The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells [PDF]
Redox Biology, 2023 The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano +4 more
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Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I [PDF]
Advances in Laboratory Medicine, 2021 Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina +5 more
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Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights [PDF]
MetabolitesBackground: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen +6 more
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Xanthine dehydrogenase as a prognostic biomarker related to tumor immunology in hepatocellular carcinoma [PDF]
Cancer Cell International, 2021 Background Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system.
Zhen Lin +5 more
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Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease [PDF]
AntioxidantsThe majority of naturally occurring mutations of the human gene XDH, are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and ...
Gianmichele Massimo +4 more
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Purification and Properties of Chicken Liver Xanthine Dehydrogenase
Journal of Biological Chemistry, 1967 Chicken liver xanthine dehydrogenase, which catalyzes the reduction of DPN+ by various purines and aldehydes, was purified to near homogeneity. It exhibits a molecular weight of about 300,000, a molar complement, flavin to molybdenum to iron to labile sulfide, of 2:2:8:8, and an absorption spectrum resembling those of milk xanthine oxidase and rabbit ...
K.V. Rajagopalan, Philip Handler
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Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice [PDF]
Scientific ReportsIn most patients with type 1 xanthinuria caused by mutations in the xanthine dehydrogenase gene (XDH), no clinical complications, except for urinary stones, are observed. In contrast, all Xdh(− / −) mice die due to renal failure before reaching adulthood
Kazuki Terada +6 more
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Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning. [PDF]
FASEB JCyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Bebarta VS, Nath AK.
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Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield. [PDF]
Rice (N Y), 2020 Han R, He X, Pan X, Shi Q, Wu Z.
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Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]
AGE, 1997 Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
Hae Young Chung +7 more
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