Results 211 to 220 of about 4,011 (296)

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Investigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial - ICONICplus Trial. [PDF]

BMJ Open
Vetter S, Weinberg J, Thomas BC, Kirchner M, Thalmann P, Klose C, Pfisterer M, Kölsch T, Oesterle S, Vollstaedt-Klein S, Koopmann A, Lenz B, Kiefer F, Link T, Bach P.   +14 more
europepmc   +1 more source

Xanthin [PDF]

, 2017
openaire   +2 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Chemical Profiling and In Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian Erica arborea L. Extracts, Strengthened by Molecular Modeling Analysis

ChemistryOpen, Volume 15, Issue 8, August 2026.
Erica arborea L. from Algeria was valorized via chemical profiling and bioactivity assessment. The EtOAc extract showed the highest levels of polyphenols, flavonoids, and flavonols. It exhibited strong antioxidant (ABTS•+, DPPH•, FRAP) and antibacterial activity (S. aureus, B. subtilis).
Amina Bramki, Ouided Benslama, Fatima Zohra Makhlouf, Anna Andolfi, Zineb Mokhbi, Selsabile Nedjaoum, Chawki Bensouici, Maria Michela Salvatore, Marco Masi   +8 more
wiley   +1 more source

Chromatographic Profiling of Artisanal Chocolates: Volatile Composition and Methylxanthines as Markers of Cocoa Content. [PDF]

J Food Sci
Altissimo J, Cardoso I, Araújo BQ, Pereira AR, Almeida JVM, Santos NAD, Costa VC, Carneiro Lima MTWD.   +7 more
europepmc   +1 more source

Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
We developed a GalNAc‐conjugated siRNA targeting hepatic XDH, which effectively reduces uric acid production by silencing XDH expression, offering a promising therapeutic approach for hyperuricemia. ABSTRACT Hyperuricemia (HUA) is primarily driven by hepatic overproduction of urate, mediated by xanthine dehydrogenase (XDH).
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui   +12 more
wiley   +1 more source

Coffee Silverskin Supplementation Alleviates High-Glucose-Diet-Induced Obesity by Modulating Lipogenic Gene Expression in <i>Caenorhabditis elegans</i> Model. [PDF]

Molecules
Schifano E, Zinno P, Natella F, Pompa L, Sonaglia E, Spaziani S, Sharbaf M, Esposito F, Cirillo T, Squillante J, Maglione G, Mancini P, Angeloni A, Santarelli ML, Devirgiliis C, Uccelletti D.   +15 more
europepmc   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Photoelectrochemical Iron(III) Catalysis for Late-Stage C─H Fluoroalkylations. [PDF]

Angew Chem Int Ed Engl
Motornov V, Trienes S, Resta S, Oliveira JCA, Lin Z, Liu Z, von Münchow T, Stückl C, Ackermann L.   +8 more
europepmc   +1 more source