Results 11 to 20 of about 29,864 (273)

Xenotransplantation [PDF]

Journal of British Surgery, 2000
Abstract Background The success of clinical transplantation has led to a large discrepancy between donor organ availability and demand; considerable pressure exists to develop an alternative source of organs.
Soin, B, Vial, C, Friend, P
openaire   +4 more sources

Xenotransplantation: Current Status in Preclinical Research

Frontiers in Immunology, 2020
The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between ...
Tianyu Lu, Tianyu Lu, Tianyu Lu, Bochao Yang, Bochao Yang, Bochao Yang, Ruolin Wang, Ruolin Wang, Ruolin Wang, Chuan Qin, Chuan Qin, Chuan Qin   +11 more
doaj   +2 more sources

Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation

Frontiers in Immunology, 2022
Organ transplantation is the most effective treatment for end stage organ failure, but there are not enough organs to meet burgeoning demand. One potential solution to this organ shortage is xenotransplantation using pig tissues.
Daniel L. Eisenson, Daniel L. Eisenson, Yu Hisadome, Kazuhiko Yamada, Kazuhiko Yamada   +4 more
doaj   +2 more sources

Infection in xenotransplantation

BMJ, 2000
Advances in transplantation immunology have enhanced the possibility of xenotransplantation as a therapeutic option for end-stage organ failure. The potential spread of animal-derived pathogens to the recipient and to the general population, termed "xenosis," is a potential complication of interspecies transplantation.
J. A. Fishman
openaire   +6 more sources

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.

New England Journal of Medicine, 2022
A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically ...
B. Griffith, C. Goerlich, Avneesh K. Singh, M. Rothblatt, C. Lau, Aakash M. Shah, M. Lorber, A. Grazioli, K. Saharia, Susie N. Hong, Susan Joseph, D. Ayares, M. Mohiuddin   +12 more
semanticscholar   +1 more source

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation.

New England Journal of Medicine, 2022
BACKGROUND Xenografts from genetically modified pigs have become one of the most promising solutions to the dearth of human organs available for transplantation. The challenge in this model has been hyperacute rejection.
R. Montgomery, J. Stern, B. Lonze, V. Tatapudi, M. Mangiola, Ming-Hsiou Wu, E. Weldon, Nikki Lawson, Cecilia L. Deterville, Rebecca A. Dieter, Brigitte Sullivan, Gabriella Boulton, Brendan Parent, G. Piper, Philip M. Sommer, Samantha Cawthon, E. Duggan, D. Ayares, A. Dandro, A. Fazio-Kroll, M. Kokkinaki, L. Burdorf, M. Lorber, J. Boeke, H. Pass, B. Keating, A. Griesemer, N. Ali, S. Mehta, Z. Stewart   +29 more
semanticscholar   +1 more source

From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation

Frontiers in Bioengineering and Biotechnology, 2023
Slaughterhouses produce large quantities of biological waste, and most of these materials are underutilized. In many published reports, the possibility of repurposing this form of waste to create biomaterials, fertilizers, biogas, and feeds has been ...
Ryan Basith Fasih Khan, A. Khraibi, L. Dumée, Peter R. Corridon   +3 more
semanticscholar   +1 more source

Xenotransplantation: Current Challenges and Emerging Solutions

Cell Transplantation, 2023
To address the ongoing shortage of organs available for replacement, xenotransplantation of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing xenotransplants is rejection due to a cycle of immune reactions to the ...
T. Arabi, B. Sabbah, A. Lerman, Xiang-Yang Zhu, L. Lerman   +4 more
semanticscholar   +1 more source

Genetically engineered pigs for xenotransplantation: Hopes and challenges

Frontiers in Cell and Developmental Biology, 2023
The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi, Wei Zheng, Min Chen, Qingjian Zou, Chengcheng Tang, Xiaoqing Zhou   +5 more
semanticscholar   +1 more source

The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation

Xenotransplantation, 2023
The mechanistic/mammalian target of rapamycin (mTOR) is one of the systems that are necessary to maintain cell homeostasis, such as survival, proliferation, and differentiation. mTOR inhibitors (mTOR‐Is) are utilized as immunosuppressants and anti‐cancer
A. Maenaka, Kohei Kinoshita, H. Hara, D. Cooper   +3 more
semanticscholar   +1 more source