The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells [PDF]
Redox Biology, 2023 The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano +4 more
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Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I [PDF]
Advances in Laboratory Medicine, 2021 Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina +5 more
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Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights [PDF]
MetabolitesBackground: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen +6 more
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Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases [PDF]
Frontiers in EndocrinologyXanthine oxidoreductase (XOR) catalyzes the final steps of purine catabolism: the oxidation of hypoxanthine to xanthine, and xanthine to UA. XOR exists as interconvertible proteoforms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO).
Kendra L. Nelson +3 more
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Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Redox Biology, 2021 Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from a complicated evolutionary process that assigned it many physiological roles.
Massimo Bortolotti +2 more
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Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease [PDF]
AntioxidantsThe majority of naturally occurring mutations of the human gene XDH, are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and ...
Gianmichele Massimo +4 more
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XDH-1 inactivation causes xanthine stone formation in Caenorhabditis elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell. [PDF]
PLoS BiologyXanthine dehydrogenase (XDH) is a molybdenum cofactor (Moco) requiring enzyme that catabolizes hypoxanthine into xanthine and xanthine into uric acid, the final steps in purine catabolism.
Jennifer Snoozy +8 more
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Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells [PDF]
Frontiers in ImmunologyBackgroundInterleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production ...
Sadiq Umar +4 more
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A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses
Crop Journal, 2022 Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine.
Jiangmin Xu +11 more
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Biomedicines, 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism.
Mai Sekine +2 more
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