Results 61 to 70 of about 75,914 (267)

An amperometric biosensor for xanthine determination prepared from xanthine oxidase immobilized in polypyrrole film

, 2006
In order to prepare a biosensor for the determination of xanthine, electropolymerization of pyrrole on Pt surface was carried out with an electrochemical cell containing pyrrole, ferrocene (as a electron mediator) and tetrabutylamonium tetrafluoroborat ...
Arslan, FATMA, Yasar, A, Kilic, E
core   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

MOCOS‐associated renal syndrome in a Brown Swiss cattle

Journal of Veterinary Internal Medicine, 2023
Background A recessive form of MOCOS‐associated xanthinuria type II is described in Tyrolean grey cattle. A similar case was identified in a 5‐month‐old Brown Swiss calf with hoof overgrowth, rough coat, urine sediment, and pneumonia.
Joana G. P. Jacinto, Leonore Bettina Küchler, Laureen M. Peters, Elke Van der Vekens, Corinne Gurtner, Franz R. Seefried, Mireille Meylan, Cord Drögemüller   +7 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Der Abbau methylierter Xanthine

, 1910
DER ABBAU METHYLIERTER XANTHINE Details: Zeitschrift für physiologische Chemie: 1.1877-20.1895 Hoppe-Seyler's Zeitschrift für physiologische Chemie: 21.1895- 112.1921 (-) Hoppe-Seyler's Zeitschrift für Physiologische Chemie (67) ( - )
Schmid, Julius
core   +1 more source

Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases

Frontiers in Endocrinology
Xanthine oxidoreductase (XOR) catalyzes the final steps of purine catabolism: the oxidation of hypoxanthine to xanthine, and xanthine to UA. XOR exists as interconvertible proteoforms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO).
Kendra L. Nelson, Kendra L. Nelson, Venkata Saroja Voruganti, Venkata Saroja Voruganti   +3 more
doaj   +1 more source

Effect of oxidative stress on the activity of human osteoblastic MG63 cells

口腔疾病防治, 2017
Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj   +1 more source

Synthesis and physical-chemical properties of 8-aminoderivatives of 7-m-bromobenzyl-3-methylxanthine

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The current stage of scientific and technological progress in pharmaceutical science is associated with the development of the targeted synthesis of biologically active compounds and the creation of new highly effective and low-toxic drugs on their basis
M. I. Romanenko , D. H. Ivanchenko, K. V. Aleksandrova, O. B. Makoid   +3 more
doaj   +1 more source

Xanthine Oxidoreductase Inhibitors

, 2020
Xanthine oxidase inhibitors are primarily used in the clinical prevention and treatment of gout associated with hyperuricemia. The archetypal xanthine oxidase inhibitor, Allopurinol has been shown to have other beneficial effects such as a reduction in ...
Keeran Vickneson, Jacob George, George, Jacob, Vickneson, Keeran   +3 more
core   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source