Results 71 to 80 of about 112,529 (303)
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014 Introduction It has been foundearlier[1-5]that 8-substituted of 7-(2-hydroxy-3-R-oxypropyl-1)-3-methylxanthine show rather high diuretic, anti-inflammatory, analgesic, antioxidant and hypolipidemic action.Meanwhile, works of international researchers ...
M. I. Romanenko +4 more
doaj +1 more source
Implication of changes in xanthine oxidase activity following hemodialysis
BMC Nephrology, 2023 Background Xanthine oxidase activity has a key role in the development of oxidative stress and progression of cardiovascular diseases. However, the change of xanthine oxidase activity following hemodialysis and its prognostic impact remain uncertain ...
Hayato Fujioka +5 more
doaj +1 more source
The action of xanthin and methyl xanthins on the isolated intestine
Experimental Biology and Medicine, 1916 The tests were made with different concentrations of xanthin and its derivatives dissolved in Locke's solution which were carried out on segments of different parts of the intestine of the rabbit. Sodium xanthin in concentrations of 1 : 2,000 and 1 : 1,000 caused increased tonus which was more pronounced in the large than in the small intestine.
William Salant, E. W. Schwartze
openaire +2 more sources
An investigation of the antiplatelet effects of succinobucol (AGI-1067) [PDF]
, 2016 Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet–platelet and platelet–vessel wall interactions, the aim of this study was to establish if antioxidant ...
Gnanadesika, Sukanya +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
SERS, XPS and DFT Study of Xanthine Adsorbed on Citrate-Stabilized Gold Nanoparticles
Sensors, 2019 We have studied the adsorption of xanthine, a nucleobase present in human tissue and fluids that is involved in important metabolic processes, on citrate-reduced gold colloidal nanoparticles by means of surface-enhanced Raman scattering (SERS ...
Stefano Caporali +3 more
doaj +1 more source
Synthesis and physical-chemical properties of 8-aminoderivatives of 7-m-bromobenzyl-3-methylxanthine
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The current stage of scientific and technological progress in pharmaceutical science is associated with the development of the targeted synthesis of biologically active compounds and the creation of new highly effective and low-toxic drugs on their basis
M. I. Romanenko +3 more
doaj +1 more source
Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]
, 2015 SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas +21 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi +11 more
wiley +1 more source
Oxidative Stress Detection With Escherichia Coli Harboring A katG\u27::lux Fusion [PDF]
, 1996 A plasmid containing a transcriptional fusion of the Escherichia coli katG promoter to a truncated Vibrio fischeri lux operon (luxCDABE) was constructed. An E.
Belkin, S. +4 more
core +2 more sources