Results 21 to 30 of about 29,864 (273)

Xenotransplantation: A historical–ethical account of viewpoints

Xenotransplantation, 2023
Formal clinical trials of pig‐to‐human organ transplant—known asxenotransplantation—may begin this decade, with the first trials likely to consist of either adult renal transplants or pediatric cardiac transplant patients.
D. Rodger, Daniel J. Hurst, D. Cooper
semanticscholar   +1 more source

Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

Laboratory Animal Research, 2021
Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
doaj   +1 more source

Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

Frontiers in Immunology, 2022
Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao, Heng Zhao, Heng Zhao, Weijian Ye, Weijian Ye, Jianxiong Guo, Jianxiong Guo, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Deling Jiao, Deling Jiao, Deling Jiao, Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Chang Yang, Chang Yang, Shuhan Chen, Shuhan Chen, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Taiyun Wei, Jie Cai, Jie Cai, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Yubo Qing, Yubo Qing, Yubo Qing, Wenmin Cheng, Wenmin Cheng, Wenmin Cheng, Baoyu Jia, Baoyu Jia, Baoyu Jia, Honghui Li, Honghui Li, Honghui Li, Hong-Ye Zhao, Hong-Ye Zhao, Qingfeng Chen, Qingfeng Chen, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +49 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Cell & Bioscience, 2023
Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue   +12 more
doaj   +1 more source

Physiological aspects of pig kidney xenotransplantation and implications for management following transplant

Xenotransplantation, 2022
Successful organ transplantation between species is now possible, using genetic modifications. This article aims to provide a comprehensive overview of the differences and similarities in kidney function between humans, primates, and pigs, in preparation
Christophe Hansen-Estruch, David K. C. Cooper, E. Judd   +2 more
semanticscholar   +1 more source

Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2023
The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs).
Meng Zhou, Manling Zhang, Tianxu Guo, Lihua Zhao, Lihua Zhao, Xiyun Guo, Zhibao Yin, Linxin Cheng, Han Liu, Lixia Zhao, Xihe Li, Rongfeng Li, Rongfeng Li   +12 more
doaj   +1 more source

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?

Xenotransplantation, 2022
The potential for a donor‐derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation.
N. Mueller, J. Denner
semanticscholar   +1 more source

The attitudes of religious group leaders towards xenotransplantation: A focus group study

Xenotransplantation, 2022
Clinical trials of xenotransplantation (XTx) may start in coming years. Religious views have been mentioned as possible barriers to XTx acceptance. While there have been reports on perspectives of theologians in regard to XTx, no report has studied the ...
Daniel J. Hurst, Luz A. Padilla, David K C Cooper, W. Walters, W. Paris   +4 more
semanticscholar   +1 more source

Xenotransplantation: A New Era

Frontiers in Immunology, 2022
Organ allotransplantation has now reached an impassable ceiling inherent to the limited supply of human donor organs. In the United States, there are currently over 100,000 individuals on the national transplant waiting list awaiting a kidney, heart, and/
A. Carrier, A. Verma, M. Mohiuddin, M. Pascual, Y. Muller, A. Longchamp, C. Bhati, L. Buhler, D. Maluf, R. Meier   +9 more
semanticscholar   +1 more source