Results 11 to 20 of about 14,529 (159)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Establishment of PIN1 knockout porcine fetal fibroblast cell lines via CRISPR/Cas9 mediated gene-targeting

陆军军医大学学报, 2022
Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi, YUAN Yilin, LI Lin, WANG Ying, DAI Yifan, YANG Haiyuan   +5 more
doaj   +1 more source

AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Cell & Bioscience, 2023
Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue   +12 more
doaj   +1 more source

Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

Frontiers in Immunology, 2022
Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao, Heng Zhao, Heng Zhao, Weijian Ye, Weijian Ye, Jianxiong Guo, Jianxiong Guo, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Deling Jiao, Deling Jiao, Deling Jiao, Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Chang Yang, Chang Yang, Shuhan Chen, Shuhan Chen, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Taiyun Wei, Jie Cai, Jie Cai, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Yubo Qing, Yubo Qing, Yubo Qing, Wenmin Cheng, Wenmin Cheng, Wenmin Cheng, Baoyu Jia, Baoyu Jia, Baoyu Jia, Honghui Li, Honghui Li, Honghui Li, Hong-Ye Zhao, Hong-Ye Zhao, Qingfeng Chen, Qingfeng Chen, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +49 more
doaj   +1 more source

Xenotransplantation [PDF]

Organogenesis, 2018
The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood.
Srijan, Tandukar, Sundaram, Hariharan
openaire   +2 more sources

Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

Laboratory Animal Research, 2021
Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
doaj   +1 more source

Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2023
The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs).
Meng Zhou, Manling Zhang, Tianxu Guo, Lihua Zhao, Lihua Zhao, Xiyun Guo, Zhibao Yin, Linxin Cheng, Han Liu, Lixia Zhao, Xihe Li, Rongfeng Li, Rongfeng Li   +12 more
doaj   +1 more source

Xenotransplantation

Journal of British Surgery, 2000
Abstract Background The success of clinical transplantation has led to a large discrepancy between donor organ availability and demand; considerable pressure exists to develop an alternative source of organs.
Soin, B, Vial, C, Friend, P
openaire   +5 more sources

Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Disease Models & Mechanisms, 2018
Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans.
Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai   +19 more
doaj   +1 more source

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Transplantation Direct, 2020
Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies
Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD   +7 more
doaj   +1 more source