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Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential

Anti-Cancer Agents in Medicinal Chemistry, 2022
Abstract: The overwhelming globalburden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicalshave emerged as promising synergistic compounds with potential anti-cancer effects to supplement chemo- and immune-therapeutic regimens.
Hardeep S. Tuli   +9 more
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Anticoccidial Effects of Xanthohumol

Avian Diseases Digest, 2007
Xanthohumol (XN), a prenylated chalcone from the hops flower, was examined for its ability to reduce invasion of Madin-Darby bovine kidney (MDBK) cells by Eimeria tenella sporozoites (SZ), as well as to reduce invasion by E. tenella and E. acervulina SZ in the chick host.
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Inhibition of Suicidal Erythrocyte Death by Xanthohumol

Journal of Agricultural and Food Chemistry, 2009
Xanthohumol is a proapoptotic hop-derived beer component with anticancer and antimicrobial activities. Similar to nucleated cells, erythrocytes may undergo suicidal cell death or eryptosis, which is triggered by oxidative stress (tert-butylhydroperoxide, TBOOH) or energy depletion (removal of glucose).
Syed M, Qadri   +3 more
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Microbial Metabolism of the Prenylated Chalcone Xanthohumol

Journal of Natural Products, 2006
Microbial metabolism of xanthohumol (1), a prenylated chalcone isolated from hops, gave three novel glucosylated derivatives (2-4) and a known compound, isoxanthohumol (5). The structures of the new compounds were identified as xanthohumol 4'-O-beta-glucopyranoside (2), xanthohumol 4,4'-O-beta-diglucopyranoside (3), and 5-methoxy-8-prenylnaringenin 7-O-
Hyun Jung, Kim, Ik-Soo, Lee
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Triggering of dendritic cell apoptosis by xanthohumol

Molecular Nutrition & Food Research, 2010
AbstractXanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol further has anti‐inflammatory activity. However, little is known about the effect of xanthohumol on survival and function of immune cells.
Xuan, Nguyen Thi   +5 more
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On The Synthesis of Xanthohumol and Isoxanthohumol

Bulletin des Sociétés Chimiques Belges, 1961
AbstractThe structure of xanthohumol, a chalcone present in hops and isoxanthohumol, the corresponding flavanone, proved by us in previous papers are confirmed by further investigation.
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Xanthohumol, a New Natural Chalkone

Bulletin des Sociétés Chimiques Belges, 1957
AbstractXanthohumol is a yellow leaf pigment, present in all hop varieties. It is a chalkone and isomerizes into a flavanone on alkaline treatment. Xanthohumol has the molecular formula C21H22O3 contains three active hydrogen atoms, one methoxylgroup, one carbonylgroup and two double bonds. Alkaline hydrolysis of xanthohumol yields p.
M. Verzele   +3 more
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Re-evaluation of superoxide scavenging capacity of xanthohumol

Free Radical Research, 2010
The chemopreventive chalcone xanthohumol (Xh) has been reported to decrease xanthine oxidase (XOD) catalysed formation of formazan from nitroblue tetrazolium (NBT) and is discussed as a potent scavenger of superoxide. Re-evaluation of the scavenging capacity indicated that Xh disturbed detection of superoxide with NBT, in case of an insufficient NBT/Xh
Harald, Schempp   +3 more
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Zur Konstitution des Xanthohumols

Chemische Berichte, 1960
AbstractEs wird gezeigt, daß der aus Xanthohumol durch Alkali‐Abbau entstehende 2‐[γ.γ‐Dimethyl‐allyl]‐phloroglucin‐x‐methyläther mit dem 1‐Methyläther identisch sein dürfte. Die Synthese des Xanthohumol‐dimethyläthers (Kondensation von 3‐[γ.γ‐Dimethyl‐allyl]‐phloracetophenon‐4.6‐dimethyläther mit Anisaldehyd) steht in Einklang mit der Konstitution des
Herbert Hübner, Wolfgang Riedl
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Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives

Journal of Agricultural and Food Chemistry, 2015
Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene derivatives, obtained by chemical synthesis, were studied for antifeedant activity against the peach-potato aphid (Myzus persicae [Sulz.]).
Monika, Stompor   +3 more
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