Results 31 to 40 of about 89,320 (324)
Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives [PDF]
The Ukrainian Biochemical Journal, 2017 This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was found that the most active compound 8-[2-[(3-methoxyphenyl)methylidene]hydrazine-1-yl]-3-methyl-7-(
M. V. Protopopov +6 more
doaj +1 more source
Extraterrestrial nucleobases in the Murchison meteorite [PDF]
Earth and Planetary Science Letters 270, 130-136. 15 June 2008, 2008 Carbon-rich meteorites, carbonaceous chondrites, contain many biologically relevant organic molecules and delivered prebiotic material to the young Earth. We present compound-specific carbon isotope data indicating that measured purine and pyrimidine compounds are indigenous components of the Murchison meteorite.
arxiv +1 more source
Biosensors, 2023 In the rapidly evolving field of food science, nanotechnology-based biosensors are one of the most intriguing techniques for tracking meat freshness.
Wen Xia Ling Felicia +5 more
doaj +1 more source
Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview
Medical Science Monitor, 2016 Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS).
Changyi J. Chen, Jianming Lü, Q. Yao
semanticscholar +1 more source
Chemosensors, 2023 Accurate and effective diagnosis and individualized management of gout can be potentially achieved by detecting uric acid (UA) and xanthine (XT) simultaneously using an easy-to-use method.
Seong-Hyun Han +3 more
doaj +1 more source
Biomedicines, 2023 Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases.
Deborah E. M. Baliellas +7 more
doaj +1 more source
Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme
International Journal of Molecular Sciences, 2019 Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions of its ...
Violetta Mohos +9 more
semanticscholar +1 more source
Frontiers in Chemistry, 2019 Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6 ...
Daniel Marx +4 more
doaj +1 more source
MOCOS‐associated renal syndrome in a Brown Swiss cattle
Journal of Veterinary Internal Medicine, 2023 Background A recessive form of MOCOS‐associated xanthinuria type II is described in Tyrolean grey cattle. A similar case was identified in a 5‐month‐old Brown Swiss calf with hoof overgrowth, rough coat, urine sediment, and pneumonia.
Joana G. P. Jacinto +7 more
doaj +1 more source
Gels, 2023 First-generation amperometric xanthine (XAN) biosensors, assembled via layer-by-layer methodology and featuring xerogels doped with gold nanoparticles (Au-NPs), were the focus of this study and involved both fundamental exploration of the materials as ...
Quang Minh Dang +2 more
doaj +1 more source