Results 31 to 40 of about 16,447 (208)

An in vitro System for Studying Pteridine Biosynthesis In Drosophila melanogaster

Pteridines, 1991
In vitro organ culture is a system especially useful for the study of metabolic pathways and their regulation. This report applies such a system to the study of the biosynthesis of pteridines in Drosophila melanogaster, determining in vitro optimal ...
Escriche B., Silva F. J.
doaj   +1 more source

Some opportunities of using xanthine oxidase inhibitors

Современная ревматология, 2019
The review presents modern concepts of the role of xanthine oxidase (XO) in the pathogenesis of a number of diseases. It has been shown that XO activity can be associated with the development and progression not only of gout, but, possibly, diabetes ...
O. V. Zhelyabina, M. S. Eliseev
doaj   +1 more source

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

Frontiers in Microbiology, 2022
The increasing incidence of drug-resistant tuberculosis is still an emergency for global public health and a major obstacle to tuberculosis treatment.
Wanyan Deng, Wanyan Deng, Wanyan Deng, Zengzhang Zheng, Zengzhang Zheng, Yi Chen, Maoyi Yang, Jun Yan, Wu Li, Wu Li, Jie Zeng, Jie Zeng, Jianping Xie, Sitang Gong, Sitang Gong, Huasong Zeng, Huasong Zeng   +16 more
doaj   +1 more source

Irreversible conversion of xanthine dehydrogenase into xanthine oxidase by a mitochondrial protease

FEBS Letters, 1999
Irreversible conversion of xanthine dehydrogenase (XDH) to its oxygen free radical producing oxidase (XO) form occurs through an uncharacterized proteolytic process, which was studied in human liver. Upon incubation of fresh unfrozen liver cytosol, XDH remained intact. When recombinant human XDH was coincubated with subcellular fractions of human liver,
Mika Saksela, Risto Lapatto, Kari O. Raivio   +2 more
openaire   +3 more sources

Discriminating Susceptibility of Xanthine Oxidoreductase Family to Metals

Microbiology Spectrum, 2023
The xanthine oxidoreductase (XOR) family are metal-containing enzymes that use the molybdenum cofactor (Moco), 2Fe-2S clusters, and flavin adenine dinucleotide (FAD) for their catalytic activity.
Anne-Soisig Steunou, Marion Babot, Anne Durand, Marie-Line Bourbon, Sylviane Liotenberg, Guylaine Miotello, Jean Armengaud, Soufian Ouchane   +7 more
doaj   +1 more source

Using Next-Generation Sequencing to Identify a Mutation in Human MCSU that is Responsible for Type II Xanthinuria

Cellular Physiology and Biochemistry, 2015
Background: Hypouricemia is caused by various diseases and disorders, such as hepatic failure, Fanconi renotubular syndrome, nutritional deficiencies and genetic defects.
Yunan Zhou, Xueguang Zhang, Rui Ding, Zuoxiang Li, Quan Hong, Yan Wang, Wei Zheng, Xiaodong Geng, Meng Fan, Guangyan Cai, Xiangmei Chen, Di Wu   +11 more
doaj   +1 more source

Multiple molecular forms of xanthine dehydrogenase and related enzymes. IV. The relationship of aldehyde oxidase to xanthine dehydrogenase [PDF]

Biochemical Genetics, 1971
Uploaded by Plazi for TaxoDros. We do not have abstracts.
Edward Glassman, J. F. Collins, E. J. Duke   +2 more
openaire   +3 more sources

Gene Location for Molybdenum Cofactor Deficiency

Pediatric Neurology Briefs, 1998
Linkage of a molybdenum cofactor deficiency (MoCoD) gene to an 8-cM region on chromosome 6p21.3 has been localized by homozygosity mapping in 2 consanguineous affected kindreds of Israeli-Arab origin, including 5 patients, at the Department of Genetics ...
J Gordon Millichap
doaj   +1 more source

Xanthine dehydrogenase is transported to the Drosophila eye. [PDF]

Genetics, 1989
Abstract The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a deficiency in the red eye pigment.
Stephen H. Clark, Arthur Chovnick, A G Reaume   +2 more
openaire   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source