Results 161 to 170 of about 689,556 (183)

Targeting xanthine oxidoreductase reverses resistance to EGFR tyrosine kinase inhibitors in intrahepatic cholangiocarcinoma

Journal of Hepatology
Despite the overexpression and aberrant activation of epidermal growth factor receptor (EGFR) in intrahepatic cholangiocarcinoma (iCCA), the disease remains refractory to EGFR tyrosine kinase inhibitors (TKIs). Multiple clinical trials involving EGFR-targeting agents have been conducted; however, none have demonstrated clinically significant efficacy ...
Jianbo He, Minglu Zhang, Yuze Shi, Zetao Ji, Yijun Lu, Weiwei Yu, Fei Wang, Qifei Guan, Hongyao Yan, Guanghou Chen, Endi Zhang, Senlin Lian, Xiaohong Pu, Jinyao Zhang, Song Ge, Rundi Zhou, Jiahui Li, Pin Wang, Beicheng Sun, Zechuan Zhang   +19 more
openaire   +2 more sources

Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases

Hypertension Research, 2022
openaire   +2 more sources

The Clinical Landscape of HDAC Inhibitors

Medical Epigenetics, 2021
Arasu Ganesan
exaly  

Synthesis and Bioevaluation of 1-Phenylimidazole-4-Carboxylic Acid Derivatives as Novel Xanthine Oxidoreductase Inhibitors

European Journal of Medicinal Chemistry, 2020
Xiaolei Li, Jing Li
exaly  

Histone Deacetylase Inhibitors in Medical Therapeutics

Medical Epigenetics, 2021
exaly  

Molecular Modelling Studies of 3,5-Dipyridyl-1,2,4-Triazole Derivatives as Xanthine Oxidoreductase Inhibitors Using 3D-QSAR, Topomer CoMFA, Molecular Docking and Molecular Dynamic Simulations

Journal of the Taiwan Institute of Chemical Engineers, 2016
Hong-Jin Tang, Jia-Huang Li
exaly  

Synthesis and Bioevaluation of 1-Phenyl-Pyrazole-4-Carboxylic Acid Derivatives as Potent Xanthine Oxidoreductase Inhibitors

European Journal of Medicinal Chemistry, 2017
Zheng Li, Huixiong Chen, Lei ZHANG
exaly  

In Silico Study of Febuxostat Analogs as Inhibitors of Xanthine Oxidoreductase: A Combined 3D-QSAR and Molecular Docking Study

Journal of Molecular Structure, 2019
Xiaolei Li, Jing Li
exaly  

Renoprotective Effect of the Xanthine Oxidoreductase Inhibitor Topiroxostat Under Decreased Angiotensin II Type 1a Receptor Expression

European Journal of Pharmacology, 2017
Atsuko Kamijo-Ikemori, Yugo Shibagaki, Keiichi Ohata   +2 more
exaly  

Discovery of 3-(3-Cyano-4-Pyridyl)-5-(4-Pyridyl)-1,2,4-Triazole, FYX-051-a Xanthine Oxidoreductase Inhibitor for the Treatment of Hyperuricemia

Bioorganic and Medicinal Chemistry Letters, 2009
Naoki Ashizawa, Osamu Nagata
exaly