Results 161 to 170 of about 6,368 (267)

Potential of doxofylline in the treatment of chronic obstructive airway diseases (Review). [PDF]

Biomed Rep
Covantsev S, Poparcea D, Bumbu A, Ceasovschih A, Georgakopoulou VE, Spandidos DA, Corlateanu A.   +6 more
europepmc   +1 more source

Daidzein Ameliorate Hyperuricemia by Upregulating ABCG2 Expression via Activation of PPARγ and PI3K/AKT Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
Hyperuricaemia is a chronic metabolic disorder arising from impaired purine metabolism, exhibiting marked gender disparities in its prevalence. Daidzein, possessing oestrogen‐like effects, promotes uric acid excretion and improves hepatic and renal function, thereby presenting potential utility as an adjunctive therapeutic agent for hyperuricaemia ...
Zicheng Zhu, Jujie Pan, Ruixia Bao, Beibei Chen, Siyi Li, Ziyu Che, Qian Chen, Yuzheng Wu, Dan Wang, Tao Wang   +9 more
wiley   +1 more source

Unveiling of phosphodiesterase-5 hot residues binding to xanthine derivatives for erectile dysfunction therapy: A computational drug repurposing approach. [PDF]

PLoS One
Elzupir AO, Almahmoud SAJ.
europepmc   +1 more source

Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress

Advanced Genetics, Volume 7, Issue 1, March 2026.
Mechanical stress‐induced oxidative stress is a universal challenge across species, triggering a conserved antioxidant defense strategy. This perspective delves into the molecular evolutionary logic of this response, comparing mechanisms across plants, microorganisms, and animals to reveal their profound phylogenetic significance.
Feixiang Zhu, Kai Huang
wiley   +1 more source

Trends in initial pharmacological COPD treatment in primary care (2010-2021): a population-based study using the PHARMO Data Network. [PDF]

Respir Res
Rodrigues G, Antão J, Deng Q, Baak BN, Marques A, Franssen FME, Spruit MA.   +6 more
europepmc   +1 more source

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Pulmonary hypertension (PH) is a severe vascular complication of sickle cell disease (SCD); yet, not all patients with SCD develop PH, and PH also arises independently. This duality underscores the need to understand their intersecting biology.
Francesca I. Cendali, Christina Lisk, Amy Argabright, Monika Dzieciatkowska, Nishant K. Rana, Delaney Swindle, Daniel Stephenson, Julie McAfee, Natalie Westover, Melissa Lucero, Aneta Gandjeva, Kurt Stenmark, Rubin Tuder, Brian B. Graham, Tim Lahm, Vijaya Karoor, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Pavel Davizon‐Castillio, Paul W. Buehler, Angelo D'Alessandro, David C. Irwin   +22 more
wiley   +1 more source

Development of subtype-selective covalent ligands for the adenosine A_2B receptor by tuning the reactive group. [PDF]

RSC Med Chem, 2022
Beerkens BLH, Wang X, Avgeropoulou M, Adistia LN, van Veldhoven JPD, Jespers W, Liu R, Heitman LH, IJzerman AP, van der Es D.   +9 more
europepmc   +1 more source

Methylene Blue Administration Reduces Acute Kidney Injury After Living Donor Liver Transplantation: A Single‐Center Retrospective Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The efficacy of methylene blue (MB) in preventing acute kidney injury (AKI) in liver transplant recipients remains unclear. In this study, we hypothesized that pre‐reperfusion administration of MB decreases the incidence of postoperative AKI in living donor liver transplantation (LDLT).
Akira Katayama, Ezeldeen Abuelkasem, Yaroslava Longhitano, Raymond M. Planinsic, Austin C. Smith, David W. Wang   +5 more
wiley   +1 more source

Faecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas. [PDF]

Int J Mol Sci
Valdés A, Ruiz-Saavedra S, Salazar N, Cifuentes A, Suárez A, Díaz Y, Del Rey CG, González S, de Los Reyes-Gavilán CG.   +8 more
europepmc   +1 more source

The gut microbiome promotes the growth performance of black soldier fly larvae by detoxifying uric acid

iMetaOmics, Volume 3, Issue 1, March 2026.
This study demonstrates the detrimental effects of exogenous uric acid (UA) on the growth of black soldier fly (BSF) larvae, highlighting the role of gut microbiota in UA degradation. We isolated UA‐degrading bacterial strains associated with BSF, including Enterococcus faecalis AHAU24.
Xiaowen Ji, Shaojie Zhou, Wenwen Chen, Bin Cao, Jingjing Zhuang, Sheng Zhang, Bingshuo Han, Benping Yang, Shuxiang Zhang, Yanfeng Xue, Jibin Zhang, Yinglao Zhang, Wei Liu   +12 more
wiley   +1 more source