Results 1 to 10 of about 29,864 (273)
Journal of Transplant Coordination, 1999 Xenotransplantation is a potentially promising but exceedingly complex issue. It is critical that this subject be discussed within and outside the transplant community. The need for an expanded organ supply is urgent, but the scientific and ethical positions are complex.
L H, McBride +3 more
+10 more sources
Donor pigs for clinical islet xenotransplantation: Review and future directions. [PDF]
Cell TransplantAllogeneic islet transplantation becomes a viable option for patients with unstable type 1 diabetes. However, considering the huge number of patients with type 1 diabetes, human donor shortage is a serious issue.
Matsumoto S +5 more
europepmc +2 more sources
Life, 2021 The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li +13 more
doaj +1 more source
Organogenesis, 2018 The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood.
Srijan, Tandukar, Sundaram, Hariharan
openaire +5 more sources
Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Life, 2022 As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang +19 more
doaj +1 more source
Cells, 2022 A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and ...
Lihua Zhao +13 more
doaj +1 more source
Current Opinion in Nephrology and Hypertension, 1996 Xenotransplantation of pig organs into humans represents an attractive solution to the worldwide organ shortage. The survival of pig organs in primates has so far primarily been hampered by hyperacute rejection of the xenograft. The immunological mechanisms which underlie hyperacute rejection have recently been clarified.
Cozzi E., White D. J. G.
openaire +4 more sources
Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan
Veterinary Sciences, 2022 Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal +12 more
doaj +1 more source
Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Frontiers in Veterinary Science, 2022 Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu +43 more
doaj +1 more source
陆军军医大学学报, 2022 Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi +5 more
doaj +1 more source