Results 21 to 30 of about 14,529 (159)

Kidney xenotransplantation [PDF]

Kidney International, 2014
Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process ...
Cowan, PJ, Cooper, DKC, d'Apice, AJF
openaire   +3 more sources

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
doaj   +1 more source

The history of cardiac xenotransplantation: early attempts, major advances, and current progress

Frontiers in Transplantation, 2023
In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch.
Nicholas R. Hess, David J. Kaczorowski, David J. Kaczorowski   +2 more
doaj   +1 more source

Clinical xenotransplantation [PDF]

Xenotransplantation, 1994
Abstract: Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies.
Starzl, TE, Murase, N, Tzakis, A, Fung, JJ, Todo, S, Demetris, AJ, Manez, R, Marino, IR, Valdivia, L   +8 more
openaire   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Liver xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT).From 1968 to 2012, survival in pig-to-NHP LXT was limited to 9 days, initially due to
Madhukar S, Patel, Nathan, Louras, Parsia A, Vagefi   +2 more
openaire   +2 more sources

Lung xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
This review describes the most recent progress in xeno lung transplantation (XLTx) to date. It describes the potential mechanisms of early xeno lung graft loss, as well as the latest therapeutic strategies to overcome them.Using ex-vivo perfusion models of porcine lungs with human blood, the use of genetically modified pig lungs along with novel ...
Hisashi, Sahara, Hironosuke, Watanabe, Thomas, Pomposelli, Kazuhiko, Yamada   +3 more
openaire   +2 more sources

Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation

Cells, 2022
Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs.
Tian-Yu Lu, Xue-Ling Xu, Xu-Guang Du, Jin-Hua Wei, Jia-Nan Yu, Shou-Long Deng, Chuan Qin   +6 more
doaj   +1 more source

Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin

Animal Models and Experimental Medicine, 2020
Backgrounds Streptozotocin (STZ)‐ induced diabetic monkey is a wide used preclinical animal model for the investigation of diabetes such as islet transplantation and development of diabetic drugs.
Zhengzhao Liu, Ying Lu, Wenbao Hu, Hidetaka Hara, Yifan Dai, Zhiming Cai, Lisha Mou   +6 more
doaj   +1 more source

Xenotransplantation: Current Status in Preclinical Research

Frontiers in Immunology, 2020
The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between ...
Tianyu Lu, Tianyu Lu, Tianyu Lu, Bochao Yang, Bochao Yang, Bochao Yang, Ruolin Wang, Ruolin Wang, Ruolin Wang, Chuan Qin, Chuan Qin, Chuan Qin   +11 more
doaj   +1 more source