Results 41 to 50 of about 89,320 (324)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A_2B Receptor Binding Affinity

Pharmaceuticals, 2021
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer.
Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel   +9 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

Molecules, 2019
8-Arylethynylxanthine derivatives are potent, selective adenosine A2A receptor antagonists, which represent (potential) therapeutics for Parkinson’s disease, Alzheimer’s dementia, and the immunotherapy of cancer.
Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller   +3 more
doaj   +1 more source

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

Pharmacological Reviews, 2006
The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades.
P. Pacher, A. Nivorozhkin, C. Szabó
semanticscholar   +1 more source

First case of hereditary xanthinuria in a Moroccan family

PAMJ Clinical Medicine, 2019
The xanthinuria is a rare hereditary autosomal recessive disease. It is related to xanthine oxidase deficiency also known as xanthine dehydrogenase, an enzyme involved in the metabolism of purine bases.
Aicha Ezoubeiri, Asma Labaali, Naima Fdil, Jean-François Benoist, Laila Chabaa   +4 more
doaj   +1 more source

Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects

Oxidative Medicine and Cellular Longevity, 2015
Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species.
M. Battelli, L. Polito, M. Bortolotti, A. Bolognesi   +3 more
semanticscholar   +1 more source

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Nature Communications, 2015
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
A. Ives, Johji Nomura, F. Martinon, T. Roger, D. Leroy, J. Miner, G. Simon, N. Busso, A. So   +8 more
semanticscholar   +1 more source

Deep Supramolecular Language Processing for Co‐Crystal Prediction

Angewandte Chemie, EarlyView.
DeepCocrystal is a deep learning model that predicts co‐crystal formation by learning supramolecular interactions from molecular string representations. It achieves high accuracy, estimates uncertainty, and offers interpretable insights into its predictions. Validated prospectively, DeepCocrystal discovered novel diflunisal co‐crystals and is available
Rebecca Birolo, Rıza Özçelik, Andrea Aramini, Roberto Gobetto, Michele R. Chierotti, Francesca Grisoni   +5 more
wiley   +2 more sources

Synthesis and physical-chemical properties of 8-bromo-3-methyl-7-α-methylbenzylxanthine derivatives

Фармацевтичний журнал, 2018
The level of modern pharmaceutical science development is determined by the introduction in medical practice of new effective and non-toxic drugs. The problem of new drugs search depends on the presence in the arsenal of pharmacologists significant ...
D. G. Ivanchenko
doaj   +1 more source