Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases [PDF]
AntioxidantsNon-communicable neurological disorders are the second leading cause of death, and their burden continues to increase as the world population grows and ages.
Massimo Bortolotti +3 more
doaj +2 more sources
Xanthine oxidoreductase activity in platelet-poor and rich plasma as a oxidative stress indicator in patients required renal replacement therapy [PDF]
BMC Nephrology, 2022 Background Xanthine oxidoreductase (XOR) is a hydroxylase enzyme involved in the metabolism of purines. XOR activity can vary: the homodimer protein can be converted into two different isoforms XD (antioxidant) and XO (prooxidant).
Elżbieta Cecerska-Heryć +7 more
doaj +2 more sources
Xanthine Oxidoreductase‐Derived Reactive Species: Physiological and Pathological Effects [PDF]
Oxidative Medicine and Cellular Longevity, 2015 Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. In addition to this housekeeping function, mammalian XOR is a physiological source of superoxide ion, hydrogen peroxide, and nitric oxide, which can function as second messengers in the ...
Maria Giulia Battelli +3 more
openalex +3 more sources
Xanthine Oxidoreductase Function Contributes to Normal Wound Healing [PDF]
Molecular Medicine, 2015 Chronic, nonhealing wounds result in patient morbidity and disability. Reactive oxygen species (ROS) and nitric oxide (NO) are both required for normal wound repair, and derangements of these result in impaired healing. Xanthine oxidoreductase (XOR) has the unique capacity to produce both ROS and NO.
Michael C. Madigan +8 more
openalex +3 more sources
Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase
Redox Biology, 2019 Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders.
Maria Giulia Battelli +2 more
exaly +3 more sources
The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age [PDF]
Redox BiologyBackground: Xanthine oxidoreductase (XOR) is a multi-functional enzyme that metabolises purines generating uric acid and generates reactive oxygen species. Both functions have been implicated in the pathogenesis of cardiovascular disease.
Nicki Dyson +14 more
doaj +2 more sources
PLoS ONE, 2017 Background and purposeXanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis.
Yuki Fujimura +9 more
doaj +2 more sources
Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease [PDF]
AntioxidantsXanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the kidneys.
Hunter W. Korsmo +2 more
doaj +2 more sources
Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression [PDF]
Frontiers in Immunology, 2022 ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang +9 more
doaj +2 more sources
Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyadox as revealed by docking and mutagenesis studies. [PDF]
PLoS ONE, 2013 Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N ...
Chigang Chen +7 more
doaj +3 more sources