Results 161 to 170 of about 44,980 (368)

The chemistry of xanthine oxidase. 5. Electron-spin resonance of xanthine oxidase solutions [PDF]

, 1959
Robert C. Bray, Bo G. Malmström, Tore Vänngård   +2 more
openalex   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Further Studies with Xanthine Oxidase Inhibitors

, 1959
W.W. Westerfeld, Dan A. Richert, Edwin S. Higgins   +2 more
openalex   +1 more source

Studies on xanthine oxidase [PDF]

Biochemical Journal, 1934
David Ezra Green, Malcolm Dixon
openaire   +3 more sources

Purinergic signalling: past, present and future [PDF]

, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
Burnstock, G
core   +1 more source

Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease

Brain Pathology, Volume 35, Issue 3, May 2025.
Aerobic exercise improves transfer of healthy mitochondria from astrocytes to neurons in the 5 × FAD mice. Abstract Mitochondrial dysfunction is a well‐established hallmark of Alzheimer's disease (AD). Despite recent documentation of transcellular mitochondrial transfer, its role in the pathogenesis of AD remains unclear.
Jiachen Cai, Yan Chen, Yuzhu She, Xiaoxin He, Hu Feng, Huaiqing Sun, Mengmei Yin, Junying Gao, Chengyu Sheng, Qian Li, Ming Xiao   +10 more
wiley   +1 more source

Steps in the oxidation of xanthine to uric acid catalysed by milk xanthine oxidase [PDF]

, 1959
H. Gutfreund, Julian M. Sturtevant
openalex   +1 more source

PRS16 The Budget Impact Of Duoresp® Spiromax® Compared With Commonly Prescribed Dry Powder Inhalers For The Management Of Asthma And Chronic Obstructive Pulmonary Disease In Italy: Estimated Impact Of Inhalation Technique [PDF]

, 2015
Blackney, M, Bruno, GM, Burgio, L, Colombo, GL, Di Matteo, S, di Nola, L, Lewis, A, Nicolai, J, Plich, A, Pulimeno, S, Torvinen, S, Valentino, MC   +11 more
core   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

NOTES ON THE QUANTITATIVE DETERMINATION OF XANTHINES AND URIC ACIDS IN PLASMA

, 1958
Felix Bergmann, S. Dikstein, Moshe Chaimovitz   +2 more
openalex   +1 more source