Results 141 to 150 of about 38,964 (184)
Some of the next articles are maybe not open access.
FEBS Journal, 2008
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and ...
Emil F. Pai +2 more
exaly +3 more sources
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and ...
Emil F. Pai +2 more
exaly +3 more sources
International Journal of Molecular Sciences, 2012 Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O2.
Kimiyoshi Ichida +2 more
exaly +2 more sources
Structure and Function of Xanthine Oxidoreductase
European Journal of Inorganic Chemistry, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Russ Hille
exaly +2 more sources
Enzymes Indigenous to Milk: Xanthine Oxidoreductase
2022Milk xanthine oxidase (XO) plays a first-line immune defense role in the mouth and gut of neonatal mammals, before their adaptive immune system develops. XO generates hydrogen peroxide, which is then utilized by lactoperoxidase to produce a range of powerful free radicals that have bactericidal and bacteriostatic effects, including against ...
Zhengzheng Zou +3 more
openaire +2 more sources
Regulation of xanthine oxidoreductase by intracellular iron
American Journal of Physiology-Cell Physiology, 2002Xanthine oxidoreductase (XOR) may produce reactive oxygen species and play a role in ischemia-reperfusion injury. Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression.
Eeva, Martelin +2 more
openaire +2 more sources
Xanthine oxidoreductase in respiratory and cardiovascular disorders
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension.
Adel, Boueiz +2 more
openaire +2 more sources
Nucleosides, Nucleotides and Nucleic Acids, 2008
Inhibitors of xanthine oxidoreductase block conversion of xanthine to uric acid and are therefore potentially useful for treatment of hyperuricemia or gout. We determined the crystal structure of reduced bovine milk xanthine oxidoreductase complexed with oxipurinol at 2.0 A resolution.
Emil F. Pai +2 more
exaly +3 more sources
Inhibitors of xanthine oxidoreductase block conversion of xanthine to uric acid and are therefore potentially useful for treatment of hyperuricemia or gout. We determined the crystal structure of reduced bovine milk xanthine oxidoreductase complexed with oxipurinol at 2.0 A resolution.
Emil F. Pai +2 more
exaly +3 more sources
FEBS Letters, 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH ...
Nigel Benjamin +2 more
exaly +2 more sources
Absence of xanthine oxidoreductase activity in human myocardium
Cardiovascular Research, 1991The aim was to examine whether or not xanthine oxidase activity may be a significant source of oxygen derived free radicals in the human heart.Xanthine oxidoreductase activity of human myocardium was assayed in vitro. In addition, tests were performed to assess whether or not endogenous inhibitors of the enzyme were present in myocardial homogenates ...
T, Podzuweit +5 more
openaire +4 more sources
Xanthine oxidoreductase and its inhibitors: relevance for gout
Clinical Science, 2016Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism and converts hypoxanthine to xanthine, and xanthine into uric acid. When concentrations of uric acid exceed its biochemical saturation point, crystals of uric acid, in the form of monosodium urate, emerge and can predispose an individual to gout, the commonest form of ...
Richard O, Day +4 more
openaire +2 more sources