Results 41 to 50 of about 112,529 (303)
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
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Biomedicines, 2023 Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases.
Deborah E. M. Baliellas +7 more
doaj +1 more source
Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]
, 2019 Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J. +2 more
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PharmaceuticalsAdenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko +8 more
doaj +1 more source
MOCOS‐associated renal syndrome in a Brown Swiss cattle
Journal of Veterinary Internal Medicine, 2023 Background A recessive form of MOCOS‐associated xanthinuria type II is described in Tyrolean grey cattle. A similar case was identified in a 5‐month‐old Brown Swiss calf with hoof overgrowth, rough coat, urine sediment, and pneumonia.
Joana G. P. Jacinto +7 more
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Gels, 2023 First-generation amperometric xanthine (XAN) biosensors, assembled via layer-by-layer methodology and featuring xerogels doped with gold nanoparticles (Au-NPs), were the focus of this study and involved both fundamental exploration of the materials as ...
Quang Minh Dang +2 more
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Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]
, 2015 Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju +11 more
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Pharmaceuticals, 2021 The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer.
Marcel Lindemann +9 more
doaj +1 more source
Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]
, 1990 The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna +32 more
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Effect of oxidative stress on the activity of human osteoblastic MG63 cells
口腔疾病防治, 2017 Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj +1 more source