Results 71 to 80 of about 89,320 (324)

Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition

, 2015
Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Excessive production and/or inadequate excretion of uric acid results in hyperuricemia.
D. Kostić, Danica S. Dimitrijević, G. Stojanović, Ivan R. Palić, A. Đorđević, Jovana D. Ickovski   +5 more
semanticscholar   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

Effect of ELF e.m. fields on metalloprotein redox-active sites [PDF]

arXiv, 2008
The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and ...
arxiv  

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

Scientific Reports, 2014
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress.
Johji Nomura, N. Busso, A. Ives, Chieko Matsui, Syunsuke Tsujimoto, Takashi Shirakura, Mizuho Tamura, Tsunefumi Kobayashi, A. So, Yoshihiro Yamanaka   +9 more
semanticscholar   +1 more source

Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations

Angewandte Chemie International Edition, EarlyView.
Efficient electrophotochemical C─H fluoroalkylation of complex bioactive substrates with abundant fluoroalkyl carboxylic acids employing an inexpensive iron(III) catalyst accompanied by hydrogen evolution reaction has been developed. Abstract Chemo‐ and site‐selective functionalization of complex molecules poses a fundamental challenge.
Vladimir Motornov, Sven Trienes, Simonetta Resta, João C. A. Oliveira, Zhipeng Lin, Zhi Liu, Tristan von Münchow, Claudia Stückl, Lutz Ackermann   +8 more
wiley   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Propentofylline reduces glial scar development following gliotoxic damage in the rat brainstem

Arquivos de Neuro-Psiquiatria
Propentofylline is a xanthine derivative that depresses activation of glial cells, whose responses contribute to neural tissue damage during inflammation.
Eduardo Fernandes Bondan, Maria de Fátima Monteiro Martins, Pietro Domingues Dossa, Lígia Bocamino Viebig, Carolina Vieira Cardoso, João Lopes Martins Júnior, Maria Martha Bernardi   +6 more
doaj   +1 more source

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

Quantification of Uric Acid or Xanthine in Plant Samples

Bio-Protocol, 2015
We developed this protocol to assay and quantify the content of uric acid or xanthine in various tissues of Arabidopsis thaliana mutant lines with defective urate oxidase or xanthine dehydrogenase1 and in their complementation and suppressor lines (Hauck
Oliver Hauck, Claus-Peter Witte
doaj   +1 more source

The fate of thiopurine metabolites after switching to low‐dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy, Hedwig M. A. D'Agnolo, Nanne K. H. de Boer, Chris J. J. Mulder, Luc J. J. Derijks   +4 more
wiley   +1 more source