Results 171 to 180 of about 5,446 (188)

Xenophagy: Autophagy in Direct Pathogen Elimination

2016
Autophagy is an intracellular catabolic pathway that delivers unwanted cytoplasmic materials to the lysosome for degradation. The degradative autophagy pathway has been shown to play essential roles not only in cellular homeostasis but also in cell-autonomous immune defense against invading pathogens. Recent data further showed that the contribution of
Eun-Kyeong Jo, Jin Kyung Kim, Seungmin Hwang   +2 more
openaire   +1 more source

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles

Cell Reports, 2019
Summary: The autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria. However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear. Here,
François-Xavier Campbell-Valois, Truc Losier, Subash Sàd   +2 more
exaly   +2 more sources

Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy

Cell Host & Microbe
Although pancreatic ductal adenocarcinoma (PDAC) tumors harbor unique intracellular bacteria, therapeutic strategies to harness them and overcome immunotherapy resistance remain elusive. Through 16S rDNA sequencing of PDAC tumors from 40 patients and screening of probiotic strains, we identified Bifidobacterium longum (B.
Baoyi Li, Guangnian Liu, Yu Zhu, Lin Chen, Nianhua Zhang, Xiaojuan Zhu, Yixin Sun, Xinxin Liu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang, Motao Zhu   +12 more
openaire   +2 more sources

Xenophagy in Helicobacter pylori‐ and Epstein–Barr virus‐induced gastric cancer

The Journal of Pathology, 2014
AbstractHelicobacter pylori and Epstein–Barr virus (EBV) account for roughly 80% and 10%, respectively, of gastric carcinomas worldwide. Autophagy is an evolutionarily conserved and intricately regulated cellular process that involves the sequestration of cytoplasmic proteins and organelles into double‐membrane autophagosomes that eventually fuse with ...
Lin, Zhang, Joseph J Y, Sung, Jun, Yu, Siew C, Ng, Sunny H, Wong, Chi H, Cho, Simon S M, Ng, Francis K L, Chan, William K K, Wu   +8 more
openaire   +2 more sources

Unraveling the Intricacies of Xenophagy: Lessons from Legionella pneumophila.

Journal of visualized experiments : JoVE
Autophagy, a conserved eukaryotic process for maintaining cellular homeostasis, plays a crucial role in innate immunity by targeting intracellular pathogens through selective autophagy, known as xenophagy. While xenophagy is vital for pathogen clearance, many intracellular bacteria have evolved sophisticated strategies to avoid or subvert this process.
Yuyang, Zhang, Zhenxiang, Yu, Yuanhui, Jin, Xiaowei, Tian   +3 more
openaire   +1 more source

Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival

Autophagy, 2022
Chengyuan Tang, Xiangmei Zhou, Yuhui Dong   +2 more
exaly  

High Levels of TRIM5α Are Associated with Xenophagy in HIV-1-Infected Long-Term Nonprogressors

Cells, 2021
Alessandra Vergori, Marco Corazzari
exaly  

FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan

EMBO Reports, 2021
Ichiro Nakagawa, Takashi Nozawa, Akihiro Yamada   +2 more
exaly  

Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy

Autophagy, 2020
Ravi Manjithaya, Piyush Mishra, Veena Ammanathan   +2 more
exaly  

Xenophagy as a Strategy for Mycobacterium leprae Elimination during Type 1 or Type 2 Leprosy Reactions: A Systematic Review

Pathogens, 2023
Matheus Fernandes, Souto Fo, Debora Cerqueira   +2 more
exaly