Results 131 to 140 of about 44,980 (368)

METHYL XANTHINES, ADENOSINE 3′,5′‐CYCLIC MONOPHOSPHATE AND THE SPINAL TRANSMISSION OF NOCICEPTIVE INFORMATION

British Journal of Pharmacology, 1979
1 In spinal cats anaesthetized with either α‐chloralose or sodium pentobarbitone, a study was made of the effects of adenosine 3′,5′‐cyclic monophosphate (cyclic AMP), mono‐ and di‐butyryl cyclic AMP and the methyl xanthines, theophylline and isobutyl ...
A. W. Duggan, B. T. Griersmith
semanticscholar   +1 more source

Edible films as oral delivery systems for xanthines extracted from medicinal plants: an experimental design approach [PDF]

, 2016
Two formulations of edible films intended for oral delivery of therapeutic xanthines were developed, following an experimental design approach. Gelatin type A and sodium carboxymethylcellulose were used as polymeric matrices with different physico ...
Castro, Pedro M., Fonte, Pedro, Madureira, Ana Raquel, Oliveira, Ana, Pintado, Manuela, Sarmento, Bruno   +5 more
core  

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Collaborative Expert LLMs Guided Multi-Objective Molecular Optimization [PDF]

arXiv
Molecular optimization is a crucial yet complex and time-intensive process that often acts as a bottleneck for drug development. Traditional methods rely heavily on trial and error, making multi-objective optimization both time-consuming and resource-intensive. Current AI-based methods have shown limited success in handling multi-objective optimization
arxiv  

XANTHINE OXIDASE ACTIVITY IN REGENERATING LIVER [PDF]

, 1957
Muriel Feigelson, Philip Feigelson, Paul R. Gross   +2 more
openalex   +1 more source

Novel machine‐learning bioinformatics reveal distinct metabolic alterations for enhanced colorectal cancer diagnosis and monitoring

iMetaOmics, EarlyView.
The PANDA pipeline for colorectal cancer (CRC) analysis integrates metabolomic data from LC‐MS with machine learning techniques to classify CRC stages and predict biomarkers. Initially, the raw metabolomic data is processed using partial least squares discriminant analysis (PLS‐DA) to reduce dimensionality and highlight key features.
Rui Xu, Hyein Jung, Fouad Choueiry, Shiqi Zhang, Rachel Pearlman, Heather Hampel, Ning Jin, Jieli Li, Jiangjiang Zhu   +8 more
wiley   +1 more source

Design and Synthesis of New A2B Adenosine Receptor Antagonists [PDF]

, 2009
Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B ...
BARALDI, Stefania
core  

Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females

iMetaOmics, EarlyView.
Researchers recruited 623 participants, including 270 females, and used 16S rDNA sequencing to investigate gender differences in hyperuricemia. In healthy females, Roseburia was enriched, positively correlating with estrogen and negatively with uric acid, suggesting it is a potential biomarker affecting uric acid levels in females.
Zhihan Yang, Zeng Zhang, Mohan Chen, Jin Hu, Yingqi Qiu, Shijia Lin, Xiaolu Zhou, Jiachao Zhang, Shuaiming Jiang   +8 more
wiley   +1 more source

Ueber das Xanthin [PDF]

Justus Liebigs Annalen der Chemie
n ...
openaire   +6 more sources

Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment

Interdisciplinary Medicine, EarlyView.
In this work, we introduce a novel composite microneedle (MN) patch that integrates ruthenium‐loaded magnesium silicate nanosheets (MSR) as a multifaceted therapeutic platform with oxidative stress mitigation, ROS generation inhibition and cellular signaling pathways restoration for treating RISD.
Zhongyi Sun, Haibo Liu, Mengting Yin, Ningning Cheng, Wencheng Liu, Kangkang Zhao, Hua Zeng, Xuming Chen, Zijie Wang, Xuhui Zhou, Xinyu Zhao, Feng Chen   +11 more
wiley   +1 more source