Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease [PDF]
AntioxidantsThe majority of naturally occurring mutations of the human gene XDH, are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and ...
Gianmichele Massimo +4 more
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The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells [PDF]
Redox Biology, 2023 The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano +4 more
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Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I [PDF]
Advances in Laboratory Medicine, 2021 Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina +5 more
doaj +2 more sources
Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights [PDF]
MetabolitesBackground: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen +6 more
doaj +2 more sources
Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Redox Biology, 2021 Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from a complicated evolutionary process that assigned it many physiological roles.
Massimo Bortolotti +2 more
exaly +3 more sources
Xanthine dehydrogenase as a prognostic biomarker related to tumor immunology in hepatocellular carcinoma. [PDF]
Cancer Cell Int, 2021 Lin Z +5 more
europepmc +3 more sources
Xanthine Dehydrogenase Activities of Insects
Japanese journal of applied entomology and zoology, 1961 2, 3の昆虫を材料にしてキサンチン脱水素酵素の活性度を測定した結果1. りんし目昆虫(Barathra brassicaeおよびCephonodes hylas)のキサンチン酸化酵素系は脱水素酵素によって触媒されていることを明らかにした。2. 幼虫の各組織におけるキサンチン脱水素酵素活性度は脂肪組織およびマルピーギ管に高く,中腸壁では低い,また直腸壁,皮膚および血液には認められなかった。3. ワモンゴキブリ(Periplaneta americana)のキサンチン脱水素酵素活性度はマルピーギ管,脂肪組織,後腸壁および中腸壁に認められたが,前腸壁には活性度はないようである。
Y. Hayashi
openalex +3 more sources
XDH-1 inactivation causes xanthine stone formation in Caenorhabditis elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell. [PDF]
PLoS BiologyXanthine dehydrogenase (XDH) is a molybdenum cofactor (Moco) requiring enzyme that catabolizes hypoxanthine into xanthine and xanthine into uric acid, the final steps in purine catabolism.
Jennifer Snoozy +8 more
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Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2. [PDF]
J Dev Biol, 2023 Starr LA +6 more
europepmc +3 more sources
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation [PDF]
Nature Communications, 2015 Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
Annette Ives +2 more
exaly +3 more sources