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Recent progress in pig-to-human kidney xenotransplantation [PDF]
Frontiers in ImmunologyEven though the patient kept up his dialysis regimen as he had before xenotransplantation, this is a significant development for xenotransplantation. This benchmark for xenotransplantation has the following significant findings. Firstly, from the patient’
Pei Tao, Pei Tao, Kaiyu Zhou
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Clinical xenotransplantation [PDF]
Xenotransplantation, 1994 : Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies ...
Bailey +16 more
core +5 more sources
The Future of Pig Liver Xenotransplantation [PDF]
Transplant InternationalRecent technological advances in genetic engineering have led to a renewed interest in xenotransplantation. Milestones achievements in heart, kidney and more recently liver xenotransplantation raise the hope of an alternative source of organs and pave ...
Ahmad Karadagi +3 more
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British Medical Bulletin, 1999 The success of organ transplantation has led to an ever-increasing shortfall between the demand for organs and the supply. This has led to extensive investigation of the possible use of animals, especially the pig, as organ donors. However, a number of major barriers to successful xenotransplantation exist.
L H, McBride +3 more
+10 more sources
Nature Biotechnology, 2019 One of the leading causes of death is organ failure, that is, when one or other of the organs that run the machine we call the body gives out. However, whereas with a machine, spare parts can usually replace faulty parts, in the case of humans the supply of these is limited as it is dependent on organs being obtained from living or dead donors.
Syed Tausif Ahmed, Vivek Dubey
+6 more sources
Life, 2021 The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li +13 more
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Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Life, 2022 As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang +19 more
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Current Opinion in Nephrology and Hypertension, 1996 Xenotransplantation of pig organs into humans represents an attractive solution to the worldwide organ shortage. The survival of pig organs in primates has so far primarily been hampered by hyperacute rejection of the xenograft. The immunological mechanisms which underlie hyperacute rejection have recently been clarified.
Cozzi E., White D. J. G.
+7 more sources
Cells, 2022 A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and ...
Lihua Zhao +13 more
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Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Frontiers in Veterinary Science, 2022 Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu +43 more
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