Results 161 to 170 of about 5,446 (188)
Microbial trash to metabolic treasure. [PDF]
Immunometabolism (Cobham)Dowdell AS, Colgan SP.
europepmc +1 more source
GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages. [PDF]
Cell Mol ImmunolYan Z +8 more
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Individual Atg8 paralogs exhibit unique properties in <i>streptococcus pneumoniae</i>-induced hierarchical autophagy. [PDF]
AutophagyShizukuishi S, Ogawa M, Akeda Y.
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LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy
LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagyopenaire +1 more source
A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy [PDF]
Cell, 2019 Antibacterial autophagy (xenophagy) is an important host defense, but how it is initiated is unclear. Here, we performed a bacterial transposon screen and identified a T3SS effector SopF that potently blocked Salmonella autophagy.
Yue Xu, Xiaoyun Liu, Jingjin Ding
exaly +5 more sources
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Seminars in Cancer Biology, 2020
Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stress, organelles and proteins not ...
Veena, Ammanathan +3 more
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Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stress, organelles and proteins not ...
Veena, Ammanathan +3 more
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Xenophagy in innate immunity: A battle between host and pathogen
Developmental and Comparative Immunology, 2020Autophagy is a fundamental bulk intracellular degradation and recycling process that directly eliminates intracellular microorganisms through "xenophagy" in various types of cells, especially in macrophages. Meanwhile, bacteria have evolved strategies and cellular self-defense mechanisms to prevent autophagosomal degradation and even attack the immune ...
Chenghua Li
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The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes [PDF]
Autophagy, 2017 Macroautophagy/autophagy plays a critical role in immunity by directly degrading invading pathogens such as Group A Streptococcus (GAS), through a process that has been named xenophagy. We previously demonstrated that autophagic vacuoles directed against
Ichiro Nakagawa +2 more
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Tug of War in the Xenophagy World
Trends in Cell Biology, 2019Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF, to identify a SopF-sensitive ...
Kuan Chuan, Pao, Michael, Rape
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The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy
2023Autophagy is a physiological response, activated by a myriad of endogenous and exogenous cues, including DNA damage, perturbation of proteostasis, depletion of nutrients or oxygen and pathogen infection. Upon sensing those stimuli, cells employ multiple non-selective and selective autophagy pathways to promote fitness and survival.
Rubio-Tomás, Teresa +2 more
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