring xerogels doped with gold nanoparticles (Au-NPs), were the focus of this study and involved both fundamental exploration of the materials as ...
Quang Minh Dang, Ann H. Wemple, Michael C. Leopold   +2 more
doaj   +1 more source

Assessing Meat Freshness via Nanotechnology Biosensors: Is the World Prepared for Lightning-Fast Pace Methods?

Biosensors, 2023
In the rapidly evolving field of food science, nanotechnology-based biosensors are one of the most intriguing techniques for tracking meat freshness.
Wen Xia Ling Felicia, Kobun Rovina, Nasir Md Nur ‘Aqilah, Joseph Merillyn Vonnie, Koh Wee Yin, Nurul Huda   +5 more
doaj   +1 more source

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, EarlyView.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Simultaneous Electrochemical Analysis of Uric Acid and Xanthine in Human Saliva and Serum Samples Using a 3D Reduced Graphene Oxide Nanocomposite-Modified Electrode

Chemosensors, 2023
Accurate and effective diagnosis and individualized management of gout can be potentially achieved by detecting uric acid (UA) and xanthine (XT) simultaneously using an easy-to-use method.
Seong-Hyun Han, Ki Won Moon, Yun Jong Lee, Gi-Ja Lee   +3 more
doaj   +1 more source