Results 221 to 230 of about 4,011 (296)

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

DAMPs cross-talk interpretation of MDD mechanisms. [PDF]

Sci Adv
Peng Y, Chen Z, Xu Y, Ren B.
europepmc   +1 more source

Effects of Coffee Decaffeination on Beverage Bioactives, Antioxidant Activity, and Lipid Metabolism in Hyperlipidemic Rats

Journal of Food Science, Volume 91, Issue 8, August 2026.
ABSTRACT The aim of this study was to evaluate the effect of chemical decaffeination on two coffee species (Coffea arabica and Coffea canephora) in terms of the chemical composition of filtered coffee beverages and their influence on lipid profile and oxidative stress in rats with diet‐induced hyperlipidemia. Rats (n = 30) were divided into six groups:
Adriene Ribeiro Lima, Jeniffer Ferreira de Miranda, Juliana Mesquita Freire, Paula Kujbida, Sheila Andrade Abrahão, Eulália Mendes, José Avelino Alves Andrade da Silva, Fernanda Borges de Araújo Paula, Stella Maris da Silveira Duarte, Rosemary Gualberto Fonseca Alvarenga Pereira, Susana Casal   +10 more
wiley   +1 more source

Comprehensive blood metabolomics profiling of Parkinson's disease reveals coordinated alterations in xanthine metabolism. [PDF]

NPJ Parkinsons Dis
de Lope EG, Loo RTJ, Rauschenberger A, Ali M, Pavelka L, Marques TM, Gomes CPC, Krüger R, Glaab E, NCER-PD Consortium.   +9 more
europepmc   +1 more source

Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis

Aging Cell, Volume 25, Issue 8, August 2026.
Hydra oligactis undergoes cold‐induced sexual differentiation and aging, culminating in death. GC–MS‐based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulation, and of aging, such as loss of cytoprotection and neurotransmitter function, including taurine depletion.
Nicki Marami‐Zonouz, Erwann Arc, Thomas Roach, Pidder Jansen‐Dürr, Werner Bader, Bert Hobmayer, Ilse Kranner   +6 more
wiley   +1 more source

A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes. [PDF]

Proc Natl Acad Sci U S A
Wu Z, Liu L, Han W, Cai X, Xiao P, Sun Z, Yan C, Reid S, Chen Y, Ma Z, Tang Y, Jacobsen SE.   +11 more
europepmc   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, Volume 209, Issue 2, Page 420-431, August 2026.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Consensus of Korean Asthma Study Group on Definition of Clinical Remission in Severe Asthma: A Modified Delphi Study. [PDF]

Tuberc Respir Dis (Seoul)
Shin SH, Choi JY, Yoon J, Kim Y, Jang JG, Moon JY, Rhee CK, Min KH, Hwang YI, Oh YM, Lim SY.   +10 more
europepmc   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source