Results 131 to 140 of about 77,092 (210)

Distribution of xanthine oxidoreductase activity in human tissues--a histochemical and biochemical study

, 1992
Localization of the activity of both the dehydrogenase and oxidase forms of xanthine oxidoreductase were studied in biopsy and postmortem specimens of various human tissues with a recently developed histochemical method using unfixed cryostat sections ...
van Noorden, C. J., Kooij, A., Schijns, M., Frederiks, W. M., James, J.   +4 more
core  

Nuclear factor Y activates the human xanthine oxidoreductase gene promoter

, 2000
To study the regulation of the human xanthine oxidoreductase (XOR) gene, we cloned 1.9 kb of the promoter region. In reporter gene assays, a construct encompassing nucleotides between −142 to +42 conferred maximal basal activity of the XOR promoter in ...
Lapatto, Risto, Risto Lapatto, Martelin, Eeva, Raivio, Kari O., Eeva Martelin, Kari O. Raivio, Palvimo, Jorma J., Jorma J. Palvimo   +7 more
core   +1 more source

Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C

, 2007
The modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles ...
Phillips, Roger M, Volpato, Milene
core  

Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a critical review

Frontiers in Bioengineering and Biotechnology
Atherosclerotic cardiovascular disease (ACD) is the leading cause of death worldwide. The gold standard of treatment is the implantation of a permanent stent implant that is often associated with complications such as thrombus formation, vascular ...
Janina Mayers, Brianna Hofman, Indie Sobiech, Maria P. Kwesiga   +3 more
doaj   +1 more source

Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases

Hypertension Research, 2022
H. Sekizuka
semanticscholar   +1 more source

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

, 2019
Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki)
Ehirchiou, D., Castelblanco, M., Acha-Orbea, H., Chobaz, V., Nishino, T., Kusano, T., Okamoto, K., Busso, N., Nasi, S., Lavanchy, C., Matsumura, T., So, A.   +11 more
core   +1 more source

Unveiling the anti-gout potential of terpenes isolated from Penicillium sp. supported by in silico studies

Future Journal of Pharmaceutical Sciences
Background Genus Penicillium represents one of the most prolific fungi in terms of biosynthesis of bioactive secondary metabolites. This review aims to survey the reported terpenoids isolated from different species of genus Penicillium and virtually ...
Abdelrhman M. Mohamed, Shaza H. Aly, Ahmed M. Elissawy, Mohamed A. Elanany, Rakesh K. Bachheti, Abdel Nasser B. Singab   +5 more
doaj   +1 more source

Inhibition Mechanisms of Xanthine Oxidoreductase Inhibitors

Nihon Ika Daigaku Igakkai Zasshi, 2007
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR block conversion of the oxypurines (hypoxanthine and xanthine) to uric acid, thus decreasing serum concentration of uric acid.
openaire   +2 more sources

Association of plasma xanthine oxidoreductase activity with vascular endothelial function independent of serum uric acid level: MedCity21 health examination registry. [PDF]

Int J Cardiol Heart Vasc, 2023
Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Ihara Y, Imai T, Nagata Y, Morioka T, Mori K, Imanishi Y, Watanabe T, Emoto M.   +12 more
europepmc   +1 more source

An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

Vascular Health and Risk Management, 2017
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main ...
Bove M, Cicero AFG, Veronesi M, Borghi C
doaj