Results 251 to 260 of about 44,980 (368)

PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Leukopenia is a common dose‐dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine‐induced leukopenia but only explain 25% of cases. Thus, we aimed to identify novel genetic risk factors among TPMT and NUDT15 normal metabolizers through a genome‐wide ...
Laura L. Daniel, Puran Nepal, Jacy Zanussi, Alyson L. Dickson, Peter Straub, Tyne W. Miller‐Fleming, Wei‐Qi Wei, Adriana M. Hung, Nancy J. Cox, Vivian K. Kawai, Jonathan D. Mosley, Charles Michael Stein, QiPing Feng, Ge Liu, Ran Tao, Cecilia P. Chung   +15 more
wiley   +1 more source

Comprehensive blood metabolomics profiling of Parkinson's disease reveals coordinated alterations in xanthine metabolism. [PDF]

NPJ Parkinsons Dis
de Lope EG, Loo RTJ, Rauschenberger A, Ali M, Pavelka L, Marques TM, Gomes CPC, Krüger R, Glaab E, NCER-PD Consortium.   +9 more
europepmc   +1 more source

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source

Studies on Xanthine and Related Compounds. IV

, 1960
Yoshiro Ozaki
openalex   +2 more sources

An Enzymatic Spectrophotometric Method for the Determination of Xanthine and Hypoxanthine [PDF]

, 1967
James R. Klinenberg, Stephen E. Goldfinger, Kathryn H. Bradley, J. Edwin Seegmiller   +3 more
openalex   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Methylxanthine use in infants with hypoxic-ischemic encephalopathy: a retrospective cohort study. [PDF]

Sci Rep
Laughon ME, Johnson JK, Greenberg RG, Clark RH, Jackson WM.   +4 more
europepmc   +1 more source

Purification and Properties of Chicken Liver Xanthine Dehydrogenase

, 1967
K.V. Rajagopalan, Philip Handler
openalex   +1 more source

Liver xanthine oxidase [PDF]

Biochemical Journal, 1936
openaire   +3 more sources

Biomarkers in heart failure: Traditional and emerging indicators for prognosis

ESC Heart Failure, Volume 12, Issue 3, Page 1535-1538, June 2025.
Arnold Péter Ráduly, László Nagy, Beáta Bódi, Zoltán Papp, Attila Borbély   +4 more
wiley   +1 more source