Results 21 to 30 of about 14,865 (241)

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation [PDF]

Nature Communications, 2015
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
Annette Ives, Fabio Martinon, Thierry Roger   +2 more
exaly   +3 more sources

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy [PDF]

FEBS Open Bio, 2021
Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage.
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura   +13 more
doaj   +2 more sources

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase. [PDF]

J Biol Chem, 2023
Sekine M, Okamoto K, Pai EF, Nagata K, Ichida K, Hille R, Nishino T.   +6 more
europepmc   +3 more sources

Xanthine oxidoreductase inhibition ameliorates high glucose-induced glomerular endothelial injury by activating AMPK through the purine salvage pathway [PDF]

Scientific Reports
Xanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation of the AMP ...
Keum-Jin Yang, Hwajin Park, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong   +5 more
doaj   +2 more sources

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. [PDF]

Nutr Diabetes, 2021
Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H.   +6 more
europepmc   +3 more sources

Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment [PDF]

Journal of Diabetes Investigation, 2021
Aims/Introduction Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans.
Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Hirofumi Nagao, Takashi Nakamura, Seigo Akari, Takayo Murase, Naohiro Taya, Kazuo Omori, Akimitsu Miyake, Shiro Fukuda, Mitsuyoshi Takahara, Shunbun Kita, Naoto Katakami, Norikazu Maeda, Iichiro Shimomura   +15 more
doaj   +2 more sources

Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension

Redox Biology, 2016
Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO ...
Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Danielle A. Guimaraes, Sandra O. Conde Tella, Ana L. Furlan Blanco, Celio D. Angelis, Alan N. Schechter, Jose E. Tanus-Santos   +7 more
doaj   +2 more sources

Investigation of the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol: A Computational Study. [PDF]

J Chem Inf Model, 2023
Maghsoud Y, Dong C, Cisneros GA.
europepmc   +3 more sources

Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease. [PDF]

Nutrients, 2023
Shimizu M, Naito R, Sato A, Ishiwata S, Yatsu S, Shitara J, Matsumoto H, Murata A, Kato T, Suda S, Hiki M, Kuwabara M, Murase T, Nakamura T, Kasai T.   +14 more
europepmc   +3 more sources

Urate production by human heart [PDF]

, 1989
Xanthine oxidoreductase has been demonstrated in the heart of various species. However, its presence in human heart is still debated. In the literature, high to undetectable levels have been reported.
Bonnier, J.J.R.M. (Hans), Czarnecki, W. (Wlodzimierz), Huizer, T. (Tom), Jong, J.W. (Jan Willem) de, Nelson, J.A. (Arly), Serruys, P.W.J.C. (Patrick), Troquay, R. (Roel)   +6 more
core   +12 more sources