Results 161 to 170 of about 77,092 (210)
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Nucleosides, Nucleotides and Nucleic Acids, 2008
Inhibitors of xanthine oxidoreductase block conversion of xanthine to uric acid and are therefore potentially useful for treatment of hyperuricemia or gout. We determined the crystal structure of reduced bovine milk xanthine oxidoreductase complexed with oxipurinol at 2.0 A resolution.
Ken Okamoto +2 more
exaly +3 more sources
Inhibitors of xanthine oxidoreductase block conversion of xanthine to uric acid and are therefore potentially useful for treatment of hyperuricemia or gout. We determined the crystal structure of reduced bovine milk xanthine oxidoreductase complexed with oxipurinol at 2.0 A resolution.
Ken Okamoto +2 more
exaly +3 more sources
Xanthine Oxidoreductase in the Pathogenesis of Endothelial Dysfunction: An Update
Current Hypertension ReviewsAbstract:Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in the formation of uric acid (UA) and is involved in the generation of reactive oxygen species (ROS). Overproduction of ROS has been linked to the pathogenesis of hypertension, atherosclerosis, and cardiovascular disease, with multiple studies over the last 30 years demonstrating that ...
Rajat Mudgal, Sanjiv Singh
openaire +3 more sources
Mechanisms of Action of Malondialdehyde and 4-Hydroxynonenal on Xanthine Oxidoreductase
Archives of Biochemistry and Biophysics, 2001 Studies have been made on the possible involvement of malondialdehyde (MDA) and (E)-4-hydroxynon-2-enal (HNE), two terminal compounds of lipid peroxidation, in modifying xanthine oxidoreductase activity through interaction with the oxidase (XO) and/or dehydrogenase (XDH) forms.
G. Cighetti +3 more
openaire +4 more sources
Journal of applied physiology, 2022
Excess activation of circulating xanthine oxidoreductase (XOR) may contribute to the pathogenesis of widespread remote organ injury, including kidney injury.
Keisei Kosaki +10 more
semanticscholar +1 more source
Excess activation of circulating xanthine oxidoreductase (XOR) may contribute to the pathogenesis of widespread remote organ injury, including kidney injury.
Keisei Kosaki +10 more
semanticscholar +1 more source
Regulation of xanthine oxidoreductase by intracellular iron
American Journal of Physiology-Cell Physiology, 2002Xanthine oxidoreductase (XOR) may produce reactive oxygen species and play a role in ischemia-reperfusion injury. Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression.
Eeva, Martelin +2 more
openaire +2 more sources
Enzymes Indigenous to Milk: Xanthine Oxidoreductase
2022Milk xanthine oxidase (XO) plays a first-line immune defense role in the mouth and gut of neonatal mammals, before their adaptive immune system develops. XO generates hydrogen peroxide, which is then utilized by lactoperoxidase to produce a range of powerful free radicals that have bactericidal and bacteriostatic effects, including against ...
Zhengzheng Zou +3 more
openaire +2 more sources
Xanthine oxidoreductase in respiratory and cardiovascular disorders
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension.
Adel, Boueiz +2 more
openaire +2 more sources
International Journal of Molecular Sciences, 2012 Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O2.
Kimiyoshi Ichida +2 more
exaly +2 more sources
Bioorganic chemistry (Print), 2022
Xanthine oxidoreductase (XOR) is a clinically validated target for the treatment of hyperuricemia and gout. A series of novel 1,2,4-triazoles were identified as potent XO inhibitors via a fused-pharmacophore strategy based on the interaction modes of ...
Yajun Yang +10 more
semanticscholar +1 more source
Xanthine oxidoreductase (XOR) is a clinically validated target for the treatment of hyperuricemia and gout. A series of novel 1,2,4-triazoles were identified as potent XO inhibitors via a fused-pharmacophore strategy based on the interaction modes of ...
Yajun Yang +10 more
semanticscholar +1 more source
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.
American Journal of Physiology. Endocrinology and Metabolism, 2020Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism
M. Furuhashi
semanticscholar +1 more source