Results 31 to 40 of about 29,864 (273)

Measuring success in pig to non‐human‐primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life‐sustaining NHP renal allo‐ and xeno‐transplants

American Journal of Transplantation, 2022
Facile gene editing has accelerated progress in pig to non‐human‐primate (NHP) renal xenotransplantation, however, outcomes are considered inferior to NHP‐allotransplantation.
Daniel J Firl, J. Markmann
semanticscholar   +1 more source

Current status of xenotransplantation research and the strategies for preventing xenograft rejection

Frontiers in Immunology, 2022
Transplantation is often the last resort for end-stage organ failures, e.g., kidney, liver, heart, lung, and pancreas. The shortage of donor organs is the main limiting factor for successful transplantation in humans.
Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, S. Deng, Chunming Cheng, Yi Wang   +7 more
semanticscholar   +1 more source

Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Disease Models & Mechanisms, 2018
Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans.
Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai   +19 more
doaj   +1 more source

Cardiac xenotransplantation: from concept to clinic

Cardiovascular Research, 2022
For many patients with terminal/advanced cardiac failure, heart transplantation is the most effective, durable treatment option, and offers the best prospects for a high quality of life.
B. Reichart, D. Cooper, M. Längin, R. Tönjes, R. Pierson, Eckhard Wolf   +5 more
semanticscholar   +1 more source

Virus Safety of Xenotransplantation

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
J. Denner
semanticscholar   +1 more source

The Innate Cellular Immune Response in Xenotransplantation

Frontiers in Immunology, 2022
Xenotransplantation is very attractive strategy for addressing the shortage of donors. While hyper acute rejection (HAR) caused by natural antibodies and complement has been well defined, this is not the case for innate cellular xenogeneic rejection.
A. Maeda, Shuhei Kogata, Chiyoshi Toyama, P. Lo, Chizuko Okamatsu, Riho Yamamoto, Kazunori Masahata, Masafumi Kamiyama, H. Eguchi, M. Watanabe, H. Nagashima, H. Okuyama, S. Miyagawa   +12 more
semanticscholar   +1 more source

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
doaj   +1 more source

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Transplantation Direct, 2020
Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies
Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD   +7 more
doaj   +1 more source

Immunogenetics of xenotransplantation [PDF]

International Journal of Immunogenetics, 2021
AbstractXenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs.
Marco Carvalho‐Oliveira, Emilio Valdivia, Rainer Blasczyk, Constanca Figueiredo   +3 more
openaire   +3 more sources

Xenotransplantation becoming reality

Transgenic research, 2022
To bridge the gap between organ demand and supply, xenotransplantation has long been considered as a realistic option for end-stage organ failure. Early this year this promise became reality for David Bennett Sr., the first patient whose own failing ...
K. Fischer, A. Schnieke
semanticscholar   +1 more source