Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley +1 more source
Role of protein structure in drug discovery [PDF]
, 2016 Many pharmaceuticals currently available were discovered either during the screening of natural of synthetic product libraries or by serendipitous observation.
Bonetta, Rosalin +5 more
core +1 more source
Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]
, 2015 SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas +21 more
core +3 more sources
Functional studies on oligotropha carboxidovorans molybdenum–copper CO dehydrogenase produced in escherichia coli [PDF]
, 2018 The Mo/Cu-dependent CO dehydrogenase (CODH) from Oligotropha carboxidovorans is an enzyme that is able to catalyze both the oxidation of CO to CO2 and the oxidation of H2 to protons and electrons. Despite the close to atomic resolution structure (1.1 Å),
Duffus, Benjamin R. +3 more
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Impact of Plasma Xanthine Oxidoreductase Activity in Patients with Heart Failure with Preserved Ejection Fraction [PDF]
, 2020 Ken Watanabe +11 more
openalex +1 more source
Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes: a cross-sectional study in a hospital setting [PDF]
, 2020 Tomoko Okuyama +8 more
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AB0138 XANTHINE OXIDOREDUCTASE: BLOOD PROFILE IN SYSTEMIC CONNECTIVE TISSUE DISEASES [PDF]
, 2022 E. Mozgovaya +5 more
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Inhibition Mechanisms of Xanthine Oxidoreductase Inhibitors
Nihon Ika Daigaku Igakkai Zasshi, 2007 Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR block conversion of the oxypurines (hypoxanthine and xanthine) to uric acid, thus decreasing serum concentration of uric acid.
openaire +2 more sources
Nitric Oxide In Health And Diseases [PDF]
, 2012 Nitric Oxide (NO) is color less, readily diffusible, highly reactive lipophilic and chemically unstable Free radical gas. NO is formed form arginine by enzyme nitric Oxide synthase. No acts in a paracrine or even autocrine manner. It causes asodilatation,
A.K. Anand, Chinmay Shah, R.Dixit
core
Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
Atherosclerosis, 2014 Endothelial xanthine oxidoreductase (XOR) together with NAD(P)H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO production and vascular function. The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and ...
BATTELLI, MARIA GIULIA +2 more
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